Desitin Daily Defense Diaper Rash Cream
A highly rated body treatment with 18 ingredients, including vitamin E.
Body treatment with 18 ingredients that contains Vitamin E
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Zinc Oxide 13%
Cosmetic ColorantWater
Skin ConditioningParaffinum Liquidum
EmollientPetrolatum
EmollientBeeswax
Emulsion StabilisingDimethicone
EmollientSorbitan Sesquioleate
EmulsifyingMicrocrystalline Wax
Emulsion StabilisingPEG-30 Dipolyhydroxystearate
EmulsifyingAloe Barbadensis Leaf Extract
EmollientGlycerin
HumectantTropolone
Skin ConditioningTocopheryl Acetate
Antioxidant1,2-Hexanediol
Skin ConditioningCaprylyl Glycol
EmollientMagnesium Sulfate
Potassium Hydroxide
BufferingPhenoxyethanol
Preservative
Active Ingredients:
Zinc Oxide 13%
Inactive Ingredients:
Water, Paraffinum Liquidum, Petrolatum, Beeswax, Dimethicone, Sorbitan Sesquioleate, Microcrystalline Wax, PEG-30 Dipolyhydroxystearate, Aloe Barbadensis Leaf Extract, Glycerin, Tropolone, Tocopheryl Acetate, 1,2-Hexanediol, Caprylyl Glycol, Magnesium Sulfate, Potassium Hydroxide, Phenoxyethanol
Key Ingredients
Benefits
Concerns
Ingredients Explained
Zinc Oxide (ZO) is a mineral broad-spectrum UV filter and the broadest-spectrum filter recognized by the FDA. It covers everything from UVB through to long-wave UVA.
On top of sun protection, it has skin protectant and skin-soothing properties too.
Here's a myth worth busting: mineral filters are usually described as working by "reflecting" or "bouncing" UV off your skin.
That's mostly not true: when researchers actually measured it, ZO and Titanium Dioxide reflect only about 4-5% of UV (less than SPF 2 worth of protection).
The vast majority of the work (~95%) is done by absorption, similar to chemical UV filters. ZO is a semiconductor that absorbs UV photos through its energy band gap.
So the old "physical blocker vs. chemical absorber" framing is really an oversimplification.
Zinc Oxide is one of the most effective broad-spectrum UV filters out there. It protects across UVB, UVA2, and UVA1 with a flat, even absorption curve across the whole UVA-UVB range.
That uniform UVA coverage is its standout feature; titanium dioxide skews more toward UVB as its particle size drops so ZO gives more consistent and extended UVA protection.
It's also very photostable. As an inorganic oxide, ZO doesn't break down in sunlight the way some organic filters can, so it holds up over a day of wear.
This ingredient is gentle and soothing, making it go-to for sunscreens aimed at sensitive skin, rosacea, or ecezma-prone skin, babies, and children.
It's also unlikely to cause the "eye sting" that some sunscreen ingredients are known for, and regulatory agencies broadly consider it non-toxic and safe for topical use.
Beyond sun protection, ZO is also a recognized OTC skin protectant. It forms a breathable barrier that shields skin from moisture and irritation while supporting healing. This is why you'll see it as a classic active in diaper rash creams.
The only downside to ZO is that it can leave a visible white cast, especially on deeper skin tones. This is the main reason mineral sunscreens have historically felt less cosmetically elegant than chemical or hybrid formulas.
Zinc Oxide comes in both non-nano and nano forms. The dividing line is 100nm and anything under is classified as a nanomaterial by the EU.
The nano version scatters less visible light which cuts down white case and gives a lighter, more wearable texture.
Another thing worth understanding about formulation:
Uncoated ZO has some inherent photocatalytic activity. This just means it can generate reactive oxygen species under UV. It's exactly why cosmetic-grade ZO is almost always surface-coated; this coating suppresses that reactivity and improves how the powder disperses and feels.
A well-formulated coated ZO largely sidesteps this issue.
Zinc Oxide is commonly used anywhere from 10% up to the regulatory maximum in sunscreens (25%).
Mineral-only broad-spectrum products often land in the 15-25% range to hit higher SPF and UVA values. Keep in mind SPF performance depends heavily on particle size, dispersion, and the rest of the formula, and not just the percentage.
As an OTC skin protectant like diaper creams, ZO typically runs higher at roughly 10-40%.
This ingredient is generally easy to work with and doesn't photodegrade.
The only thing to know is that uncoated ZO can be a bit reactive in a formula.
Under UV, it can break down sensitive ingredients like other actives or UV filters. This is another reason coated versions are standard. ZO can also react with very acidic ingredients or throw off stability of some creams. A good formula will get around this with the right coatings and dispersion.
The EU's Scientific Committee on Consumer Safety has concluded that ZO nanoparticles "can be considered to not pose any risk of adverse effects in humans after application on healthy, intact or sunburnt skin".
You might hear that ZO is "toxic"; this is because an in-vitro (test tube) study suggested micronized ZO had potential phototoxicity. In vivo (human) investigations have disputed this and the results have come back reassuring.
So does ZO penetrate skin? The short answer is no, not in any way that matters.
The most relevant evidence comes from real-world human studies: in one, volunteers applied ZO nanoparticle sunscreen hourly for six hours and daily for five days. The advanced imaging showed the particles stayed on the surface and never reached the living epidermis, and no cellular toxicity was found.
Other in-vivo and ex-vivo work agree; ZO nanoparticles don't cross the stratum corneum, even on flexed, massaged, or barrier-impaired skin.
A small amount of solubilized zinc ions can dissolve off the particles and enter the upper skin. But the quantities are tiny compared to the zinc already naturally present in your body, and studies haven't found this to cause local toxicity.
The sunscreen bans you've heard of (like Hawaii's) are aimed at two chemical filters, Oxybenzone and Octinoxate. ZO itself it not banned and is often recommended instead.
So far, there's no solid evidence that any form of ZO harms reefs. It is an ongoing and active area of study, and worth keeping an eye on.
If you're traveling somewhere with these rules, a non-nano mineral sunscreen is the safe bet.
Learn more about Zinc OxideWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterParaffinum Liquidum is a highly-refined cosmetic-grade mineral oil. It is also known as liquid paraffin.
Despite its controversial reputation, the science is pretty clear: it's one of the most well-studied and effective moisturizing ingredients out there.
As an occlusive, it forms a protective layer on the skin that locks in moisture and prevents transepidermal water loss (TEWL). This makes it especially great for compromised skin barriers.
The "it clogs your pores" myth has been around for decades; a study found that industrial-grade mineral oil may be comedogenic but cosmetic-grade mineral oil is not (these two are very, very different).
A 2017 review concluded that cosmetic use of mineral oils and waxes does not present a risk to consumers due to absorption.
Mineral oil got a bad rap from the old rabbit ear studies. When tested on actual human skin, cosmetic-grade mineral oil showed no comedogenic activity. The rating of 0 is a correction of outdated science.
Mineral oil is an inert substance with no fatty acids so there's nothing to feed Malassezia. This ingredient is fungal acne safe.
Learn more about Paraffinum LiquidumPetrolatum is more commonly known as petroleum jelly. It is created by mixing waxes and mineral oils.
This ingredient is effective at reducing water loss by 99%. This is because it is an occlusive. Occlusives create a hydrophobic barrier on the skin to prevent evaporation. This property makes it great for hydrating dry skin.
Pro tip: Use occlusives, such as this ingredient, on damp skin for the best results.
The quality or origin of petrolatum is only known when disclosed by the brand. Most cosmetic petrolatum has gone through several purification stages.
Another benefit of occlusives is it protects your skin against infection or allergies.
Petrolatum is fungal acne safe. It is a hydrocarbon with no fatty acid structure, so Malassezia cannot metabolize it. In-vitro studies support negligible growth stimulation as well.
It's also worth noting that petrolatum has a comedogenic rating of 0. In updated rabbit ear testing (and in human testing), petrolatum was found to be not comedogenic. This means it didn’t promote comedone formation in standard models.
Learn more about PetrolatumBeeswax is natural wax produced by honey bees to build their honeycomb.
Because it forms a protective layer on your skin, it can help lock in moisture and reduce water loss. It is also widely used as a thickener and emulsifier in lip balms and lotions. Research suggests beeswax containing moisturizers can support skin barrier integrity.
In comedogenic testing, Beeswax scored a 0-2, which is on the low end. Whether or not a product clogs your pores really comes down to the formula as a whole (not any single ingredient on its own).
Cera Alba is the white, bleached form of this ingredient.
Just so you know, beeswax is not vegan since it is animal-derived. It cannot be removed with water, but can be taken off with an oil cleanser.
People with a known Propolis allergy also report to have reactions from beeswax.
Beeswax's wax esters are derived primarily from palmitic and oleic acid (C16 and C18:1). Both of these fall within the C11-C24 feeding window.
The Malassezia yeast can potentially cleave these esters and release usable fatty acids, so this ingredient may not be fungal acne safe. However, not everyone will react to this ingredient.
Learn more about BeeswaxDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeSorbitan Sesquioleate is derived from sorbitol and oleic acid. It is an emulsifier and prevents ingredients from separating.
Specifically, this ingredient is a water-in-oil emulsifier, meaning it helps water dissolve into oil.
Some studies suggest this ingredient may cause irritation in some people. If you are unsure, it is best to patch test.
This ingredient may not be Malassezia folliculitis, or fungal-acne safe due to the oleic acid. In vitro studies have shown that Oleic Acid is one of the fatty acids that induce rapid Malassezia growth in lab settings.
Learn more about Sorbitan SesquioleateMicrocrystalline Wax is derived from petroleum through a de-oiling process, then highly refined and purified before use in cosmetics.
In skincare formulations, it is used to improve texture and create a smooth, even consistency. It also helps stabilize products by preventing ingredients from separating.
This ingredient is an emulsifier that keeps the oily and watery parts of a formula blended together. Its real party trick is making thin, flowable, and very stable emulsions.
Typical use sits around 2-4% (a bit higher for sunscreens and foundations).
The Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe in cosmetics and noted the large molecules aren't likely to be absorbed into skin.
Because it carries a fatty-acid ester component (stearic acid), it may not be fungal acne safe.
Learn more about PEG-30 DipolyhydroxystearateAloe Barbadensis Leaf Extract is a botanical extract pulled from the leaves of aloe vera and one of the most studied plant ingredients in cosmetics.
The inner leaf gel it comes from is mostly water (~99-99.5%) and the remaining fraction is made up of pretty good stuff: polysaccharides, vitamins, phenolics, and enzymes.
Its headline job is hydration.
The star polysaccharide in aloe, acemannan, is a humectant that retains moisture and helps reduce trans-epidermal water loss.
Aloe also has real soothing credentials; it contains anti-inflammatory compounds like bradykinase and C-glucosyl chromone that help calm irritation and redness.
On the repair side, lab work shows that acemannan wakes up your skin's repair cells (fibroblasts), prompting them to multiply and speed up healing.
There's some human data for cosmetic benefit too: a cream containing 10% Aloe Barbadensis leaf extract improved skin hydration and elasticity in a real-use study.
Safety-wise, this ingredient is well-regarded with just one rare downside; there have been some case reports of acute eczema, contact urticaria, and dermatitis in people who applied aloe-derived ingredients topically. Those with a known aloe or Liliaceae sensitivity should patch test.
Typical use levels range widely, from under 1% up to 90%+ depending on the format and the effect you are after.
Learn more about Aloe Barbadensis Leaf ExtractGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinWe don't have a description for Tropolone yet.
Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Learn more about Tocopheryl Acetate1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolMagnesium Sulfate is a salt. More specifically, it is an epsom salt, or the bath salt used to help relieve muscle aches.
Despite having ‘sulfate’ in the name, it isn’t a surfactant or cleansing agent like sodium lauryl sulfate. Unlike those sulfates, magnesium sulfate doesn’t have the same cleansing or foaming properties (it's simply a type of salt).
In cosmetics, Magnesium Sulfate is used to thicken a product or help dilute other solids. It is a non-reactive and non-irritating ingredient.
One study shows magnesium deficiency may lead to inflammation of the skin. Applying magnesium topically may help reduce inflammation.
You can find this ingredient in sea water or mineral deposits.
Learn more about Magnesium SulfatePotassium hydroxide is commonly known as caustic potash. It is used to fix the pH of a product or as a cleaning agent in soap. In cleansers, it is used for the saponification of oils.
Sapnification is the process of creating fatty acid metal salts from triglycerides and a strong base. During this process, Potassium Hydroxide is used up and is not present in the final product.
Using high concentrations of Potassium Hydroxide have shown to irritate the skin.
Learn more about Potassium HydroxidePhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about PhenoxyethanolReviews
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