La Roche-Posay Redermic R Eyes Anti-Aging Eye Cream with Retinol Versus Vichy Liftactiv Supreme Eye Cream
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningIsocetyl Stearate
EmollientGlycerin
HumectantOctyldodecanol
EmollientPropylene Glycol
HumectantPentylene Glycol
Skin ConditioningDimethicone
EmollientAcrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion StabilisingCetearyl Alcohol
EmollientDimethicone/Vinyl Dimethicone Crosspolymer
Skin ConditioningCaffeine
Skin ConditioningIsohexadecane
EmollientSodium Hyaluronate
HumectantSodium Hydroxide
BufferingRetinol
Skin ConditioningRetinyl Linoleate
Skin ConditioningAdenosine
Skin ConditioningAmmonium Polyacryloyldimethyl Taurate
Emulsion StabilisingCaprylyl Glycol
EmollientCitric Acid
BufferingPolysilicone-8
Polysorbate 80
EmulsifyingPhenoxyethanol
PreservativeWater, Isocetyl Stearate, Glycerin, Octyldodecanol, Propylene Glycol, Pentylene Glycol, Dimethicone, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Cetearyl Alcohol, Dimethicone/Vinyl Dimethicone Crosspolymer, Caffeine, Isohexadecane, Sodium Hyaluronate, Sodium Hydroxide, Retinol, Retinyl Linoleate, Adenosine, Ammonium Polyacryloyldimethyl Taurate, Caprylyl Glycol, Citric Acid, Polysilicone-8, Polysorbate 80, Phenoxyethanol
Water
Skin ConditioningDimethicone
EmollientHydrogenated Polyisobutene
EmollientGlycerin
HumectantRhamnose
HumectantCetyl Alcohol
EmollientGlyceryl Stearate
EmollientPolymethyl Methacrylate
PEG-40 Stearate
EmulsifyingCera Alba
EmollientPentylene Glycol
Skin ConditioningStearic Acid
CleansingStearyl Alcohol
EmollientSorbitan Tristearate
EmulsifyingTriethanolamine
BufferingCaffeine
Skin ConditioningSodium Dextran Sulfate
Gel FormingMyristyl Alcohol
EmollientEscin
TonicPalmitic Acid
EmollientPhenoxyethanol
PreservativeAdenosine
Skin ConditioningMagnesium Ascorbyl Phosphate
AntioxidantTocopheryl Acetate
AntioxidantPoloxamer 338
EmulsifyingAscorbyl Glucoside
AntioxidantCaprylyl Glycol
EmollientWater, Dimethicone, Hydrogenated Polyisobutene, Glycerin, Rhamnose, Cetyl Alcohol, Glyceryl Stearate, Polymethyl Methacrylate, PEG-40 Stearate, Cera Alba, Pentylene Glycol, Stearic Acid, Stearyl Alcohol, Sorbitan Tristearate, Triethanolamine, Caffeine, Sodium Dextran Sulfate, Myristyl Alcohol, Escin, Palmitic Acid, Phenoxyethanol, Adenosine, Magnesium Ascorbyl Phosphate, Tocopheryl Acetate, Poloxamer 338, Ascorbyl Glucoside, Caprylyl Glycol
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.
The way it works is fairly well mapped out:
Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.
The clinical backing is pretty solid too.
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.
A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.
On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.
This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.
Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.
Learn more about AdenosineCaffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
Learn more about CaffeineCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Learn more about Pentylene GlycolPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water