Coco & Eve Bronzing Face Drops Versus Isle of Paradise Self Tan Drops

DHA does not penetrate living skin cells, does not interact with melanocytes, and does not affect actualy melanin production.

There's a "safety controversy" that largely stems from misinterpreted studies:

Once concern is that DHA can generate unstable molecules that can damage cells (free radicals) when exposed to sunlight. This only happens in the outermost layer of dead skin cells and wearing SPF on top takes care of it.

The DNA damage claim comes from lab studies that doused living skin cells in much higher concentrations of DHA than you'd ever find in a self-tanner. That's not really a meaningful comparison to putting self-tanning lotion on your skin.

Regulatory bodies around the world, including the EU's Scientific Committee on Consumer Safety (SCCS) and the U.S. FDA consider it safe for use in cosmetics when applied topically (maximum 10%, and most self-tanners contain between 3-5%).

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

This is why the best HA serums blend the two sizes together so you get the best of both worlds.

The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.

A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.

These are some other common types of Hyaluronic Acid: