ZO Skin Health Growth Factor Serum
A highly rated serum with 34 ingredients, including vitamin E and peptides.
Overview
What it is
Serum with 34 ingredients that contains peptides and Vitamin E
Cool Features
It is cruelty-free and reef safe
Suited For
It has ingredients that are good for anti aging, dry skin, brightening skin, sensitive skin, scar healing and dark spots
Free From
It doesn't contain any harsh alcohols, common allergens, oils, parabens or sulfates
Fun facts
ZO Skin Health is from United States. This product is used in 184 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Water
Skin ConditioningCyclopentasiloxane
EmollientDipropylene Glycol
HumectantPropylene Glycol
HumectantDimethicone
EmollientGlycerin
HumectantDimethicone Crosspolymer
Emulsion StabilisingDimethicone/PEG-10/15 Crosspolymer
PEG-12 Dimethicone Crosspolymer
EmulsifyingButylene Glycol
HumectantDimethicone/Vinyl Dimethicone Crosspolymer
Skin ConditioningSodium Phosphate
BufferingPanthenyl Triacetate
Phospholipids
Skin ConditioningMagnesium Sulfate
Hydrolyzed Sericin
Skin ConditioningEthyl Linoleate
EmollientBuddleja Davidii Meristem Cell Culture
Skin ConditioningAngelica Polymorpha Sinensis Root Extract
Skin ConditioningDipeptide Diaminobutyroyl Benzylamide Diacetate
Skin ConditioningLactobacillus/Panax Ginseng Root Extract Ferment Filtrate
Skin ConditioningDisodium Acetyl Glucosamine Phosphate
Skin ConditioningAcetyl Tyrosine
Skin ConditioningDimethiconol
EmollientOleyl Alcohol
EmollientProline
Skin ConditioningParfum
MaskingTocopherol
AntioxidantBeta-Glucan
Skin ConditioningAdenosine Triphosphate
Skin ConditioningHydrolyzed Vegetable Protein
Skin ConditioningSodium Chloride
MaskingXanthan Gum
EmulsifyingPhenoxyethanol
PreservativeWater, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, PEG-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Phospholipids, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus/Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Parfum, Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Vegetable Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterCyclopentasiloxane, or D5, is a silicone used to improve texture of products and trap moisture.
D5 is considered lightweight and volatile. Volatile means it evaporates quickly after application. Once evaporated, D5 leaves a thin barrier that helps keep skin hydrated.
It is also an emollient. Emollients help soften the skin and prevent water loss. Silicones create a silky texture in products. D5 helps other ingredients become more spreadable.
Studies show D5 is safe to use in skincare products. We recommend speaking with a skincare professional if you have concerns.
Learn more about CyclopentasiloxaneDipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.
This ingredient helps:
Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the āgoodā alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.
As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.
Studies show Dipropylene Glycol is considered safe to use in skincare.
Learn more about Dipropylene GlycolPropylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.
As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.
The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.
True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).
It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.
Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.
Learn more about Propylene GlycolDimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinDimethicone Crosspolymer is a silicone created by modifying dimethicone with hydrocarbon side chains. Due to its large size, it does not penetrate skin. It is considered non-occlusive.
Dimethicone Crosspolymer is used to stabilize and thicken products. It also helps give products a silky feel.
This is a silicone-based ingredient that helps create a smooth, silky, "bouncy" texture. It also acts as an emulsifier that prevents ingredients from separating in a formula.
Due to its large molecule size and water-insolubility, this ingredient is unlikely to be absorbed into skin. Irritation and sensitization tests have found reactions to silicones are considered very rare.
You'll likely see this ingredient in leave-on products at concentrations of 0.03%-3%.
Learn more about Dimethicone/PEG-10/15 CrosspolymerPEG-12 Dimethicone Crosspolymer is a type of silicone.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolThis ingredient is a silicone elastomer that works as a texture enhancer, adds a silky slip, and also helps absorb excess oil.
Because it's a large macromolecule that's insoluble in water and chemically inert, it's not expected to penetrate or be absorbed into skin.
Human patch tests with a facial lotion containing 1% of this ingredient found no sensitization.
Learn more about Dimethicone/Vinyl Dimethicone CrosspolymerSodium Phosphate is is behind-the-scenes formulation helper. Its main job is buffering, or locking in the product's pH.
This helps ensure the formula stays at its intended acidity through manufacturing, shipping, and sitting on your shelf. Many active ingredients like vitamin C or retinoids are pH sensitive so maintaining their happy pH range matters.
It is synthetic and reported use concentrations are very low (up to 0.086% in face powders).
Learn more about Sodium PhosphateWe don't have a description for Panthenyl Triacetate yet.
Phospholipids are a family of skin-identical lipids that makeup the structural backbone of every cell membrane in your body.
In cosmetics, they function as skin conditioning agents with emulsifier and surfactant properties. They're typically sourced from soybean or sunflower lecithin (or sometimes egg yolk or marine sources).
Because they mirror the lipids naturally found in the deeper layers of your skin, topical phospholipids help reinforce the lipid matrix, reduce transepidermal water loss, and leave skin feeling conditioned.
They're also used to form liposomes, or tiny self-assembling vesible used to stabilize actives like vitamin c or retinol. This helps these ingredients integrate into the upper layers of skin more easily.
Phospholipids are compatible with everything and the CIR Expert Panel has concluded them to be safe at current use levels.
This ingredient may not be fungal acne safe since phospholipids contain fatty acid chains in the C11-24 range that the malassezia yeast likes to feed on.
Some types of phospholipids include:
Learn more about PhospholipidsMagnesium Sulfate is a salt. More specifically, it is an epsom salt, or the bath salt used to help relieve muscle aches.
Despite having āsulfateā in the name, it isnāt a surfactant or cleansing agent like sodium lauryl sulfate. Unlike those sulfates, magnesium sulfate doesnāt have the same cleansing or foaming properties (it's simply a type of salt).
In cosmetics, Magnesium Sulfate is used to thicken a product or help dilute other solids. It is a non-reactive and non-irritating ingredient.
One study shows magnesium deficiency may lead to inflammation of the skin. Applying magnesium topically may help reduce inflammation.
You can find this ingredient in sea water or mineral deposits.
Learn more about Magnesium SulfateWe don't have a description for Hydrolyzed Sericin yet.
Ethyl Linoleate is a fragrance and isn't fungal acne safe.
We don't have a description for Buddleja Davidii Meristem Cell Culture yet.
We don't have a description for Angelica Polymorpha Sinensis Root Extract yet.
This small molecule peptide has similar benefits to Argireline, the "botox" peptide.
According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.
While this seems promising, research is lacking in proving this ingredient to be as effective as botox.
Learn more about Dipeptide Diaminobutyroyl Benzylamide DiacetateWe don't have a description for Lactobacillus/Panax Ginseng Root Extract Ferment Filtrate yet.
We don't have a description for Disodium Acetyl Glucosamine Phosphate yet.
We don't have a description for Acetyl Tyrosine yet.
Dimethiconol is a silicone that resembles the popular dimethicone. Like other silicones, it is an emollient. Emollients create a thin film on skin to prevent moisture from escaping.
This ingredient helps to create a silky texture and improve spreadability. Due to its high molecular weight and thickness, it is often combined with cyclopentasiloxane.
Oleyl Alcohol is a type of fatty alcohol made from oleic acid.
Fatty Alcohols are most often used as an emollient or to thicken a product. They are usually derived from natural fats and oils and therefore do not have the same drying or irritating effect as solvent alcohols.
Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.
It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.
Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.
Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.
Learn more about ProlineParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of āFRAGRANCEā or āPARFUMā according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skinās lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolBeta-Glucan is a polysaccharide. It can be derived from the cell walls of seaweed, oats, yeast, and fungi. It hydrates the skin and helps boost your skin's natural barrier.
As an antioxidant, beta-glucan helps fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.
Studies show this ingredient may be an effective wrinkle reducer as it can deeply penetrate into skin. It has also been show to help with wound healing.
Learn more about Beta-GlucanAdenosine Triphosphate is from the hydrolysis of nucleic acids in yeast. It comes from adenosine, one of the four building blocks for RNA.
Our bodies use Adenosine Triphosphate for energy at the cellular level.
It is an antioxidant. Antioxidants help fight off damage from free-radical molecules.
Adenosine Triphosphate may help with reducing irritation.
Learn more about Adenosine TriphosphateWe don't have a description for Hydrolyzed Vegetable Protein yet.
Chances are, you eat sodium chloride every day. Sodium Chloride is also known as table salt. This ingredient has many purposes in skincare: thickener, emulsifier, and exfoliator.
You'll most likely find this ingredient in cleansers where it is used to create a gel-like texture. As an emulsifier, it also prevents ingredients from separating.
You might see people debate whether Sodium Chloride is comedogenic, but there actually haven't been any comedogenic tests done on it. Either way, the overall formulation of a product matters a lot more than any single ingredient.
You might see this ingredient used in scrubs as a primary exfoliating ingredient.
Learn more about Sodium ChlorideXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Reviews
Where it's from
ZO Skin Health is a American brand
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The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about usĀ· Updated June 12, 2025 • Added by skincaresnob