Galderma TWYNEO cream Versus Galderma Differin 0.1% w/w Cream
Updated on June 03, 2025
Overview
Suited For
They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, oily skin, reducing pores, scar healing and better texture
Free From
They both do not contain any harsh alcohols, common allergens, fragrances, oils or sulfates
What's Inside
They both contain silicones
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Galderma TWYNEO cream 20 ingredients
Galderma Differin 0.1% w/w Cream 12 ingredients
What's inside (and what isn't)
What's inside (and what isn't)
At a glance
Click on any of the items below to learn more
Galderma TWYNEO cream 20 ingredients
Galderma Differin 0.1% w/w Cream 12 ingredients
Key Ingredients
Benefits
Concerns
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Benzoyl Peroxide
Citric Acid
Buffering
BHT
Antioxidant
Carbomer
Emulsion StabilisingCetrimonium Chloride
Antimicrobial
Cetyl Alcohol
Emollient
Cyclomethicone
Emollient
Disodium EDTA
Glycerin
Humectant
Hydrochloric Acid
BufferingImidazolidinyl Urea
Preservative
Lactic Acid
Buffering
Stearyl Stearate
Emollient
PEG-6 Almond Glycerides
Emollient
Polyquaternium-7
Water
Skin ConditioningSilicon
Abrasive
Sodium Hydroxide
BufferingSqualane
Emollient
Tetraethyl Orthosilicate
Benzoyl Peroxide, Citric Acid, BHT, Carbomer, Cetrimonium Chloride, Cetyl Alcohol, Cyclomethicone, Disodium EDTA, Glycerin, Hydrochloric Acid, Imidazolidinyl Urea, Lactic Acid, Stearyl Stearate, PEG-6 Almond Glycerides, Polyquaternium-7, Water, Silicon, Sodium Hydroxide, Squalane, Tetraethyl Orthosilicate
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.
A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.
Cyclomethicone is a class of silicones used to improve the texture of products.
Their cyclic or circular structure decreases stability. This causes quick evaporation when applied to skin. Cyclomethicones are often used as a carrier for other ingredients. Once it evaporates, it leaves a silky barrier on the skin.
The most popular types of cyclomethicones include D5 and D6.
Learn more about CyclomethiconeDisodium EDTA plays a role in making products more stable by aiding other preservatives.
It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.
Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.
Learn more about Disodium EDTAGlycerin is already naturally found in your skin. It helps moisturize and protect your skin.
A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.
As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.
Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.
Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.
In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.
This ingredient is organic, colorless, odorless, and non-toxic.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinSodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.
In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.
Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.
"Alkaline" refers to a high pH level. A low pH level would be considered acidic.
Learn more about Sodium HydroxideSqualane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.
Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.
Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.
Research shows that squalane is non-irritating (even at 100% concentration).
In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.
The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.
Is squalane vegan?
This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.
Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.
Read more about squalene with an "e".
Is squalane an oil?
Squalane is often called an oil, but it’s technically not; it’s a hydrocarbon, meaning it’s only made of carbon and hydrogen, unlike true oils which are triglycerides made of fatty acids and glycerol.
The term “oil-free” isn’t regulated, so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.
While some people avoid oils thinking they cause breakouts, the right kind of oil (or oil-like ingredient like squalane) can actually help balance and hydrate your skin. It’s worth testing out simple oils or squalane to see what works best for your skin.
Learn more about SqualaneWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterIngredient Ratings
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When to use
Galderma TWYNEO cream 20 ingredients
Galderma Differin 0.1% w/w Cream 12 ingredients
Reviews
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