Updated on July 18, 2023
Overview
What they are
These products are both reef safe serums. They have a total of 7 ingredients in common
Cool Features
They both contain Vitamin E
Suited For
They're both likely to be good for dry skin and brightening skin
Free From
They both do not contain any common allergens, oils or parabens
What's Inside
They both contain harsh alcohols and fragrances
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
La Roche-Posay Hyalu B5 Face Serum with Hyaluronic Acid 22 ingredients
Is Clinical Pro-Heal Serum Advance 17 ingredients
At a glance
Click on any of the items below to learn more
La Roche-Posay Hyalu B5 Face Serum with Hyaluronic Acid 22 ingredients
Is Clinical Pro-Heal Serum Advance 17 ingredients
Notable Ingredients
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Benefits
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Concerns
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Notable Ingredients
This product contains 1 ingredient that may have this attribute:
This product contains 1 ingredient that may have this attribute:
This product contains 1 ingredient that may have this attribute:
Benefits
This product contains 2 ingredients that may have this attribute:
This product contains 1 ingredient that may have this attribute:
This product contains 1 ingredient that may have this attribute:
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Concerns
This product contains 2 ingredients that may have this attribute:
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Ingredients Side-by-side
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
5 Concerns
Alcohol Denat. is an alcohol with a denaturant property. It is created by mixing ethanol with other additives.
Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.
Panthenol is a common ingredient that helps hydrate and soothe the skin. It can be found naturally in our skin and hair.
Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
Dimethicone is a silicone used for making products smooth and silky. It also has the added benefit of sealing in hydration. The amount of dimethicone found in beauty products is considered safe and non-comedogenic, meaning it won't clog pores.
This ingredient is derived from caprylic and capric acids. It is an emulsifier with emollient properties.
Glyceryl Isostearate is a mixture made from glycerin and isostearic acid.
Helps reduce irritation
Madecassoside comes from the super popular skin-soothing ingredient, Centella asiatica. It is one of four active compounds found in the extract of Centella Asiatica.
Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Ammonium Polyacryloyldimethyl Taurate is a polymer made from ammonium salts. It helps add stability and texture to a product.
Disodium EDTA plays a role in making products more stable by aiding other preservatives.
Hydrolyzed Hyaluronic Acid is a form of hyaluronic acid. It is created by the hydrolysis of hyaluronic acid with a high molecular weight. Once created, Hydrolyzed Hyaluronic Acid has a low molecular weight.
Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.
4 Benefits 2 Concerns
Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Antioxidant 4 Benefits May cause irritation
Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
2 Concerns
Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Water, Glycerin, Alcohol Denat., Propylene Glycol, Panthenol, Pentylene Glycol, Dimethicone, Peg-6 Caprylic/Capric Glycerides, Ppg-6-Decyltetradeceth-30, Glyceryl Isostearate, Madecassoside, Sodium Hyaluronate, Ammonium Polyacryloyldimethyl Taurate, Disodium EDTA, Hydrolyzed Hyaluronic Acid, Caprylyl Glycol, Citric Acid, Xanthan Gum, Butylene Glycol, Tocopherol, Phenoxyethanol, Parfum
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
Antioxidant 6 Benefits
Ascorbic Acid is is pure Vitamin C. This form makes up the largest amount of vitamin C found naturally in our skin.
Laureth-4 is created by reacting ethylene oxide with Lauryl Alcohol. It is a surfactant and emulsifier.
5 Concerns
Alcohol Denat. is an alcohol with a denaturant property. It is created by mixing ethanol with other additives.
Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.
Triethanolamine is an emulsifier and pH adjuster. It is created using ethylene oxide and ammonia. This gives Triethanolamine a nitrogen core and a similar scent to ammonia.
Antioxidant 4 Benefits May cause irritation
Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.
Bioflavonoids are secondary metabolites found in plants. They contain antioxidants.
8 Benefits 3 Concerns
Retinol is a gold-standard ingredient for anti-aging. It is a form of Vitamin A and belongs to the class of retinoids that also includes tretinoin.
2 Benefits
Arbutin is derived from the bearberry plant. It helps even out skin tone and reduce hyperpigmentation.
Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinAlcohol Denat. is an alcohol with a denaturant property. It is created by mixing ethanol with other additives.
This ingredient gets a bad rep because it is irritating and drying - mostly due to its astringent property. Astringents draw out natural oils in tissue, constricting pores and leaving your skin dried out.
However, alcohol denat. is not all that bad.
Due to its low molecular weight, alcohol denat. tends to evaporate quickly. One study on pig skin found half of applied alcohol evaporated in 10 seconds and less than 3% stayed on skin.
This also helps other ingredients become better absorbed upon application.
Studies are conflicted about whether this ingredient causes skin dehydration. One study from 2005 found adding emollients to propanol-based sanitizer decreased skin dryness and irritation. Another study found irritation only occurs if your skin is already damaged.
Small amounts of alcohol are generally tolerated by oily skin or people who live in humid environments.
The rule of thumb is if this alcohol is near the end of an ingredients list, it will probably not affect your skin much.
Also...
This ingredient has antimicrobial and solvent properties.
The antimicrobial property helps preserve products and increase their shelf life. As a solvent, it helps dissolve other ingredients.
Other types of astringent alcohols include:
Learn more about Alcohol Denat.Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.
Another role of this ingredient is preventing a product from melting or freezing. Propylene glycol also adds antimicrobrial properties to a product, elongating product lifespan.
This ingredient is considered an organic alcohol and commonly added into both cosmetics and foods.
Those with sensitive skin or conditions may deliver a rash when using this ingredient.
Learn more about Propylene GlycolPentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.
This property also makes Pentylene Glycol a great texture enhancer. It can help thicken or emulsify a product. Emulsifiers help stabilize a product. It does this by preventing certain ingredients from separating.
Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.
Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.
Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.
Learn more about Pentylene GlycolTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Ingredient Ratings
Here's what our community thinks of the ingredients in these two products.
When to use
La Roche-Posay Hyalu B5 Face Serum with Hyaluronic Acid 22 ingredients
Is Clinical Pro-Heal Serum Advance 17 ingredients
Reviews
Here's what our community thinks
La Roche-Posay Hyalu B5 Face Serum with Hyaluronic Acid 22 ingredients
sophia d
Have yet to find a serum that compares. So so so hydrating and amazing. It’s my holy grail and I’ve been using it for nearly 5 years. Amazing AM...
Have yet to find a serum that compares. So so so hydrating and amazing. It’s my holy grail and I’ve been using it for nearly 5 years. Amazing AM and PM hydration boost.
GabriellaTsoukalas
LOVED IT
My dermatologist recommended me this product after finishing my acne treatment pills. I LOOOVEEEED IT. I bought the effaclar serum so I...
LOVED IT
My dermatologist recommended me this product after finishing my acne treatment pills. I LOOOVEEEED IT. I bought the effaclar serum so I stopped using it. (I was so into La roche posay!!). I would repurchased it again and use it on my night routine (still trying to figure out what to use). It's a bit expensive for me hihi.
