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The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.

True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).

It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.

Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Due to its large molecule size, it doesn't penetrate beyond the skin's surface.

This ingredient has a solid regulatory track record; the CIR Expert Panel first concluded it was safe for use in cosmetics at concentrations up to 100% in 1997. A 2012 reassessment reaffirmed that finding. Safety studies have also found no irritation or evidence of toxicity.

A 2019 study did find this ingredient to grow Malassezia, so this ingredient may not be fungal acne safe.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

The acidity of our skin is maintained by our glands and skin biome; normal pH level of skin is slightly acidic (~4.75-5.5).

Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

What those sugars do is simple and useful: they hold onto water and form a light film on the skin. That means they boost hydration, add a bit of slip, and leave a soft, cushiony feel.

It also helps with texture and thickness.

You'll see claims about anti-aging and "second skin" effects but those come mostly from supplier marketing.

The real research is cell-culture stuff and there's no human trial on this ingredient specifically (yet). So for now, treat it as a nice hydrator and texture helper, not an active.

Safety-wise, it's pretty solid. The Cosmetic Ingredient Review panel rated it safe as used, human sensitization tests came back negative, and it wasn't irritating in skin or eye tests.

Typical use levels are 0.5% or lower.

You'll see algae listed as a 5/5 on a lot of pore-clogging charts and that number doesn't come from anywhere; it's not in the original rabbit-ear studies that most comedogenic ratings trace back to.

The reasoning behind the reputation is that seaweed is high in iodine and iodine can trigger acne-like breakouts when eaten. This traces back to a 1976 letter in Archives of Dermatology describing two women whose breakouts cleared after they stopped taking high-dose kelp supplements orally.

And the reaction of these two women wasn't clogged pores at all: it was an iodine-triggered pustular rash. Later research found normal dietary iodine doesn't meaningfully affect acne either and nobody has shown topical algae delivers enough iodine to matter.

What we do have is dozens of brown and red algae ingredients found to be non-irritating and non-sensitizing, and a handful of studies that found algae compounds may actually help acne.

However, plenty of people do report breaking out from algae-containing products. Skin is individual and it's worth avoiding if yours has reacted to algae before.

The interesting stuff in there is fucoidan, a type of sulfated sugar polymer, and brown algae polyphenols.

The most cited study took a purified 16 kDa fucoidan fraction from this seaweed and tested it on human skin sections in the lab; results showed that it looks like it can slow down some of the enzymes that chew up collagen and elastin.

None of this is human topical trial so fair to see it as a promising ingredient with a thin clinical file.

Another thing to know is that seaweed composition swings a lot depending on where and when it was harvested, and how it was extracted. Two products with the same INCI can be meaningfully different materials.

Real-world use levels are low, usually between a fraction of a percent and 6%. Just know the raw material that suppliers sell is already diluted, so a "5% seaweed extract" often means a lot less seaweed than what it sounds like. One of the trade materials the CIR reviewed was only 4.7% actual extract in water.

This ingredient has a solid safety record: Human sensitization testing came back negative across a range of 0.5% all the way up to 75% (which is far above anything you would ever put in a product).

It was non-irritating on skin at 4.7%, non-phototoxic, and not genotoxic.

You'll see algae listed as a 5/5 on a lot of pore-clogging charts and that number doesn't come from anywhere; it's not in the original rabbit-ear studies that most comedogenic ratings trace back to.

The reasoning behind the reputation is that seaweed is high in iodine and iodine can trigger acne-like breakouts when eaten. This traces back to a 1976 letter in Archives of Dermatology describing two women whose breakouts cleared after they stopped taking high-dose kelp supplements orally.

And the reaction of these two women wasn't clogged pores at all: it was an iodine-triggered pustular rash. Later research found normal dietary iodine doesn't meaningfully affect acne either and nobody has shown topical algae delivers enough iodine to matter.

What we do have is dozens of brown and red algae ingredients found to be non-irritating and non-sensitizing, and a handful of studies that found algae compounds may actually help acne.

However, plenty of people do report breaking out from algae-containing products. Skin is individual and it's worth avoiding if yours has reacted to algae before.

Now the honest part:

The manufacturer sells this as an anti-seborrhoeic active that calms down oil production and refines the look of pores. This comes from supplier data and not published clinical trials so there is no randomized controlled trial on this ingredient for oiliness, acne, or anything else.

What does exist is one in-vitro study where the extract reduced melanin production in cultured cells + bumped up gluthatione (kind of promising for brightening, but petri dishes are not the same as skin).

The safety profile is the strongest part of this ingredient: human repeat insult patch tests on 50 people came back with zero sensitization. Patch testing at 8% and 16% also showed no irritation at all with only slight irritation when applied neat at 100%

Typical use levels are around 1-3% of the trade material.

You'll see algae listed as a 5/5 on a lot of pore-clogging charts and that number doesn't come from anywhere; it's not in the original rabbit-ear studies that most comedogenic ratings trace back to.

The reasoning behind the reputation is that seaweed is high in iodine and iodine can trigger acne-like breakouts when eaten. This traces back to a 1976 letter in Archives of Dermatology describing two women whose breakouts cleared after they stopped taking high-dose kelp supplements orally.

And the reaction of these two women wasn't clogged pores at all: it was an iodine-triggered pustular rash. Later research found normal dietary iodine doesn't meaningfully affect acne either and nobody has shown topical algae delivers enough iodine to matter.

What we do have is dozens of brown and red algae ingredients found to be non-irritating and non-sensitizing, and a handful of studies that found algae compounds may actually help acne.

However, plenty of people do report breaking out from algae-containing products. Skin is individual and it's worth avoiding if yours has reacted to algae before.

The actual peer reviewed research on it is mostly food science + biochemistry rather than dermatology:

Dulse extracts have shown decent antioxidant activity, and a phenolic dulse extract reduced inflammatory activation in human neutrophils in one study. This supports the "soothing" and "anti-inflammatory" claims you'll see on marketing labels.

Safety-wise, this is one of the better documented algae extracts. The Cosmetic Ingredient Review (CIR) panel formally reviewed it in 2021 and concluded it is safe as used in cosmetics based on its long history of food use plus negative human sensitization patch test data.

Reported use concentrations in leave on products range from well under 1% up to 25% in some formulations.

You'll see algae listed as a 5/5 on a lot of pore-clogging charts and that number doesn't come from anywhere; it's not in the original rabbit-ear studies that most comedogenic ratings trace back to.

The reasoning behind the reputation is that seaweed is high in iodine and iodine can trigger acne-like breakouts when eaten. This traces back to a 1976 letter in Archives of Dermatology describing two women whose breakouts cleared after they stopped taking high-dose kelp supplements orally.

And the reaction of these two women wasn't clogged pores at all: it was an iodine-triggered pustular rash. Later research found normal dietary iodine doesn't meaningfully affect acne either and nobody has shown topical algae delivers enough iodine to matter.

What we do have is dozens of brown and red algae ingredients found to be non-irritating and non-sensitizing, and a handful of studies that found algae compounds may actually help acne.

However, plenty of people do report breaking out from algae-containing products. Skin is individual and it's worth avoiding if yours has reacted to algae before.

Wakame prefers cold and temperate oceans. It is used in Japanese and Korean cuisine (yummy!).

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

This ingredient is also pretty picky about pH; it performs best at pH 6.5 or below.

At the right pH level, sorbic acid is "active" and can slip through the outer wall of a microbe. Once inside, it turns the cell's interior more acidic to shut down the microbe from the inside.

The EU caps this ingredient at 0.6% while the CIR has concluded it's safe at concentrations up to 1%. It's most often used around 0.05-0.2% in cosmetics.

Though this ingredient is considered low-sensitizing and well-tolerated, a very small number of people may have a contact allergy to it. Be sure to patch test if you have a history of allergies towards preservatives.

You'll typically see this ingredient used in very small amounts; anything above 0.001% in a leave-on product or 0.01% in a rinse-off has to be named on the label in the EU. The citrus oils that carry it sit around 0.5-1% in a finished formula.

Fresh limonene is a weak allergen; the real issue is that it slowly reacts with air and then breaks down from oxidation to create hydroperoxides (which are strong sensitizers). This is why suppliers are required to keep the peroxide value below 20 mmol.

Positive reactions in people being investigated for eczema vary:

It's worth skipping if you have a known fragrance allergy or a compromised barrier, but the risk is low for most people.

Older or long-opened products are also more likely to bother you than fresh ones due to oxidation.