Versus

Prequel Reactive Skin Solutions 5% Ectoin Cream Versus Paula's Choice Ectoin + Hyaluronic Acid Milky Hydrating Serum - UK

Facial Treatment
Serum
American Brand United States
American Brand United States

Updated on August 11, 2025

Overview

What they are

These products are both cruelty-free and reef safe . They have a total of 3 ingredients in common

Suited For

They're both likely to be good for dry skin, sensitive skin and scar healing

Free From

They both do not contain any harsh alcohols, common allergens, parabens or silicones

What's Inside

They both contain oils

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

What's inside

What's inside

At a glance

Click on any of the items below to learn more

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning

Ectoin is a compound found naturally in some species of bacteria. It can be synthetically created for skincare use.

This ingredient is an osmolyte; Osmolytes help organisms survive osmotic shock (it protects them from extreme conditions). It does this by influencing the properties of biological fluids within cells.

When applied to the skin, ectoin helps bind water molecules to protect our skin. The water forms a sort of armor for the parts of our skin cells, enzymes, proteins, and more.

Besides this, ectoin has many uses in skincare:

A study from 2004 found ectoin to counteract the damage from UV-A exposure at different cell levels. It has also been shown to protect skin against both UV-A, UV-B rays, infrared light, and visible light.

Studies show ectoin to have dual-action pollution protection: first, it protects our skin from further pollution damage. Second, it helps repair damage from pollution.

In fact, ectoin has been shown to help with:

Fun fact: In the EU, ectoin is used in inhalation medication as an anti-pollution ingredient.

Ectoin is a highly stable ingredient. It has a wide pH range of 1-9. Light, oxygen, and temperature do not affect this ingredient.

Learn more about Ectoin
Emollient, Skin Conditioning

This oil comes from the seeds of the desert shrub called Jojoba. It is more commonly known as jojoba oil, a non-comedogenic oil.

Jojoba oil does not contain fragrance and has many fatty-acids, making it a great soothing ingredient.

It also contains Vitamin E, a great moisturizing ingredient. Vitamin E is also an antioxidant and protects your skin against oxidative damage.

This ingredient humectant properties, meaning it helps draw moisture from the air. This helps keep your skin hydrated.

While jojoba has antibacterial properties, it is only able to kill some strains of bacteria.

Studies also show it helps in wound healing. In fact, Indigenous cultures have used jojoba as a moisturizer and to help treat burns for centuries.

Fun fact: Jojoba oil similar to natural human skin sebum, so it has a great effect on dry skin. It is also promising with helping to regulate sebum production.

Due to its fatty acid content, Jojoba oil may not be fungal acne safe. We recommend speaking with a professional if you have any concerns.

Learn more about Simmondsia Chinensis Seed Oil
Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

When to use

31 Routines
39% use in am
61% use in pm
90% use every day
When to use See routines that use it ->
3 Routines
67% use in am
33% use in pm
100% use every day