Overview
What it is
Prescription with 18 ingredients that contains exfoliants
Suited For
It has ingredients that are good for dry skin
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances or sulfates
Fun facts
Opzelura is from United States.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Ruxolitinib
Cetyl Alcohol
EmollientDimethicone
EmollientDisodium EDTA
Glyceryl Stearate Se
EmulsifyingParaffinum Liquidum
EmollientCaprylic/Capric Triglyceride
MaskingMethylparaben
PreservativePhenoxyethanol
PreservativePhosphoric Acid
BufferingPolyethylene
AbrasivePolysorbate 20
EmulsifyingPropylene Glycol
HumectantPropylparaben
PreservativeStearyl Alcohol
EmollientWater
Skin ConditioningPetrolatum
EmollientXanthan Gum
EmulsifyingKey Ingredients
Benefits
Concerns
Ingredients Explained
This is not an INCI ingredient; it is medication. Please speak to your doctor about using this ingredient.
Ruxolitinib is a FDA-approved pharmacologic treatment to address repigmentation in vitiligo patients.
Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
Learn more about Cetyl AlcoholDimethicone is a type of synthetic silicone created from natural materials such as quartz.
What it does:
Dimethicone comes in different viscosities:
Depending on the viscosity, dimethicone has different properties.
Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.
This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.
Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.
Learn more about DimethiconeDisodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTAGlyceryl Stearate Se is a self-emulsifying (SE) form of glyceryl stearate. Self-emusifying means this ingredient automatically blends with water. It is an emulsifier, emollient, and cleansing agent.
As an emulsifier, Glyceryl Stearate Se prevents ingredients such as oil and water from separating. It is also a surfactant, meaning it helps cleanse the skin. Surfactants help gather oil, dirt, and other pollutants so they may be rinsed away easily.
Emollients help your skin stay smooth and soft. It does so by creating a film on top of the skin that helps trap moisture in.
Learn more about Glyceryl Stearate SeParaffinum Liquidum is also known as liquid paraffin. It is a type of highly refined mineral oil.
Like other oils, Paraffinum Liquidum has emollient properties. Emollients help soothe and soften the skin. By creating a barrier to trap moisture within, emollients help keep your skin hydrated.
Paraffinum Liquidum does not irritate the skin and is non-comedogenic.
Learn more about Paraffinum LiquidumThis ingredient is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.
It helps thicken a product's formula and makes it easier to spread by dissolving clumping compounds.
Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid.
While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.
Learn more about Caprylic/Capric TriglycerideMethylparaben is a preservative and is a paraben. It is used to prevent the growth of fungus, mold, and other harmful bacteria. Parabens are chemicals used as preservatives in both cosmetics and food.
Methylparaben can be synthetically created. It can also be found naturally in some fruits, such as blueberries.
Oftentimes, Methylparaben is combined with other parabens to help increase the shelf life.
The safety of Methylparaben is currently being studied. While ongoing studies are looking into the safety of parabens, the results have been very mixed. Some studies have not found Methylparaben to be harmful.
Learn more about MethylparabenPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Phosphoric acid is used to adjust the pH of products.
Polyethylene is a synthetic ingredient that helps the skin retain moisture. It is a polymer.
It is also typically used within product formulations to help bind solid ingredients together and thicken oil-based ingredients. When added to balms and emulsions, it helps increase the melting point temperature.
Polysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.
Another role of this ingredient is preventing a product from melting or freezing. Propylene glycol also adds antimicrobrial properties to a product, elongating product lifespan.
This ingredient is considered an organic alcohol and commonly added into both cosmetics and foods.
Those with sensitive skin or conditions may develop a rash when using this ingredient.
Learn more about Propylene GlycolPropylparaben is a preservative and is a paraben with antifungal and antimicrobial properties.
This ingredient can be naturally found in plants and insects, but most of it is synthetically manufactured for human use. In cosmetics, it is usually created by reacting para-aminobenzoic acid and propanol (an alcohol).
You can usually find this ingredient in water-based products.
Parabens have come under controversy due to the claim they are hormone disruptors. Studies show conflicting results. We recommend speaking with a professional if you have any concerns.
Propylparaben is commonly found in food, medicine, and cosmetics.
Learn more about PropylparabenStearyl Alcohol is a type of fatty alcohol from stearic acid. It is a white, waxy compound used to emulsify ingredients.
Fatty Alcohols are most often used as an emollient or to thicken a product. Emollients help soothe and hydrate the skin by trapping moisture.
They are usually derived from natural fats and oils and therefore do not have the same drying or irritating effect as solvent alcohols. FDA allows products labeled "alcohol-free" to have fatty alcohols.
Learn more about Stearyl AlcoholWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterPetrolatum is more commonly known as petroleum jelly. It is created by mixing waxes and mineral oils.
This ingredient is effective at reducing water loss by 99%. This is because it is an occlusive. Occlusives create a hydrophobic barrier on the skin to prevent evaporation. This property makes it great for hydrating dry skin.
Pro tip: Use occlusives, such as this ingredient, on damp skin for the best results.
The quality or origin of petrolatum is only known when disclosed by the brand. Most cosmetic petrolatum has gone through several purification stages.
Another benefit of occlusives is it protects your skin against infection or allergies.
Petrolatum may not be safe for fungal-acne. Studies show mineral oil / petroleum leads to the growth of M. Furfur, a type of yeast.
Learn more about PetrolatumXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumReviews
No written reviews yet. Be the first to review this product.
Where it's from
Opzelura is a American brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about usยท Updated July 30, 2025 • Added by zakiachilds