Niod Copper Amino Isolate Serum 3 1:1 (CAIS3)
A highly rated serum with 21 ingredients, including hyaluronic acid and peptides.
Overview
What it is
Serum with 21 ingredients that contains hyaluronic acid and peptides
Cool Features
It is cruelty-free and reef safe
Suited For
It has ingredients that are good for anti aging, dry skin and scar healing
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, oils, parabens, silicones or sulfates
Fun facts
Niod is from Canada. This product is used in 184 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Water
Skin ConditioningGlycerin
HumectantTripeptide-29
Skin ConditioningBis(Tripeptide-1) Copper Acetate
Skin ConditioningTripeptide-1
Skin ConditioningMyristoyl Nonapeptide-3
Skin ConditioningTrifluoroacetyl Tripeptide-2
Skin ConditioningAcetyl Tetrapeptide-2
Skin ConditioningSodium Hyaluronate Crosspolymer
HumectantGlycogen
HumectantPropanediol
SolventPentylene Glycol
Skin ConditioningDextran
Dimethyl Isosorbide
SolventEthoxydiglycol
HumectantIsoceteth-20
EmulsifyingLeuconostoc/Radish Root Ferment Filtrate
AntimicrobialCaprylyl Glycol
EmollientEthylhexylglycerin
Skin ConditioningPhenoxyethanol
PreservativeChlorphenesin
AntimicrobialWater, Glycerin, Tripeptide-29, Bis(Tripeptide-1) Copper Acetate, Tripeptide-1, Myristoyl Nonapeptide-3, Trifluoroacetyl Tripeptide-2, Acetyl Tetrapeptide-2, Sodium Hyaluronate Crosspolymer, Glycogen, Propanediol, Pentylene Glycol, Dextran, Dimethyl Isosorbide, Ethoxydiglycol, Isoceteth-20, Leuconostoc/Radish Root Ferment Filtrate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin
Key Ingredients
Benefits
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinTripeptide-29 is a synthetic peptide designed to support collagen production. It has skin conditioning properties and may help with improving skin texture, fine-lines, and hydration.
Due to its small molecular size, it can easily penetrate skin.
What makes this peptide unique is its purity and availability in a concentrated powder. Traditional peptides are derived from broken-down collagen in a process that produces many random peptides.
The manufacturer's lab tests show 3% of this ingredient increased collagen type I synthesis by 400% within 48 hours. However, this was done in-vitro (not tested on humans).
While the theory behind it is promising, its real-world effectiveness remains unproven, making it an interesting option for skincare enthusiasts but not a guaranteed solution.
Learn more about Tripeptide-29Bis(Tripeptide-1) Copper Acetate is a peptide.
Tripeptide-1, also known as GHK), is a small, three-amino-acid peptide made up of glycine, histidine, and lysine.
This ingredient is a signal peptide and tell your skin to start producing fresh collagen, elastin, and other key structural proteins. This helps maintain firmness and reduces the look of fine-lines/wrinkles.
GHK is also unique because is also acts as a carrier peptide. It binds to and transports copper ions (forming the complex GHK-Cu). This form has been studied for decades and is known to stimulate wound healing, boost antioxidant defenses, and promote collagen/elastin synthesis.
In-vitro studies show both GHK and GHK-CU increase fibroblast activity that enhances the production of collagen, elastin, fibronectin, and other extracellular matrix components.
Both of these compounds also help balance enzymes that control collagen breakdown.
Human studies (in-vivo) using GHK-Cu creams have reported visible improvements to skin density, elasticity, and wrinkle depth after several weeks of use.
A small clinical study also found topical collagen tripeptide improved wrinkle appearance and skin elasticity in women after four weeks.
While these results are promising, most research is based on GHK-Cu or its derivatives rather than Tripeptide-1 alone (Palmitoyl Tripeptide-1 is a famous derivative of GHK). However, the consensus still supports GHK as a potent skin-signaling molecule that can encourage regeneration and maintain youthful looking skin.
Fun fact: GHK is a naturally occurring fragment of type 1 collagen that can be found in human plasma, saliva, and urine.
Learn more about Tripeptide-1Myristoyl Nonapeptide-3 is a peptide.
Trifluoroacetyl Tripeptide-2 is a peptide.
This peptide is more commonly known as Thymulen 4 BG.
It is derived from a youth hormone called thymopoietin. Thymopoietin helps regulate the immune system and decreases naturally with age.
According to the manufacturer, this peptide boosts the skin's immune defenses and regenerates the outer layers of skin.
Learn more about Acetyl Tetrapeptide-2Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.
A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.
A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.
More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.
Learn more about Sodium Hyaluronate CrosspolymerGlycogen is a naturally occurring polysaccharide.
You can find glycogen in our keratinocytes (the cells that produce keratin). It plays an important role in skin hydration and barrier recovery.
Recent research shows topical glycogen can help improve skin moisture, support barrier function, and increase the rate of keratinocyte production. Some studies also suggest this ingredient can protect our skin from oxidative stress.
Biologically, animals and some microorganisms use glycogen as an energy-storage molecule.
This ingredient is usually derived from marine or plant sources, but can sometimes come from animals. We recommend reaching out to the brand if you have questions about the source of their glycogen.
Learn more about GlycogenPropanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.Â
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Learn more about PropanediolPentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.
This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.
Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.
Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.
Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.
Learn more about Pentylene GlycolDextran is a sugar (polysaccharide) with skin hydrating properties.
Fun fact: Louis Pasteur first discovered this ingredient as a microbial product in wine.
Dimethyl Isosorbide is a low-irritation solvent that helps deliver actives into your skin. It is created from glucose.
Research shows how well this ingredient works depends on the active and formulation rather than the concentration alone. This means adding more Dimethyl Isosorbide does not guarantee better penetration of ingredients into the skin.
Ethoxydiglycol is a synthetic solvent.
Solvents are used to keep ingredients together in a product. They can help dissolve ingredients to stable bases or help evenly distribute ingredients throughout the product.
Ethoxydiglycol also helps deliver other key ingredients into the skin.
Learn more about EthoxydiglycolIsoceteth-20 comes from Isocetyl Alcohol. It is an emulsifier. Emulsifiers help stabilize a product. It does this by preventing certain ingredients from separating.
Leuconostoc/Radish Root Ferment Filtrate is a natural preservative. It comes from fermenting radish roots with a bacteria called leuconostoc. The trade name for this ingredient is Leucidal.
Leuconostoc comes from lactic acid.
This ingredient has antimicrobial properties and helps prevent the growth of bacteria in a product.
Leuconostoc is used to make the traditional Korean side-dish, kimchi. It is also used to make sourdough bread (both incredibly yummy foods).
Learn more about Leuconostoc/Radish Root Ferment FiltrateCaprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid or alcohol, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolEthylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Learn more about EthylhexylglycerinPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.
Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.
Chlorphenesin is soluble in both water and glycerin.
Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.
Learn more about ChlorphenesinReviews
Where it's from
Niod is a Canadian brand
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We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Published January 28, 2022 • Added by farogo