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Ingredients higher up in an ingredient list are typically present in a larger amount.
Calendula Officinalis Flower Extract comes from the marigold flower and has been used on skin for centuries for its calming effect.
In the lab, its active compounds appear to calm inflammation and support the early "healing" phase of minor wounds.
This is why Europe's medicines regulator has approved calendula extracts as a traditional remedy for minor skin inflammation and healing small wounds.
The stronger human evidence is around would/ulcer care rather than everyday cosmetic claims; a review that pulled together 14 studies found that calendula helped calm the early, inflamed stage of a wound and helped new skin tissue form faster.
Two studies also showed it shrank leg ulcers (the kind caused by poor circulation). Results were mixed for burns and for the skin irritation people get from radiation treatment, so it's not a sure thing there.
In cosmetics, it's mostly a skin conditioning and soothing agent.
The Cosmetic Ingredient Review panel concluded that calendula-derived ingredients are safe as used and that the ingredients are not irritating, sensitizing, or photosensitizing in clinical tests (though they may be mild eye irritants).
Typical use levels are quite low; industry data reported it used at under 0.5% (one supplier noted a 10-25% extract blend used at 1-10% in the finished product). Historical use goes up to 10%.
The only thing to keep in mind is if you have daisy/ragweed allergies. Calendula is in the same family and one patch-test study found 2% of dermatitis patients reacted to marigold. Be sure to patch test if you have sensitive or allergy-prone skin.
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