Explore Routine Login

Overview

What they are

These products are both reef safe general moisturizers. They have a total of 3 ingredients in common

Suited For

They're both likely to be good for dry skin, brightening skin and sensitive skin

Free From

They both do not contain any harsh alcohols, common allergens, parabens, silicones or sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Dermedic Hydrain3  Ultra-Hydrating Cream-Gel
Dermedic Hydrain3 Ultra-Hydrating Cream-Gel
General Moisturizer
Polish Brand Poland
Physiogel Calming Relief A.I. Cream
Physiogel Calming Relief A.I. Cream
General Moisturizer
German Brand Germany

Ingredient Info

Click any item below to learn more and see relevant ingredients

At a glance

Click on any of the items below to learn more

Notable Ingredients

Benefits

Concerns

Benefits

Concerns

Ingredients Side-by-side

found in both products
Hydrain3 Ultra-Hydrating Cream-Gel
Urea Buffering, Humectant, Skin Conditioning
Helps hydrate Dry Skin IconGood for Skin Texture IconMay worsen Eczema IconMay worsen Rosacea Icon
2 Benefits 2 Concerns

Urea is also called carbamide and is the diamide of carbonic acid. In cosmetics, urea is used to hydrate the skin. It also provides exfoliation in higher concentrations.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Betaine Humectant, Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon
3 Benefits

Betaine is a common humectant (a substance that promotes retention of moisture). It's known to be gentle on the skin and can help balance hydration.

Squalane Emollient, Skin Conditioning
1 / 0 Helps hydrate Dry Skin Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

1 Com. / 0 Irr.
Tocopherol Antioxidant, Masking, Skin Conditioning
0-3 / 0-3 Vitamin E IconAntioxidant IconHelps hydrate Dry Skin IconHelps with Anti-Aging IconGood for Scar Healing IconHelps brighten skin IconMay cause irritation Icon
Vitamin EVitamin E Icon AntioxidantAntioxidant Icon 4 Benefits May cause irritationMay cause irritation Icon

Tocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.

0-3 Com. / 0-3 Irr.
Allantoin Skin Conditioning, Skin Protecting, Soothing
0 / 0 Helps reduce Skin Redness IconHelps reduce irritation IconGood for Scar Healing Icon
3 Benefits

Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.

0 Com. / 0 Irr.
Calming Relief A.I. Cream
Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Olea Europaea Fruit Oil Masking, Perfuming, Skin Conditioning
0-2 / 0 Fragrance IconOil IconNot safe for Fungal Acne Icon
FragranceFragrance Icon OilOil Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Olea Europaea Fruit Oil is the fixed oil obtained from the ripe fruit of the Olive. In other words - olive oil.

0-2 Com. / 0 Irr.
Very Disliked Full details ->
Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0 Helps hydrate Dry Skin IconHelps brighten skin Icon
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Pentylene Glycol Skin Conditioning, Solvent

Pentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.

Olus Oil Emollient
Oil IconBad for Acne Prone Skin IconNot safe for Fungal Acne Icon
OilOil Icon 2 Concerns

Olus oil is derived from vegetable oils. It is a blend of triglycerides. Triglycerides are a type of fat that circulate in your blood. The majority of Olus Oil is from rapeseed oil.

Disliked Full details ->
Elaeis Guineensis Oil Emollient
Oil IconNot safe for Fungal Acne Icon
OilOil Icon Not safe for Fungal AcneNot safe for Fungal Acne Icon

Elaeis Guineensis Oil comes from the African Palm tree. This tree is native to Western and Southwestern Africa.

Very Disliked Full details ->
Hydrogenated Lecithin Emulsifying, Skin Conditioning

Hydrogenated Lecithin is created from the hydrogenation of lecithin. Hydrogenation is a chemical reaction between molecule hydrogen and another element.

Squalane Emollient, Skin Conditioning
1 / 0 Helps hydrate Dry Skin Icon
Helps hydrate Dry SkinHelps hydrate Dry Skin Icon

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

1 Com. / 0 Irr.
Betaine Humectant, Skin Conditioning
Helps hydrate Dry Skin IconHelps reduce Skin Redness IconHelps reduce irritation Icon
3 Benefits

Betaine is a common humectant (a substance that promotes retention of moisture). It's known to be gentle on the skin and can help balance hydration.

Palmitamide Mea

We don't have a description for Palmitamide Mea.

Unknown Full details ->
Sarcosine Skin Conditioning

Sarcosine is a skin conditioning ingredient. It is a synthetic amino acid.

Acetamide Mea Humectant, Skin Conditioning

We don't have a description for Acetamide Mea.

Unknown Full details ->

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Humectant, Skin Conditioning, Skin Protecting
Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Humectant, Skin Conditioning
Loved

Betaine is a common humectant (a substance that promotes retention of moisture). It's known to be gentle on the skin and can help balance hydration.

Betaine is best for improving hydration and soothing irritated skin. Studies show betaine may help with uneven skin tones.

Betaine is naturally created in the skin and body. The form found within cosmetic products can be either plant-dervied or synthetic.

Learn more about Betaine
Emollient, Skin Conditioning
Loved

Squalane is an emollient that helps the skin hold onto moisture. It's an oily liquid that occurs naturally in certain types of fish and plant oils.

Because squalane boosts hydration in the skin, it also comes with plenty of benefits: it is an antioxidant and can help fight free radicals and skin damage. Squalane is also found to have a detoxifying effect when applied.

Squalane comes from squalene, which occurs naturally within the sebum of our skin. It is one of the oils our skin produces to keep itself hydrated. Squalane is the hydrogenated version of squalene and has a longer shelf life.

Research shows that squalane is non-irritating (even at 100% concentration).

In general, it's a fantastic ingredient. It does a great job at hydrating the skin, and it's suitable for those with sensitive skin.

The source of squalane may impact malassezia / fungal acne. This is because olive oil derived squalane can contain impurities such as fatty acids and plant waxes. Sugarcane derived squalane is recommended for anyone with malassezia concerns.

Is squalane vegan?

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Learn more about Squalane

Ingredient Ratings

Here's what our community thinks of the ingredients in these two products.

Hydrain3 Ultra-Hydrating Cream-Gel
6
liked
mixed
disliked
not rated
Calming Relief A.I. Cream
6
1
3
2
liked
mixed
disliked
not rated

When to use

4 Routines
50% use in am
50% use in pm
100% use every day
17 Routines
47% use in am
53% use in pm
100% use every day

Reviews

Here's what our community thinks

Dermedic Hydrain3 Ultra-Hydrating Cream-Gel 6 ingredients

Hydrain3 Ultra-Hydrating Cream-Gel hasn't been rated yet.
Rate it now

Physiogel Calming Relief A.I. Cream 12 ingredients

5.0 /5
from 2 ratings
DavidKoh_843's avatar

DavidKoh_843

10 months ago · Sensitive Skin
Review

does not make my eczema worse