Eucerin Anti-Pigment Sérum Corporal Para Áreas Sensibles Versus Eucerin Anti Pigment Targeted Areas Body Cream

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

What makes it stand out is how specific it is to human tyrosinase: it was discovered by screening more than 50,000 compounds against recombinant human tyrosinase rather than the mushroom version most older ingredients were tested on.

Thiamidol turned out to be superior to frequently used inhibitors of hyperpigmentation (kojic acid, arbutin, and even hydroquinone) in lab testing.

The clinical evidence is solid as well for a cosmetic ingredient; it matched or beat a 2% hyroquinone for mild-to-moderate melasma in a double-blind study, reduced visible age spots at concentrations as low as 0.1% within 4 weeks, and separate trials show it helps with post-inflammatory hyperpigmentation (the marks left behind after acne).

This ingredient is generally well-tolerated since it doesn't rely on the quinone-forming mechanism that can irritate skin. Studies also report minimal and self-limiting side effects.

Typical usage concentration in finished products is 0.2% (the same amount most of the clinical trials used) and it shows activity as low as 0.1%.

Overall, this is a better-researched brightening active and is a great option if pigmentation is your concern.

Be sure to also check out Rucinol, another "hydroquinone alternative".

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Its main job is chelation; this is a fancy word to say it grabs onto metal ions and neutralizes them. This is because even purified water in cosmetics contains trace amounts of metals that can cause big problems in a formula.

These trace metals can break down actives faster, cause discoloration, promote rancidity in oils, and make preservatives less effective. Trisodium EDTA binds to these metals and takes them out of the equation so your products can stay stable and effective for longer.

There's also an added bonus: by neutralizing the metals ions that bacteria need to thrive, this ingredient also acts as a preservative booster.

The Cosmetic Ingredient Review has concluded this ingredient to be safe as used in cosmetic formulations. It is not considered an irritant, sensitizer, and is barely absorbed through the skin.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!