Skin Actives Scientific Antioxidant Serum Versus Skin Actives Scientific Collagen Serum with ROS BioNet and Apocynin
This anti-aging serum is formulated around Magnesium Ascorbyl Phosphate and Ferulic Acid to soften the look of wrinkles and brighten dull-looking skin.
This anti-aging serum is formulated around Sh-Oligopeptide-1 to soften the look of wrinkles and fade the look of dark spots.
What's inside
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningLactobacillus/Kelp Ferment Filtrate
Skin ConditioningSodium PCA
HumectantMagnesium Ascorbyl Phosphate
AntioxidantSodium Hyaluronate
HumectantFerulic Acid
AntimicrobialAloe Barbadensis Leaf Extract
EmollientCamellia Sinensis Catechins
AntioxidantNiacinamide
SmoothingCarnosine
Skin ConditioningHesperidin Methyl Chalcone
AntioxidantCarnitine
CleansingTetrahydrodiferuloylmethane
AntioxidantTetrahydrodemethoxydiferuloylmethane
AntioxidantTetrahydrobisdemethoxydiferuloylmethane
AntioxidantSorghum Bicolor Leaf/Stem Extract
Skin ConditioningLycopene
AntioxidantAstaxanthin
Skin ConditioningFucoxanthin
Skin ConditioningPorphyridium Polysaccharide
AntioxidantGlutathione
Sh-Polypeptide-2
Skin ConditioningSh-Polypeptide-77
Skin ConditioningSuperoxide Dismutase
AntioxidantCitric Acid
BufferingPropylene Glycol
HumectantDiazolidinyl Urea
PreservativeMethylparaben
PreservativePropylparaben
PreservativeWater, Lactobacillus/Kelp Ferment Filtrate, Sodium PCA, Magnesium Ascorbyl Phosphate, Sodium Hyaluronate, Ferulic Acid, Aloe Barbadensis Leaf Extract, Camellia Sinensis Catechins, Niacinamide, Carnosine, Hesperidin Methyl Chalcone, Carnitine, Tetrahydrodiferuloylmethane, Tetrahydrodemethoxydiferuloylmethane, Tetrahydrobisdemethoxydiferuloylmethane, Sorghum Bicolor Leaf/Stem Extract, Lycopene, Astaxanthin, Fucoxanthin, Porphyridium Polysaccharide, Glutathione, Sh-Polypeptide-2, Sh-Polypeptide-77, Superoxide Dismutase, Citric Acid, Propylene Glycol, Diazolidinyl Urea, Methylparaben, Propylparaben
Water
Skin ConditioningLactobacillus/Nereocystis Leutkeana Ferment Filtrate
Skin ConditioningGlycerin
HumectantSodium PCA
HumectantMagnesium Ascorbyl Phosphate
AntioxidantHydrolyzed Collagen
EmollientApocynin
Skin ConditioningSodium Hyaluronate
HumectantBoswellia Serrata Extract
Skin ConditioningCentella Asiatica Extract
CleansingSh-Polypeptide-2
Skin ConditioningSh-Oligopeptide-1
Skin ConditioningSh-Polypeptide-77
Skin ConditioningSuperoxide Dismutase
AntioxidantCarnosine
Skin ConditioningAcetyl Glucosamine
Skin ConditioningNiacinamide
SmoothingBetulinic Acid
Skin ConditioningCamellia Sinensis Leaf Extract
AntimicrobialEpigallocatechin Gallate
AntioxidantGlutathione
Polysorbate 20
EmulsifyingCitric Acid
BufferingPhenoxyethanol
PreservativeCaprylyl Glycol
EmollientSorbic Acid
PreservativeWater, Lactobacillus/Nereocystis Leutkeana Ferment Filtrate, Glycerin, Sodium PCA, Magnesium Ascorbyl Phosphate, Hydrolyzed Collagen, Apocynin, Sodium Hyaluronate, Boswellia Serrata Extract, Centella Asiatica Extract, Sh-Polypeptide-2, Sh-Oligopeptide-1, Sh-Polypeptide-77, Superoxide Dismutase, Carnosine, Acetyl Glucosamine, Niacinamide, Betulinic Acid, Camellia Sinensis Leaf Extract, Epigallocatechin Gallate, Glutathione, Polysorbate 20, Citric Acid, Phenoxyethanol, Caprylyl Glycol, Sorbic Acid
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Carnosine is a dipeptide made from two amino acids.
This ingredient helps:
Glycation is the process of sugars binding to and damaging proteins. Too much sugar in our skin can lead to damaged collagen, contributing to factors of aging.
Carnosine is water-soluble and is not able to travel deeper layers of skin. This leads to some doubt about whether it can boost collagen in skin, since collagen is located in the deeper layers of skin.
Fun fact: Carnosine can be naturally found in our muscles and brain.
Learn more about CarnosineCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Read more about some other popular AHA's here:
Learn more about Citric AcidGlutathione is a tiny protein-like molecule (a "tripeptide" build from 3 amino acids: glycine, cysteine, and glutamic acid) that your body already makes on its own.
Inside your body, it acts as one of the skin's main antioxidants that help fight against free radicals.
In skincare, it's best known as a brightening ingredient that slows down tyrosinase, the key enzyme that makes skin pigment. It also nudges the skin toward making a lighter type of pigment instead of a darker one.
This is why you'll see it in products aimed at dark spots and uneven tone.
A small number of real human trials have found a topical glutathione lotion:
The honest caveat is that the current evidence is still thin (few studies, small groups, short timelines). Glutathione also doesn't absorb into skin very easily so results tend to be modest and fade if you stop using it.
One thing worth clearing up:
The scary side effects you may have heard about come from glutathione injected intravenously, which has real safety concerns. Applying it topically is a completely different thing and has a clean track record.
Most human studies used it around 2% (as Glutathione or Glutathione Disulfide) and a 2% oxidized glutathione lotion and a 2% S-acyl glutathione cream are the concentrations with actual clinical data behind them.
There's no established "ideal" percentage yet but 1-2% is the evidence-backed range.
Allergy-wise, there is very low risk for this ingredient; it was well-tolerated across the topical trials. Only one participant had mild temporary redness that cleared up on its own and another study reported no adverse reactions at all.
One trial had ~10% of users drop out for irritation was using a combination cream that also had 10% azelaic acid so the irritation likely wasn't from the glutathione. There's no notable contact-allergy signal for topical glutathione in the literature but patch-testing before first use is still sensible for those with sensitive skin.
Learn more about GlutathioneMagnesium Ascorbyl Phosphate (MAP) is a water-soluble form of Vitamin C. It is used in skincare because it tends to be more formulation friendly than pure vitamin C (ascorbic acid).
According to research, MAP has three major benefits:
While MAP is gentler on the skin than ascorbic acid, it is thought to be less easily absorbed into the skin.
In a well-known absorption study, pure vitamin C increased skin vitamin C levels when formulated correctly, but derivatives like MAP did not in that experiment. This suggests MAP may not always convert into active vitamin C in the skin.
Due to MAP's stability up to a pH level of 7, it is more stable to air and sunlight exposure than ascorbic acid. The best pH range for MAP is between 5 and 6.
Learn more about Magnesium Ascorbyl PhosphateNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideSh-Polypeptide-2 is a peptide.
Sh-Polypeptide-77 is a peptide.
Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronateSodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.
Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.
As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.
There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.
Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.
It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.
Learn more about Sodium PCASuperoxide Dismutase is found in all living cells. This ingredient is AKA as 'SOD'.
SOD is a strong antioxidant. It protects living cells against oxidative damage by breaking down radical molecules into regular oxygen and hydrogen peroxide.
Antioxidants help fight free-radical molecules that may damage your skin's DNA. This may help with the signs of aging. Due to its antioxidant property, it is used to help treat chronic inflammation.
In cosmetics, SOD is usually obtained from marine phytoplankton, bovine liver, horseradish, cantaloupe, and certain bacteria.
The three major families of SOD include: Copper/Zinc, Iron/Manganese, and Nickel.
When eating SOD-rich foods, our bodies break it down into amino acids before absorption. Foods that contain SOD include: melons, citrus, spinach, broccoli, kale, almonds, sunflower seeds, and blue-green algae.
Learn more about Superoxide DismutaseWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about Water