ZO Skin Health Radical Night Repair
A facial treatment with 31 ingredients, including vitamin C, retinoid, and vitamin E.
Overview
What it is
Facial treatment with 31 ingredients that contains retinoid, Vitamin C and Vitamin E
Cool Features
It is cruelty-free and reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, parabens or sulfates
Fun facts
ZO Skin Health is from United States. This product is used in 9 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Cyclopentasiloxane
EmollientDimethicone Crosspolymer
Emulsion StabilisingDimethicone
EmollientPrunus Amygdalus Dulcis Oleosomes
EmollientWater
Skin ConditioningGlycerin
HumectantPolysorbate 20
EmulsifyingRetinol
Skin ConditioningPlukenetia Volubilis Seed Oil
EmollientHelianthus Annuus Seed Oil
EmollientLeontopodium Alpinum Meristem Cell Culture
Skin ConditioningMarrubium Vulgare Meristem Cell Culture
Skin ProtectingZanthoxylum Bungeanum Fruit Extract
Skin ConditioningRosmarinus Officinalis Leaf Extract
AntimicrobialZea Mays Oil
EmulsifyingOleyl Alcohol
EmollientLecithin
EmollientDiisopropyl Adipate
EmollientTocopheryl Acetate
AntioxidantAscorbyl Palmitate
AntioxidantAscorbic Acid
AntioxidantTocopherol
AntioxidantSodium Sulfite
PreservativeBHT
AntioxidantBeta-Carotene
Skin ConditioningCaprylyl Glycol
EmollientParfum
MaskingCitral
PerfumingLimonene
PerfumingPhenoxyethanol
PreservativeChlorphenesin
AntimicrobialCyclopentasiloxane, Dimethicone Crosspolymer, Dimethicone, Prunus Amygdalus Dulcis Oleosomes, Water, Glycerin, Polysorbate 20, Retinol, Plukenetia Volubilis Seed Oil, Helianthus Annuus Seed Oil, Leontopodium Alpinum Meristem Cell Culture, Marrubium Vulgare Meristem Cell Culture, Zanthoxylum Bungeanum Fruit Extract, Rosmarinus Officinalis Leaf Extract, Zea Mays Oil, Oleyl Alcohol, Lecithin, Diisopropyl Adipate, Tocopheryl Acetate, Ascorbyl Palmitate, Ascorbic Acid, Tocopherol, Sodium Sulfite, BHT, Beta-Carotene, Caprylyl Glycol, Parfum, Citral, Limonene, Phenoxyethanol, Chlorphenesin
Key Ingredients
Benefits
Concerns
Ingredients Explained
Cyclopentasiloxane, or D5, is a silicone used to improve texture of products and trap moisture.
D5 is considered lightweight and volatile. Volatile means it evaporates quickly after application. Once evaporated, D5 leaves a thin barrier that helps keep skin hydrated.
It is also an emollient. Emollients help soften the skin and prevent water loss. Silicones create a silky texture in products. D5 helps other ingredients become more spreadable.
Studies show D5 is safe to use in skincare products. We recommend speaking with a skincare professional if you have concerns.
Learn more about CyclopentasiloxaneDimethicone Crosspolymer is a silicone created by modifying dimethicone with hydrocarbon side chains. Due to its large size, it does not penetrate skin. It is considered non-occlusive.
Dimethicone Crosspolymer is used to stabilize and thicken products. It also helps give products a silky feel.
Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeWe don't have a description for Prunus Amygdalus Dulcis Oleosomes yet.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPolysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Learn more about Polysorbate 20Retinol is a gold-standard ingredient for anti-aging. It is a form of Vitamin A and belongs to the class of retinoids that also includes tretinoin.
Why is retinol famous?
It has the most scientific studies backing up its skin benefits out of all the non-prescription ingredients.
Retinol is proven to:
This is why retinol is effective at removing wrinkles, fading dark spots, treating acne, and reducing the appearance of pores.
Studies show retinol is less effective when exposed to UV. Be sure to look for appropriate packaging to keep your retinol potent (similar to Vitamin C).
Using retinol or any retinoids will increase sun-sensitivity in the first few months. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.
We recommend speaking with a medical professional about using this ingredient during pregnancy.
Retinol may cause irritation in some people, so be sure to patch test. Experts recommend 'ramping up' retinol use: start using this ingredient once a week and work up to using it daily.
Read about Tretinoin
Learn more about RetinolPlukenetia Volubilis Seed Oil is an oil and isn't fungal acne safe.
Helianthus Annuus Seed Oil is a plant oil derived from the seeds of a sunflower.
It is rich in fatty acids, primarily linoleic acid and oleic acid. This gives it emollient and skin conditioning properties.
The reason this ingredient is so effective is because it forms a thin film on the skin that reduces transepidermal water loss (TEWL) while supplying linoleic acid to the stratum corneum to improve barrier strength.
The high linoleic acid content is particularly noteworthy for acne-prone skin.
Research suggests that acne-prone skin tends to be deficient in linoleic acid in sebum. Topical application may help replenish this to support a healthier follicular environment and less comedone-promoting sebum.
One randomized study found sunflower seed oil preserved skin barrier integrity in adult volunteers with and without atopic dermatitis (outperforming olive oil).
This ingredient is well-studied, gentle, and an effective emollient suitable for most skin types.
On fungal acne: This ingredient may not be Fungal acne (Malassezia folliculitis) safe. This is because it contains fatty acids with carbon chain lengths in the C11-C24 range.
Learn more about Helianthus Annuus Seed OilWe don't have a description for Leontopodium Alpinum Meristem Cell Culture yet.
We don't have a description for Marrubium Vulgare Meristem Cell Culture yet.
We don't have a description for Zanthoxylum Bungeanum Fruit Extract yet.
Rosmarinus Officinalis Leaf Extract comes from rosemary. Rosemary is native to the Mediterranean.
While Rosmarinus Officinalis Leaf Oil can be volatile due to its fragrant properties, the fragrance components are usually removed in the leaf extract.
Rosemary Leaf Extract contains many antioxidants such as rosmarinic acid and caffeic acid. Rosemarinic acid, a compound found in rosemary leaf, has been found to help soothe skin conditions such as eczema and acne.
Learn more about Rosmarinus Officinalis Leaf ExtractZea Mays Oil is refined oil. It is created from the process of wet milling corn, or zea mays. Zea Mays Oil is fragrance ingredient, hair conditioning agent, occlusive skin conditioning agent, surfactant, and emulsifying agent.
It is composed of several fatty acids, including myristic, palmitic, stearic, oleic, and linoleic.
Oleyl Alcohol is a type of fatty alcohol made from oleic acid.
Fatty Alcohols are most often used as an emollient or to thicken a product. They are usually derived from natural fats and oils and therefore do not have the same drying or irritating effect as solvent alcohols.
Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Depending on the source of this ingredient, lecithin may not be fungal acne safe. This is because some sources of lecithin come from soybean oil, which may feed the malassezia yeast that causes fungal acne.
We recommend reaching out to the brand you are purchasing from to inquire about the source of their lecithin.
Learn more about LecithinDiisopropyl Adipate comes from isopropyl alcohol and Adipic Acid.
It is a solvent and emollient. As a solvent, it is used to help other ingredients dissolve into the solution. It is also often used to soften hard ingredients.
Emollients help hydrate the skin by creating a thin barrier. This thin barrier prevents moisture from escaping.
Learn more about Diisopropyl AdipateTocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.
One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.
Tocopheryl Acetate is commonly found in both skincare and dietary supplements.
Learn more about Tocopheryl AcetateAscorbyl Palmitate is a fat-soluble form of vitamin C (Ascorbic Acid) made by combining it with palmitic acid.
It is able to blend easily into creams and oil-based formulas because it dissolves in oils rather than water.
As you may know, regular vitamin C is notorious for breaking down when exposed to sunlight and air. Ascorbyl Palmitate is more stable and degrades at a slower rate.
Research on whether it converts efficiently into active vitamin C once it's applied on your skin is still limited. Some in-vitro studies suggest it may support collagen production, but it is not considered one of the stronger vitamin C derivatives, like:
Due to the palmitic acid base, this ingredient may not be fungal acne safe. Comedogenic studies have also shown this ingredient to have a rating of 2.
It's also worth keeping in mind that comedogenic and irritancy ratings are tested on individual ingredients, not finished formulas. The final product's formulation, concentration, and other ingredients all play a role in how something actually behaves on your skin.
Learn more about Ascorbyl PalmitateAscorbic Acid is is pure Vitamin C and is the biologically active form used directly by skin.
Not only is vitamin C great for your overall health and immune system, but it also has plenty of benefits for your skin. It is best supported by academic literature for:
Topical vitamin C has been shown to help neutralize oxidative stress from UV and pollution, helping to improve photoaging and hyperpigmentation when used consistently.
One clinical study found that using 5% topical vitamin C for six months improved signs of photodamaged skin, both on the surface and in the deeper structural layers of the skin.
While vitamin C doesnât replace sunscreen, studies show it can boost photoprotection when combined with Vitamin E and ferulic acid. These two ingredients help improve stability and protective effects.
The big downside of this ingredient is formulation difficulty. Vitamin C is prone to oxidation and doesn't penetrate the skin unless formulated correctly. Research found that vitamin C absorbs into the skin best at a low pH (< 3.5) with about 20% being the upper limit for effective absorption.
Skin levels can saturate after repeated application; this means your skin wonât keep absorbing more once itâs full of vitamin C. This is why more isnât always better with vitamin C and why very high concentrations donât necessarily give extra benefits.
Ascorbic acid generally works well with many skincare ingredients but can be irritating when combined with other active ingredients. Strong oxidizing acne treatments like benzoyl peroxide can reduce the effectiveness of vitamin C if they are used at the same time; they are often recommended for use at different times of day.
Read more about other types of Vitamin C:
Foods rich with vitamin C include oranges, strawberries, broccoli, bell peppers, and more. When consuming Vitamin C, your skin receives a portion of the nutrients.
Learn more about Ascorbic AcidTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skinâs lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolSodium Sulfite is a preservative. Preservatives help prevent mold and bacteria from growing in cosmetics.
This ingredient has been shown to break the bonds in hair, acting as a natural straightener.
It is commonly used in food. It should be noted sodium sulfite degrades both vitamins B1 and E.
Fun fact: Sulfites are naturally occuring in wine.
Learn more about Sodium SulfiteBHT is a synthetic antioxidant and preservative.
As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.
As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.
The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.
However, it was recently restricted for use in the UK as of April 2024.
Learn more about BHTBeta-Carotene is a fat-soluble carotenoid pigment. It is the thing responsible for giving carrots, sweet potatoes, apricots, and other orange-yellow produce their color.
It is a potent antioxidant that neutralizes free radicals (mainly reactive oxygen species) that come at your skin from both the environment and internal processes.
When applied topically, beta-carotene accumulates in your outermost layer of skin and acts as a first-line defense against photo-oxidative stress.
Research has established that carotenoids like beta-carotene boosts your skin's innate resistance against UVB induced erythema. Please know this does not mean beta-carotene can replace your sunscreen.
Newer studies show it can also help inhibit molecular markers of oxidative stress like MMP-1 and MMP-9, enzymes that break down collagen.
In some cases, it can be used as a cosmetic colorant as well (INCI name: CI 40800).
Beta-carotene pairs well with other antioxidants like Vitamin E and Vitamin C for a synergistic effect.
Learn more about Beta-CaroteneCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid or alcohol, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of âFRAGRANCEâ or âPARFUMâ according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumCitral is the molecule responsible for the fresh lemon scent in lemon, lime, and lemongrass. It is a fragrance ingredient that can be created from plant essential oils or synthetically.
Though Citral has documented antimicrobial activity against acne bacteria (which is where the marketing claims about it being good for acne-prone skin originate), real formulas use it at fragrance-level concentrations under 1% so there's likely no skin benefit.
You should know this ingredient is a known EU fragrance allergen.
Animal studies classifies this ingredient as a weak-to-moderate skin sensitizer and clinical patch testing on eczema patients confirmed it to be both a contact allergen and irritant.
The term 'citral' is a collective term for two geometric isomers: geranial/Citral A and neral/Citral B.
The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.
Learn more about CitralLimonene is a fragrance that adds scent and taste to a formulation.
It's found in the peel oil of citrus fruits and other plants such as lavender and eucalyptus. The scent of limonene is generally described as "sweet citrus".
Limonene acts as an antioxidant, meaning it helps neutralize free radicals.
When exposed to air, oxidized limonene may sensitize the skin. Because of this, limonene is often avoided by people with sensitive skin.
The term 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term. For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance.
Learn more about LimonenePhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.
Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.
Chlorphenesin is soluble in both water and glycerin.
Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.
Learn more about ChlorphenesinReviews
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Where it's from
ZO Skin Health is a American brand
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The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated June 12, 2025 • Added by junehammers