Versus

Dear, Klairs Midnight Blue Youth Activating Drop Versus Isntree TW-Real Bifida Ampoule

Serum
Ampoule
Korean Brand South Korea
Korean Brand South Korea

Updated on September 05, 2024

Overview

What they are

These products are both cruelty-free and reef safe . They have a total of 10 ingredients in common

Cool Features

They both contain peptides

Suited For

They're both likely to be good for anti aging, dry skin, brightening skin, sensitive skin, reducing pores and scar healing

Free From

They both do not contain any harsh alcohols, common allergens, parabens or sulfates

What's Inside

They both contain fragrances and oils

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

What's inside (and what isn't)

What's inside (and what isn't)

At a glance

Click on any of the items below to learn more

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
TW-Real Bifida Ampoule

Water

Skin Conditioning

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Dipropylene Glycol

Masking

Glycerin

Humectant
0 / 0 Helps hydrate Dry Skin IconGood for Scar Healing IconHelps brighten skin Icon

Cyclopentasiloxane

Emollient
Silicon Icon

Squalane

Emollient
1 / 0 Helps hydrate Dry Skin Icon

Hydrogenated Polydecene

Emollient

Niacinamide

Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Dark Spots IconGood for Scar Healing IconHelps fight Acne IconHelps brighten skin Icon

Dimethicone

Emollient
1 / 0 Silicon Icon

Pentaerythrityl Tetraethylhexanoate

Emollient
Helps hydrate Dry Skin Icon

Bifida Ferment Lysate

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation Icon

Arachidyl Alcohol

Emollient

Butyrospermum Parkii Butter

Skin Conditioning
Helps hydrate Dry Skin IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Cetearyl Alcohol

Emollient
2 / 1 Fatty Alcohol IconMay worsen Oily Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

C12-16 Alcohols

Emollient

Polyglyceryl-2 Stearate

Emulsifying
Not safe for Fungal Acne Icon

Dimethicone/Vinyl Dimethicone Crosspolymer

Skin Conditioning

Behenyl Alcohol

Emollient
Fatty Alcohol Icon

Erythritol

Humectant
Helps hydrate Dry Skin Icon

Polysorbate 60

Emulsifying
Not safe for Fungal Acne Icon

1,2-Hexanediol

Skin Conditioning
Helps hydrate Dry Skin Icon

Glyceryl Stearate

Emollient
1 / 0 Not safe for Fungal Acne Icon

Hydrogenated Lecithin

Emulsifying
Helps hydrate Dry Skin Icon

Stearyl Alcohol

Emollient
2 / 2 Fatty Alcohol Icon

Arachidyl Glucoside

Emulsifying

Palmitic Acid

Emollient
2 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon

Allantoin

Skin Conditioning
0 / 0 Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon

Carbomer

Emulsion Stabilising
1 / 0

Tromethamine

Buffering

Illicium Verum Fruit Extract

Perfuming
Fragrance Icon

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Mangifera Indica Seed Butter

Skin Conditioning
Not safe for Fungal Acne Icon

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Emulsion Stabilising

Isohexadecane

Emollient

Persea Gratissima Oil

Skin Conditioning
0-3 / 0 Oil IconHelps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Hydroxyethylcellulose

Emulsion Stabilising

Scutellaria Baicalensis Root Extract

Astringent

Adenosine

Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce irritation IconGood for Minimizing Pores IconHelps with Anti-Aging IconGood for Scar Healing Icon

Polysorbate 80

Emulsifying
0 / 0 May worsen Oily Skin IconNot safe for Fungal Acne Icon

Disodium EDTA

Hydrogenated Vegetable Oil

Emollient
3 / 0 Oil IconHelps hydrate Dry Skin IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Ceramide NP

Skin Conditioning
Ceramide IconHelps hydrate Dry Skin IconHelps reduce irritation IconHelps with Anti-Aging Icon

3-O-Ethyl Ascorbic Acid

Skin Conditioning
Vitamin C IconHelps reduce Skin Redness IconGood for Skin Texture IconGood for Minimizing Pores Icon

Sorbitan Oleate

Emulsifying
3 / 0 Bad for Acne Prone Skin IconNot safe for Fungal Acne Icon

Glucose

Humectant
Helps hydrate Dry Skin Icon

Caprylic/Capric Triglyceride

Masking
Helps hydrate Dry Skin Icon

Daucus Carota Sativa Root Extract

Skin Conditioning
Helps reduce irritation Icon

Caprylyl Glycol

Emollient

Sodium Phosphate

Buffering

Pentylene Glycol

Skin Conditioning

Deoxyphytantriyl Palmitamide Mea

Skin Conditioning

Tocopherol

Antioxidant
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing Icon

Ethylhexylglycerin

Skin Conditioning

Polysorbate 20

Emulsifying
0 / 0 Not safe for Fungal Acne Icon

Cholesterol

Emollient
0 / 0 Helps hydrate Dry Skin Icon

Lecithin

Emollient
Helps hydrate Dry Skin Icon

Phosphatidylcholine

Emulsifying

Acetyl Hexapeptide-8

Humectant
Peptide IconHelps hydrate Dry Skin IconHelps with Anti-Aging Icon

Sh-Oligopeptide-2

Skin Conditioning
Peptide Icon

Sh-Polypeptide-1

Skin Conditioning
Peptide Icon

Astaxanthin

Skin Conditioning
Helps reduce irritation IconHelps with Anti-Aging Icon

Sh-Oligopeptide-1

Skin Conditioning
Peptide IconHelps with Anti-Aging IconGood for Scar Healing Icon

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Skin Conditioning

sh-Oligopeptide-1 is a peptide found naturally in our bodies. Peptides are the building blocks for collagen and elastin in our skin.

In cosmetics, this ingredient is bioengineered to be identical to a human gene that codes for epidermal growth factor (EGF). EGF are signal molecules that simulate cell growth and healing.

Studies find EGF help with:

In South Korea and China, EGF is considered a controversial ingredient. The South Korean Ministry of Food and Drug Safety has cracked down on companies with products including EGF due to false advertisement claims.

According to Dr. Zoe Draelos, growth factors have some drawbacks:

There is also controversy surrounding growth factors. The controversy is due to their mitogenic activity, or their ability to increase the number of cells. It is best to avoid using growth factors if you have psoriasis or are at risk of skin cancer. However, it should be noted EGF are not mutagenic - meaning they will not cause cancer.

Learn more about Sh-Oligopeptide-1
Skin Conditioning

Sh-Polypeptide-1 is a signal peptide that tells our cells to create more fibroblast cells. Fibroblasts maintain skin structure and plays a role in wound healing.

It is important to note this ingredient is mitogenic and not mutagenic. Meaning it will stimulate cell multiplication, and will not cause cancer.

Emollient, Emulsifying, Skin Conditioning

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of mixture of phospholipids.

This ingredient has emollient and emulsifying properties.

As an emollient, lecithen helps soften the skin and creates a barrier to keep moisture in.

As an emulsifier, it also helps prevent water and oil ingredients from separating. Lecithin can also help ingredients be better absorbed by the skin.

This is because the phospholipids in lecithin produce liposomes. Liposomes help other ingredients get through the skin barrier.

Depending on the source of this ingredient, lecithin may not be fungal acne safe. This is because some sources of lecithin come from soybean oil, which may feed the malassezia yeast that feeds fungal acne.

We recommend reaching out to the brand you are purchasing from to inquire about the source of their lecithin.

Learn more about Lecithin
Skin Conditioning, Solvent

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse. 

It is a:

  • Humectant, drawing moisture into the skin
  • Emollient, helping to soften skin
  • Solvent, dispersing and stabilizing formulas
  • Preservative booster, enhancing the antimicrobial activity of other preservatives 
Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Skin Conditioning

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Learn more about Adenosine

When to use

87 Routines
28% use in am
72% use in pm
87% use every day
When to use See routines that use it ->
22 Routines
41% use in am
59% use in pm
82% use every day

Reviews

Here's what our community thinks

Dear, Klairs Midnight Blue Youth Activating Drop 15 ingredients

3.7 /5
from 3 ratings
Works Well (2) Great Value (2) Light (2)
linnakjellman's avatar

Linkje

7 months ago
Review

It wasn’t bad but it wasn’t good either, I didn’t really notice a difference at all when using it. I used up the whole bottle but still no noticeable difference at all. So I decided that it wasn’t worth buying another one and that there are more peptide options out there, especially more affordable ones.

#expensive
#doesn't work
EveliV's avatar

EveliV

1 year ago
Review

A little miracle worker! I don't know what makes this so nice, but its not irritating and has helped with blemish control. Very light and with no strong scent, it absorbs fast and gives my tired skin a little boost.

#great value
#light
#absorbs well
#light scent

Isntree TW-Real Bifida Ampoule 62 ingredients

2.7 /5
from 3 ratings
Absorbs Well (2) Broke Me Out (1) Doesn't Work (1)
nikisadaghiani's avatar

Niki Sdni

7 months ago
Review

I haven’t used a full bottle only tried for few days, still didn’t like it that much, what does it suppose to do? Not a bad product, but many many better alternatives are available

#expensive
#hydrating
#absorbs well
#no scent
Suzamazen's avatar

Suzanne S.

2 months ago
Review

I absolutely loved the original version of this serum. It helped my oily, cystic-acne prone skin retain moisture and let my skin handle harsher products like acid exfoliants and benzoyl peroxide without completely stripping my skin. This new formulation is a list of the worst ingredients for oily and acne prone skin. Using the SkinSort match score, the original formulation was a 88% match for Show more

#broke me out