Versus

Differin 0.1% w/w Cream Versus Galderma Differin Cream

Facial Treatment
Prescription
American Brand United States
Swiss Brand Switzerland

Updated on January 20, 2025

Overview

Cool Features

They both contain retinoid

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, oily skin, reducing pores, scar healing and better texture

Free From

They both do not contain any harsh alcohols, common allergens, fragrances, oils or sulfates

What's Inside

They both contain parabens

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

Differin 0.1% w/w Cream 12 ingredients

Galderma Differin Cream 10 ingredients

About this product

About this product

At a glance

Click on any of the items below to learn more

Differin 0.1% w/w Cream 12 ingredients

Galderma Differin Cream 10 ingredients

Key Ingredients

Benefits

Concerns

Key Ingredients

Benefits

Concerns

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Adapalene is a type of retinoid and common acne treatment.

It has been found to be as effective as other retinoids while causing less irritation.

Retinoids are the gold-standard for anti-aging due to the decades of research backing up their benefits:

You can buy adapalene over the counter, or in-store, in concentrations of 0.1% in gel form. 0.1% lotion or cream and 0.3% gel are only available with a prescription.

Learn more about Adapalene
Emulsion Stabilising, Gel Forming

Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.

A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.

PEG-20 Methyl Glucose Sesquistearate isn't fungal acne safe.

Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emollient, Skin Conditioning

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.

Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.

Research shows that squalane is non-irritating (even at 100% concentration).

In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.

The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.

Is squalane vegan?

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Learn more about Squalane
Preservative

Propylparaben is a preservative and is a paraben with antifungal and antimicrobial properties.

This ingredient can be naturally found in plants and insects, but most of it is synthetically manufactured for human use. In cosmetics, it is usually created by reacting para-aminobenzoic acid and propanol (an alcohol).

You can usually find this ingredient in water-based products.

Parabens have come under controversy due to the claim they are hormone disruptors. Studies show conflicting results. We recommend speaking with a professional if you have any concerns.

Propylparaben is commonly found in food, medicine, and cosmetics.

Learn more about Propylparaben

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA
Emollient, Emulsifying, Skin Conditioning

Methyl Glucose Sesquistearate isn't fungal acne safe.

Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Ingredient Ratings

Here's what our community thinks of the ingredients in these products.

When to use

Differin 0.1% w/w Cream 12 ingredients

Galderma Differin Cream 10 ingredients

229 Routines
9% use in am
91% use in pm
80% use every day
When to use See routines that use it ->
226 Routines
7% use in am
93% use in pm
73% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Differin 0.1% w/w Cream 12 ingredients

3.7 /5
from 3 ratings
Absorbs Well (1) Great Value (1) Light (1)
oumoukadamzachrisson's avatar

Oumou Kadam-Zachrisson

4 months ago
Review

With consistency and patience differin is definitely a reliable and effective treatment for acne. I use this every evening and since I started (about 1,5 years ago I believe now) it has shown great results. I debated putting a 5 star rating but because it do take quite some time and has yet to completely get rid of my acne I put a 4.

𝘌𝘹𝘵𝘳𝘢:
I was previously prescribed with epiduo which ended Show more

#great value
#light
#absorbs well
#no scent

Galderma Differin Cream 10 ingredients

4.5 /5
from 4 ratings
Works Well (4) No Scent (3) Absorbs Well (2)
ChienYun_CY's avatar

Chien Yun Ang

9 months ago
Review

This cream is prescribed to me and I LOVE it. It isn't drying for me and I don't suffer any side effects from using it. I only need a fairly thin layer of this cream on my affected areas. It cleared up most possible developing whiteheads for me and leave my skin really bright and even.

#absorbs well
#no scent
#works well
Khang69's avatar

K

3 months ago
Review

I used this as a spot treatment for my stubborn/hidden acne and allergy pimples. It works great and the result might be visible after 1 or 2 days of use. The problem is it burned the area when I applied the cream with redness, it took weeks to get rid of the redness

#great value
#absorbs well
#no scent
#works well