Mielle Organics Avocado Moisturizing Hair Milk

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Preclinical research has found that topical avocado oil increased collagen synthesis and reduced inflammation during wound healing, giving it some skin-repairing credibility.

The unsaponifiable fraction of the oil is also interesting: studies on avocado unsaponifiables showed that it helped skin produce more collagen and other structural compounds that support healing.

The CIR Expert Panel has found this ingredient to be non-irritating in formulations.

It's a great ingredient for dry or compromised skin. Just know it may not be fungal acne safe. This is because the oleic acid content falls within the range that Malassezia can use as a food source.

Surfactants also help your cleansers remove pollutants more easily from the skin.

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Chemically, it's a blend of esters from 14-18 fatty acids and alcohols that is a solid at room temperature but melts on contact with skin. It helps soften and smooth the skin while improving the feel and spread of products.

Typical use concentrations range from 1-10% (most commonly 2-5%).

The CIR Expert Panel has concluded it's safe as used and has shown no skin irritation in available studies.

Because it's a blend of fatty acid esters in the chain-length range that Malassezia can feed on, it may not be fungal acne safe.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Other antioxidants found in this oil include tocopherols, tocotrienols, and ferulic acid.

According to manufacturers, this oil has a lightweight texture that absorbs nicely.

The CIR (Cosmetic Ingredient Review) has concluded this ingredient to be safe as used in cosmetics and it has not shown to be a skin sensitizer in testing (unless you have a known rice allergy).

Due to the fatty acids (primarily Oleic Acid ~40%, Linoleic Acid ~30%, and some Palmitic Acid), this ingredient may not be fungal acne safe.

In vitro studies have shown that Oleic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.

Unlike other plant oils, jojoba wax doesn't easily penetrate skin. It mostly works in the uppermost layers as an emollient. This just means it forms a light barrier on the skin to help retain moisture.

Formulations with jojoba esters up to 90% reduced transepidermal water loss (TEWL) and increased barrier recovery by 81% (outperforming bisabolol at 47%).

Besides barrier support, the science also suggests jojoba to have anti-inflammatory effects and potential applications for skin infections, aging, and wound healing.

Fun fact: Indigenous cultures have used jojoba as a moisturizer and to help treat burns for centuries.

Fungal acne: The Malassezia yeast is known to metabolize fatty acids in the C11-24 range and jojoba's dominant fatty acid components fall into this range. This ingredient may not be fungal acne safe.

Fun fact: Sage is a member of the mint family.

Another study using a cream with horsetail and soybean extract found 80% of participants showed at least a 26% improvement in forehead wrinkles after 8 weeks.

Animal research has shown topical Equisetum Arvense stimulated skin and tissue growth in mice.

The research so far is encouraging, but still in its early days. But it's a lovely supporting ingredient and can be a welcome addition to any routine.

When exposed to air, these two compounds become strong allergens. This ingredient exhibits cytotoxicity at low concentrations; amounts of 0.25% have been shown to damage skin cells.

The way it works is worth understanding; benzoic acid works when the formula is acidic. It is able to sneak into a microbe's cell and mess up how it functions to stop it from growing in an acidic product.

However, the acid switches to an inactive form and stops working if a product isn't acidic enough (above ~5 pH). This is why you'll often see it in low pH products or teamed up with other preservatives to cover the gap.

Safety wise, it's one of the better studied preservatives out there.

The Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe for use in cosmetic formulations at concentrations up to 5%.

A large international review found this ingredient had no effects on the human body and had low irritation potential.

Just so you know, real world use is usually much lower than the 5% ceiling (usually 1% of less).

The EU caps it at 2.5% in rinse-off products, 1.7% in oral care, and 0.5% in leave-on products.

One thing worth mentioning (it's nothing to worry about): some people get a little stinging or flushing where they apply it. This isn't a true allergy; it's a temporary and harmless reaction. This is the same kind of mild tingle you might notice from sorbic acid.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.