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ma:nyo Bifida Complex Ampoule Versus Numbuzin No.3 Skin Softening Serum

Ampoule
Serum
Korean Brand South Korea
Korean Brand South Korea

Updated on August 20, 2024

Overview

What they are

These products are both cruelty-free and reef safe . They have a total of 7 ingredients in common

Cool Features

They both contain hyaluronic acid and niacinamide

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, oily skin, reducing pores and dark spots

Free From

They both do not contain any harsh alcohols, common allergens, fragrances, oils, parabens, silicones or sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

Free from

Safety & Ethics

Korean Brand

Brand country of origin

Free from

Safety & Ethics

Korean Brand

Brand country of origin

At a glance

Click on any of the items below to learn more

Ingredients, at a glance

What's in this product, and how it might affect your skin.

Notable Ingredients

Benefits

Ingredients, at a glance

What's in this product, and how it might affect your skin.

Notable Ingredients

Benefits

Ingredients Side-by-side

found in both products
Bifida Complex Ampoule
Bifida Ferment Lysate Skin Conditioning
Helps hydrate Dry Skin Icon

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

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Helps hydrate Dry SkinHelps hydrate Dry Skin Icon
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Lactobacillus/Pumpkin Fruit Ferment Filtrate Skin Conditioning

We don't have a description for Lactobacillus/Pumpkin Fruit Ferment Filtrate yet.

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Niacinamide Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconGood for Minimizing Pores IconGood for Dark Spots IconHelps fight Acne IconHelps brighten skin Icon

Niacinamide has emerged as an all-star ingredient due to its many benefits.

Loved by users
NiacinamideNiacinamide Icon6 Benefits
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Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Mixed reviews
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Acetyl Hexapeptide-8 Humectant, Skin Conditioning
Peptide Icon

Acetyl Hexapeptide-8 is a peptide. A common name for this peptide is Argireline.

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PeptidePeptide Icon
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Aureobasidium Pullulans Ferment Skin Conditioning

We don't have a description for Aureobasidium Pullulans Ferment yet.

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Hydrolyzed Algin

We don't have a description for Hydrolyzed Algin yet.

Mixed reviews
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Caffeine Skin Conditioning

Caffeine is most associated with coffee, tea, and cacao. In skincare, it helps with calming inflammation and anti-aging.

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Panax Ginseng Root Extract Emollient, Skin Protecting, Tonic
Helps hydrate Dry Skin IconHelps reduce Skin Redness Icon

Panax Ginseng Root is a popular herb from Asia. This root contains antioxidants, favonoids, and vitamins B12 and D.

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2 Benefits
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Panax Ginseng Callus Culture Extract Skin Conditioning

This ingredient comes from the callus cells of ginseng.

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Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Loved by users
2 Benefits
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Epigallocatechin Gallate Antioxidant
Antioxidant Icon

EGCG is most famous for being found in green tea. It is a type of catechin, a potent antioxidant.

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AntioxidantAntioxidant Icon
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Zanthoxylum Piperitum Fruit Extract Skin Conditioning

Zanthoxylum Piperitum Fruit Extract comes from the Japanese Pepper, also known as the Prickly Ash. This plant is native to the Korean peninsula and Japan.

Mixed reviews
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Pulsatilla Koreana Extract Skin Conditioning

Pulsatilla Koreana Extract comes from the Korean pasque flower. This flower is used in traditional Korean medicine.

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Usnea Barbata Extract

We don't have a description for Usnea Barbata Extract yet.

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Copper Tripeptide-1 Skin Conditioning
Peptide IconHelps with Anti-Aging Icon

Copper Tripeptide-1 is a peptide naturally found in body fluids. Peptides are building blocks for protein.

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PeptidePeptide IconHelps with Anti-AgingHelps with Anti-Aging Icon
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Physalis Alkekengi Fruit Extract Skin Conditioning

We don't have a description for Physalis Alkekengi Fruit Extract yet.

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Methyl Gluceth-20 Humectant, Moisturising

Methyl Gluceth-20 is a humectant. Humectants help draw moisture from the air to your skin.

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Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
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Hyaluronic AcidHyaluronic Acid Icon
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Adenosine Skin Conditioning
Helps with Anti-Aging IconGood for Scar Healing Icon

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

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2 Benefits
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No.3 Skin Softening Serum
Bifida Ferment Lysate Skin Conditioning
Helps hydrate Dry Skin Icon

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Liked by users
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon
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Galactomyces Ferment Filtrate Humectant
Helps hydrate Dry Skin IconNot safe for Fungal Acne Icon

Galactomyces Ferment Filtrate (GFF) is a yeast traditionally used to make the Japanese alcoholic beverage, sake.

Mixed reviews
Helps hydrate Dry SkinHelps hydrate Dry Skin IconNot safe for Fungal AcneNot safe for Fungal Acne Icon
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Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Mixed reviews
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Methyl Gluceth-20 Humectant, Moisturising

Methyl Gluceth-20 is a humectant. Humectants help draw moisture from the air to your skin.

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Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

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Niacinamide Smoothing
Niacinamide IconGood for Oily Skin IconHelps reduce Skin Redness IconGood for Minimizing Pores IconGood for Dark Spots IconHelps fight Acne IconHelps brighten skin Icon

Niacinamide has emerged as an all-star ingredient due to its many benefits.

Loved by users
NiacinamideNiacinamide Icon6 Benefits
Learn more
Peg-90 Humectant, Solvent
Not safe for Fungal Acne Icon

Peg-90 isn't fungal acne safe.

Very disliked
Not safe for Fungal AcneNot safe for Fungal Acne Icon
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1,2-Hexanediol Skin Conditioning, Solvent

1,2-Hexanediol is a multi-tasker ingredient. It acts as a preservative to increase shelf-life and can aid other preservatives in preventing microbe growth. 1,2-Hexanediol also helps the skin retain moisture as a humectant.

Mixed reviews
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Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Loved by users
2 Benefits
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Squalane Emollient, Skin Conditioning
1 / 0 Helps hydrate Dry Skin Icon

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

1 Com. / 0 Irr.
Loved by users
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon
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Alteromonas Ferment Extract Skin Conditioning

Alteromonas Ferment Extract is derived from a bacteria from in deep sea water.

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Silk Extract Skin Conditioning

We don't have a description for Silk Extract yet.

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Goat Milk Extract

We don't have a description for Goat Milk Extract yet.

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Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0 Hyaluronic Acid Icon

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
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Hyaluronic AcidHyaluronic Acid Icon
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Panthenol Skin Conditioning
0 / 0 Helps reduce irritation Icon

Panthenol is a common ingredient that helps hydrate and soothe the skin. It can be found naturally in our skin and hair.

0 Com. / 0 Irr.
Loved by users
Helps reduce irritationHelps reduce irritation Icon
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Adenosine Skin Conditioning
Helps with Anti-Aging IconGood for Scar Healing Icon

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

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2 Benefits
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Glycereth-26 Humectant
0 / 0

Glycereth-26 is a synthetic ingredient and polyethylene glycol ether of Glycerin. Glycerin is already naturally found in your skin and helps keep your skin moisturized.

0 Com. / 0 Irr.
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Xanthan Gum Emulsifying, Emulsion Stabilising, Gel Forming

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

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Polyglyceryl-3 Distearate Emulsifying
Not safe for Fungal Acne Icon

Polyglyceryl-3 Distearate isn't fungal acne safe.

Very disliked
Not safe for Fungal AcneNot safe for Fungal Acne Icon
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Glyceryl Stearate Se Emulsifying
3 / 2 Not safe for Fungal Acne Icon

Glyceryl Stearate Se is a self-emulsifying (SE) form of glyceryl stearate. Self-emusifying means this ingredient automatically blends with water. It is an emulsifier, emollient, and cleansing agent.

3 Com. / 2 Irr.
Very disliked
Not safe for Fungal AcneNot safe for Fungal Acne Icon
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Glyceryl Stearate Citrate Emollient, Emulsifying, Skin Conditioning
Not safe for Fungal Acne Icon

Glyceryl Stearate Citrate is a citric acid ester of glyceryl stearate.

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Not safe for Fungal AcneNot safe for Fungal Acne Icon
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Polyglyceryl-3 Methylglucose Distearate Emulsifying
Not safe for Fungal Acne Icon

Polyglyceryl-3 Methylglucose Distearate is created from the diester of stearic acid and the condensation product of methylglucose and Polyglycerin-3.

Very disliked
Not safe for Fungal AcneNot safe for Fungal Acne Icon
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Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
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Tromethamine Buffering, Masking

Tromethamine is an aliphatic compound. An aliphatic compound is an organic compound with open-chained carbon atoms. It is synthetically created. Tromethamine is used to balance pH and improve texture.

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Ethylhexylglycerin Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

Mixed reviews
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Caprylyl Glycol Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

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Tropolone Skin Conditioning

We don't have a description for Tropolone yet.

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Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

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Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning
Liked

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Having a healthy microbiome helps protect our skin against infection. It also helps our skin stay hydrated and healthy.

Studies also show this ingredient to be a promising soothing ingredient for sensitive skin.

Learn more about Bifida Ferment Lysate
Smoothing
Loved

Niacinamide has emerged as an all-star ingredient due to its many benefits.

It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.

Other benefits include smoothing wrinkles and minimizing redness.

The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.

Learn more about Niacinamide
Humectant, Masking, Skin Conditioning
Mixed

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Humectant, Skin Conditioning, Skin Protecting
Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Humectant, Moisturising
Liked

Methyl Gluceth-20 is a humectant. Humectants help draw moisture from the air to your skin.

It is created by combining polyethylene glycol with glucose.

Humectant, Skin Conditioning
Loved

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Skin Conditioning
Loved

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Learn more about Adenosine

When to use

152 Routines
41% use in am
59% use in pm
92% use every day
When to use See routines that use it ->
1,541 Routines
42% use in am
58% use in pm
92% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

ma:nyo Bifida Complex Ampoule 20 ingredients

4.0 /5
from 4 ratings
No Scent (4) Works Well (3) Hydrating (3)
nja's avatar

nja

9 months ago · Sensitive Skin
Review

This is some pretty amazing stuff, it's what makes my skin glow! Bifida is great for the skin barrier and pumpkin fruit ferment filtrate has...

This is some pretty amazing stuff, it's what makes my skin glow! Bifida is great for the skin barrier and pumpkin fruit ferment filtrate has exfoliation properties. It also has peptides and niacinamide. Basically te entire INCI is amazing and it's also FA safe. The other version - Bifida BIOME Complex Ampoule - is *not* FA safe but it's very easy to get them mixed up because they look identical.
This ampoule exfoliates the skin and quite effectively, at least in my experience! So if you have very sensitive skin or are using any actives, keep that in mind. My skin gets a little flushed with this but I am using tretinoin. For now I use it once a week but when my skin gets totally used to tret, I plan on using it more because I love it!! It is kind of oily on the skin but it doesn't bother me when it works so well. The glow it gives is unmached!!

Flora_Maeve02's avatar

Flora_Maeve02

4 months ago · Combination Skin
Review

So I have oily, sensitive, and acne prone skin and let me just say—this serum is absolutely incredible! My skin is so finicky about products and...

So I have oily, sensitive, and acne prone skin and let me just say—this serum is absolutely incredible! My skin is so finicky about products and ingredients that normally work wonders for others. So, when I heard the positive reviews from others about this product I was prepared for it to be yet another flop…But THIS serum omg! It’s outstanding. I notice my skin is less red after using this, my pimples decrease, AND I swear it helps sooth and lessen my hormonal acne. 10/10 highly recommend!

Numbuzin No.3 Skin Softening Serum 28 ingredients

3.9 /5
from 29 ratings
Works Well (9) Absorbs Well (7) Light (7)
cgi's avatar

cgi

10 months ago · Oily Skin
Review

numbuzin has become one of my favorite brands along with cosrx. this is one of the two serums i own from them, this and the no.5 goodbye blemish...

numbuzin has become one of my favorite brands along with cosrx. this is one of the two serums i own from them, this and the no.5 goodbye blemish serum.
i've only been using this since march of last year and it has been a game-changer ever since. i feel a bit dramatic when i say this, but i genuinely have seen a big difference in my skin using this compared to any other serum i've ever used. it blended in with my routine sooo unbelievably well. i don't know what type of witchcraft or sorcery is in this, but this product is a blessing and it's money VERY well-spent. beautiful bottle, it's like glass or something. it's a bit expensive, but you get so much product that'll last you way longer than a year. like i've had this since MARCH, and i still have over half the bottle left even though i use 3 drops every single night religiously.
it's hydrating, makes my skin very smooth (as it should), and has gone above and beyond in improving my skin texture. it miraculously decreased so many of the little bumps i get. it also absorbs very well under my base, literally just cleared my skin and boosted the glass skin look. i love this serum please buy it.

anniec's avatar

anniec

9 months ago · Dry Skin
Review

I had small bumps everywhere and my skin is quite sensitive but this worked very well. It made my skin almost completely smooth. The only thing it...

I had small bumps everywhere and my skin is quite sensitive but this worked very well. It made my skin almost completely smooth. The only thing it didn't fix was the stubborn closed comedones on my jaw and chin which wont go away no matter what.