Is Clinical GeneXC Serum

Glycolic acid is a derivative of sugarcane. While glycolic acid is an AHA with exfoliating properties, sugarcane is not an AHA.

A study from 2021 found the compounds in sugarcane extract to have antioxidant, antimicrobial, and anti-inflammatory activity. The study also suggests these compounds can inhibit skin ageing enzymes and promote collagen synthesis.

Due to its antioxidant properties, trehalose may help with signs of aging. Antioxidants help fight free-radical molecules, unstable molecules that may damage your skin.

In medicine, trehalose and hyaluronic acid are used to help treat dry eyes.

Some animals, plants, and bacteria create trehalose as a source of energy to survive freeze or lack of water.

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.

Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.

Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.

Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.

The high vitamin C content of Kakadu plum also helps lighten skin. Vitamin C has been shown to block the process of skin darkening that leads to hyperpigmentation.

Kakadu plums have been used by indigenous cultures as medicine to help treat colds and as an antiseptic.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.

Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.

It can also be mildly exfoliating due to the citric acid, an AHA.

Citrus fruits are rich in flavonoids, alkaloids, and vitamin C.

Last, the phytochemicals found in apples are strong antioxidants. These antioxidants help with anti-aging as they protect your skin cells against oxidative damage.

Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside.

In lab-grown skin models, this translated to younger, healthier, and stronger skin.

There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection.

Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums.

A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity.

The quality of the extract matters a lot here:

Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients.

Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water).

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

It is an antioxidant. Antioxidants help fight off damage from free-radical molecules.

Adenosine Triphosphate may help with reducing irritation.

Like SOD, EUK-134 specifically targets superoxide anions and pro-oxidant molecules.
EUK-134 is able to transform ROS (reactive oxygen species) into water and oxygen while destroying hydrogen peroxide.

Our cells create ROS as a byproduct of every day cell activity. Studies show overproduction of ROS is linked to inflammation and aging.

Why is there hydrogen peroxide in our cells? Our bodies produce hydrogen peroxide as a natural defense against superoxide.

Superoxide is a reactive form of oxygen ion that damages our cells. It is toxic in high concentrations, hence why our bodies produce hydrogen peroxide to protect itself.

However, this hydrogen peroxide is a double-edged sword. While it protects us against superoxide, hydrogen peroxide is corrosive on skin. It is also linked to the aging process.

This is where EUK-134 comes in: it can neutralize superoxide and hydrogen peroxide, making it a great anti-aging ingredient.