Differin Dark Spot Correcting Serum 2% Hydroquinone
A serum with 14 ingredients, including AHA.
Overview
What it is
Serum with 14 ingredients that contains AHA
Cool Features
It is vegan and reef safe
Suited For
It has ingredients that are good for dry skin, brightening skin and dark spots
Free From
It doesn't contain any common allergens, parabens, silicones or sulfates
Fun facts
Differin is from United States. This product is used in 46 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Hydroquinone 2%
Stabilising1,2-Hexanediol
Skin ConditioningAlcohol Denat.
AntimicrobialCaprylyl Glycol
EmollientCitric Acid
Buffering
Active Ingredients:
Hydroquinone 2%
Inactive Ingredients:
1,2-Hexanediol, Alcohol Denat., Caprylyl Glycol, Citric Acid, Disodium EDTA, Parfum, Hippophae Rhamnoides Oil, Hydroxyethylcellulose, PEG-40 Hydrogenated Castor Oil, Polysorbate 20, Sodium Metabisulfite, Sodium Sulfite, Water
Key Ingredients
Benefits
Concerns
Ingredients Explained
Hydroquinone is a classic ingredient dermatologists use to fade dark spots (things like melasma, acne marks, sun spots, and freckles).
It works in two ways:
1. By blocking an enzyme called tyrosinase; your skin uses this to make melanin, or the pigment that causes dark spots.
2. By interfering with the pigment making cells themselves so less pigment shows up over time
Just know this ingredient fades spots near the surface of skin and not the deeper ones. It's usually used at 2-4% / twice a day for 3 months, and ALWAYS with sunscreen.
This ingredient is usually well tolerated with short-term use under medical guidance. But possible reactions include irritation, contact dermatitis, and lightening of the skin around the spot you're treating.
You might hear hydroquinone called "cancer-causing". That concern comes from studies where rats were fed high oral doses; no skin cancer cases have been linked to it after more than 50 years of people putting it on their skin.
Long-term, high-strength, and unsupervised use can lead to a condition called ochronosis. This is where the skin turns blue-grey color and sometimes causes nails to turn dark as well.
The rules around it vary by country.
The EU bans it in regular cosmetics and it is prescription only in the US, EU, Japan, Canada, and Australia. Anything you see on the shelf without a prescription is technically not allowed.
Check out the European alternative to hydroquinone here.
SkinSort would like to remind friends from around the world that all skin tones are beautiful!
Learn more about Hydroquinone1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Alcohol Denat. is an alcohol with a denaturant property. It is created by mixing ethanol with other additives.
The "denat" part just means "denatured"; common denaturants include Denatonium Benzoate, t-butyl alcohol, and Diethyl Phthalate. This step makes the alcohol undrinkable (and lets brand skip taxes related to beverage alcohol).
This ingredient gets a bad rep because it is irritating and drying due to its astringent property. Astringents draw out natural oils in tissue to constrict pores and dry out your skin.
However, alcohol denat. is not all that bad.
Due to its low molecular weight, alcohol denat. tends to evaporate quickly. One study on pig skin found half of applied alcohol evaporated in 10 seconds and less than 3% stayed on skin.
This also helps other ingredients become better absorbed upon application.
Studies are conflicted about whether this ingredient causes skin dehydration. One study from 2005 found adding emollients to propanol-based sanitizer decreased skin dryness and irritation. Another study found irritation only occurs if your skin is already damaged.
Small amounts of alcohol are generally tolerated by oily skin or people who live in humid environments.
The rule of thumb is this ingredient will probably not affect your skin much if it is near the end of an ingredients list.
One thing to note:
People with ALDH2 (aldehyde dehydrogenase 2) deficiency may experience skin irritation from continued alcohol use. About 8% of the world's population have this deficiency.
The Cosmetic Ingredient Review Expert Panel has determined denatured alcohols to be safe for use in concentrations between 0.05% and 12% (depending on which denaturant is used).
Also...
This ingredient has antimicrobial and solvent properties.
The antimicrobial property helps preserve products and increase their shelf life. As a solvent, it helps dissolve other ingredients.
Look for formulas that contain glycerin, hyaluronic acid, or panthenol if you want to offset any drying effect.
This ingredient will trip away your skin's natural oils/lipids that help it lock in moisture. This can worsen dryness, trigger eczema flare-ups, and aggravate rosacea.
Be sure to patch test any product with this ingredient if you have dry or sensitive skin, eczema, or rosacea.
Learn more about Alcohol Denat.Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolCitric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.
Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.
However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.
Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.
In skincare formulas, citric acid can:
While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.
Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.
Read more about some other popular AHA's here:
Learn more about Citric AcidDisodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAParfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumHippophae Rhamnoides Oil also known as seabuckthorn oil. This oil is usually extracted from the fruit pulp or seeds.
Seabuckthorn is rich in phytosterols, carotenoids, Vitamins A, C, and E. This gives it strong antioxidant properties that can help soothe and protect your skin from oxidative damage.
This oil is rich in fatty acids, including: two types of linoleic acid (~30-34%), oleic acid (17%), and palmiteic acid (35%). Note these numbers are averages, and different parts of the plant will vary.
Palmitoleic acid has been shown to help soothe inflammation and promote wound healing. It is also naturally found in the fat of our skin.
Overall, seabuckthorn oil is great for nourishing, hydrating, and soothing skin. While it shows UV protecting properties, it should not replace sunscreen.
Due to the rich fatty acid content, this ingredient may not be Malassezia folliculitis, or fungal acne, safe.
Seabuckthorn berries are little orange fruits. This plant is native to Asia.
Learn more about Hippophae Rhamnoides OilHydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.
This ingredient helps stabilize products by preventing ingredients from separating. It can also help thicken the texture of a product.
This ingredient can also be found in pill medicines to help our bodies digest other ingredients.
Learn more about HydroxyethylcellulosePEG-40 Hydrogenated Castor Oil is an emulsifier derived from castor oil.
As an emulsifying agent, it helps other ingredients like fragrances and fat-soluble vitamins dissolve cohesively.
Due to its large molecule size, it doesn't penetrate beyond the skin's surface.
This ingredient has a solid regulatory track record; the CIR Expert Panel first concluded it was safe for use in cosmetics at concentrations up to 100% in 1997. A 2012 reassessment reaffirmed that finding. Safety studies have also found no irritation or evidence of toxicity.
A 2019 study did find this ingredient to grow Malassezia, so this ingredient may not be fungal acne safe.
Learn more about PEG-40 Hydrogenated Castor OilPolysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Learn more about Polysorbate 20Sodium metabisulfite is also known as Sodium Pyrosulfite. It is a preservative, antioxidant, and disinfectant.
As a preservative, it helps stabilize cosmetic formulas without affecting their color or scent.
Sodium Sulfite is a preservative. Preservatives help prevent mold and bacteria from growing in cosmetics.
This ingredient has been shown to break the bonds in hair, acting as a natural straightener.
It is commonly used in food. It should be noted sodium sulfite degrades both vitamins B1 and E.
Fun fact: Sulfites are naturally occuring in wine.
Learn more about Sodium SulfiteWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterReviews
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Where it's from
Differin is a American brand
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The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated May 28, 2025 • Added by BradleyGilbert_15