When (and how) to use 0.1% Cream by Differin

Last updated on July 05, 2025.

Overview

Welcome to our guide on when (and how) to use Differin 0.1% Cream.

When to use

We recommend using this product in the evening. In fact, 94% of routines created by our community use it in the evening.

How often

73% of routines created by our community use this product every day.

In your routine

This product is most commonly used as step 4 in a routine. Use our Routine Creator to see where you should use this product in your routine.

Fun Fact

272 routines created by our community use this product.

We independently verify product and ingredient data. Spot something that seems off? Let us know.

Pair it with

Learn more about the ingredients in this product
Check out our complete breakdown of the ingredients and their benefits/drawbacks

Routine inspiration

Learn more

Check out our complete guide to the ingredients in Differin 0.1% Cream.

See the full ingredient explanation