La Roche-Posay Toleriane Dermallergo Eye Cream Versus La Roche-Posay Toleriane Dermallergo Night Moisturizer
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningGlycerin
HumectantButylene Glycol
HumectantPropanediol
SolventSqualane
EmollientButyrospermum Parkii Butter
Skin ConditioningPentylene Glycol
Skin ConditioningNiacinamide
SmoothingCellulose
AbsorbentZea Mays Starch
AbsorbentPolysorbate 20
EmulsifyingSalvia Miltiorrhiza Root Extract
Skin ConditioningGlyceryl Acrylate/Acrylic Acid Copolymer
HumectantSphingomonas Ferment Extract
Skin ConditioningAmmonium Polyacryloyldimethyl Taurate
Emulsion StabilisingHydroxyacetophenone
AntioxidantCitric Acid
BufferingTrisodium Ethylenediamine Disuccinate
Acetyl Dipeptide-1 Cetyl Ester
Skin ConditioningWater, Glycerin, Butylene Glycol, Propanediol, Squalane, Butyrospermum Parkii Butter, Pentylene Glycol, Niacinamide, Cellulose, Zea Mays Starch, Polysorbate 20, Salvia Miltiorrhiza Root Extract, Glyceryl Acrylate/Acrylic Acid Copolymer, Sphingomonas Ferment Extract, Ammonium Polyacryloyldimethyl Taurate, Hydroxyacetophenone, Citric Acid, Trisodium Ethylenediamine Disuccinate, Acetyl Dipeptide-1 Cetyl Ester
Water
Skin ConditioningGlycerin
HumectantButylene Glycol
HumectantPropanediol
SolventButyrospermum Parkii Butter
Skin ConditioningPentylene Glycol
Skin ConditioningSqualane
EmollientNiacinamide
SmoothingAmmonium Polyacryloyldimethyl Taurate
Emulsion StabilisingPyridoxine Hcl
Skin ConditioningPolysorbate 20
EmulsifyingZea Mays Starch
AbsorbentSalvia Miltiorrhiza Root Extract
Skin ConditioningAllantoin
Skin ConditioningGlyceryl Acrylate/Acrylic Acid Copolymer
HumectantSodium Hydroxide
BufferingSphingomonas Ferment Extract
Skin ConditioningHydroxyacetophenone
AntioxidantCaprylyl Glycol
EmollientCitric Acid
BufferingTrisodium Ethylenediamine Disuccinate
Acetyl Dipeptide-1 Cetyl Ester
Skin ConditioningXanthan Gum
EmulsifyingTocopherol
AntioxidantWater, Glycerin, Butylene Glycol, Propanediol, Butyrospermum Parkii Butter, Pentylene Glycol, Squalane, Niacinamide, Ammonium Polyacryloyldimethyl Taurate, Pyridoxine Hcl, Polysorbate 20, Zea Mays Starch, Salvia Miltiorrhiza Root Extract, Allantoin, Glyceryl Acrylate/Acrylic Acid Copolymer, Sodium Hydroxide, Sphingomonas Ferment Extract, Hydroxyacetophenone, Caprylyl Glycol, Citric Acid, Trisodium Ethylenediamine Disuccinate, Acetyl Dipeptide-1 Cetyl Ester, Xanthan Gum, Tocopherol
Reviews
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Dipeptide-1 Cetyl Ester is a peptide composed of amino acids arginine and tyrosine.
This peptide is considered a neurotransmitter peptide, meaning it has pain-relieving and relaxing properties. It has the ability to calm skin irritation from external factors such as chemical stinging or heat.
Neurotransmitter peptides are also often called "botox in a bottle". This is because these peptides have the ability to relax the muscles.
Though relaxing the muscles can prevent expression lines (as we have seen in botox), the studies do not show these peptides to be a botox replacement. The effects of this muscle relaxation is also short-term, as opposed to longer-term results from botox.
Learn more about Acetyl Dipeptide-1 Cetyl EsterAmmonium Polyacryloyldimethyl Taurate is a polymer made from ammonium salts. It works as a thickener, emulsifier, and texture enhancer that gives gel-creams a silky, lightweight feel.
This ingredient is versatile and low-maintenance so manufacturers love working with it.
Typical usage levels in cosmetics are usually low and in the range of 0.015 - 2.3%.
Learn more about Ammonium Polyacryloyldimethyl TaurateButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolThis ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.
Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).
In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).
Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.
Shea butter also contains vitamins A and E which may contribute to antioxidant activity.
While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.
This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.
Learn more about Butyrospermum Parkii ButterCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Read more about some other popular AHA's here:
Learn more about Citric AcidGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinGlyceryl Acrylate/Acrylic Acid Copolymer is made up of glycerin and polyacrylic acid. It helps hydrate your skin as a humectant.
This ingredient forms a hydrogel that delivers moisturizing, water-based ingredients to the skin. It is also used to thicken a product and to give it a smooth texture.
Acrylic acid itself is toxic, but the polymer form (this ingredient) is too large to penetrate skin, making it non-toxic.
Learn more about Glyceryl Acrylate/Acrylic Acid CopolymerHydroxyacetophenone is antioxidant with skin conditioning and soothing properties. It also boosts the efficiency of preservatives.
Though naturally occuring in Norwegian spruce needles, this ingredient is usually synthetically created.
This ingredient is not irritating or sensitizing. Recent research also suggests it may have skin-brightening effects through tyrosinase inhibition.
Learn more about HydroxyacetophenoneNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamidePentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.
This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.
Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.
Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.
Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.
Learn more about Pentylene GlycolPolysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Learn more about Polysorbate 20Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.Ā
Itās often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolWe don't have a description for Salvia Miltiorrhiza Root Extract yet.
This ingredient is created by the fermentation of Sphingomonas, an interesting bacteria. Sphingomonas bacteria use ubiquinone-10 to help them breathe and their cell walls contain ceramides.
Early research suggests that certain skin bacteria, especially Sphingomonas, could play a helpful role in skin health.
In small studies, these bacteria seemed to become more common after regular sun exposure, with one strain showing the ability to resist UV light and reduce stress in skin cells. Another study also linked Sphingomonas to smoother and more supple skin.
While these results sound promising, the research is still in its early stages, and more studies are needed to know how reliable or meaningful these effects really are.
Fun fact: Unlike most microbes, Sphingomonas can survive the wine fermentation process, making it a tiny microbial marker of a wine's unique "terroir", or the environmentās āfingerprintā on the wine.
Like other ferments, this ingredient may not be Malassezia folliculitis safe.
Learn more about Sphingomonas Ferment ExtractSqualane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).
It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.
This is due to how structurally similar it is to what your skin already produces.
Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.
Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.
No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).
Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Though squalane is often called an oil, itās technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.
The term āoil-freeā isnāt regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.
A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.
The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.
Learn more about SqualaneTrisodium Ethylenediamine Disuccinate is used to help stabilize a product.
It is a chelating agent, meaning it helps prevent metal ions from binding to other ingredients. This prevents unwanted reactions in products. Metal ions can come into a product via the water ingredient. They are found in trace amounts and are not known to be harmful.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterZea Mays Starch is starch made from corn. You might know this as cornstarch . It is used to thicken a product. It can replace talc as an absorbent.
The pH of cornstarch is 5.92.
Cornstarch is a common food ingredient used to thicken soups or to make corn syrup.
Learn more about Zea Mays Starch