Overview
What it is
Serum with 22 ingredients that contains azelaic acid
Cool Features
It is vegan, cruelty-free, fungal acne (malassezia) safe, and reef safe
Suited For
It has ingredients that are good for fighting acne, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, oils, parabens, silicones or sulfates
Fun facts
Regimen Lab is from Canada. This product is used in 106 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Water
Skin ConditioningAzelaic Acid
BufferingEthoxydiglycol
HumectantPotassium Azeloyl Diglycinate
Skin ConditioningButylene Glycol
HumectantGlycerin
HumectantPentylene Glycol
Skin ConditioningMethylpropanediol
SolventBetaine
HumectantAzelamidopropyl Dimethyl Amine
AntimicrobialProline
Skin ConditioningSophora Japonica Root Extract
Skin ProtectingAminoethylphosphinic Acid
Skin ConditioningAzelamide Mea
SurfactantNaringenin
Skin ConditioningTetrasodium Glutamate Diacetate
Bisabolol
AntioxidantGlucosylrutin
AntioxidantHouttuynia Cordata Extract
Skin ConditioningRutin
AntioxidantTasmannia Lanceolata Fruit/Leaf Extract
AntioxidantTetrasodium Tetracarboxymethyl Naringeninchalcone
Skin ConditioningWater, Azelaic Acid, Ethoxydiglycol, Potassium Azeloyl Diglycinate, Butylene Glycol, Glycerin, Pentylene Glycol, Methylpropanediol, Betaine, Azelamidopropyl Dimethyl Amine, Proline, Sophora Japonica Root Extract, Aminoethylphosphinic Acid, Azelamide Mea, Naringenin, Tetrasodium Glutamate Diacetate, Bisabolol, Glucosylrutin, Houttuynia Cordata Extract, Rutin, Tasmannia Lanceolata Fruit/Leaf Extract, Tetrasodium Tetracarboxymethyl Naringeninchalcone
Key Ingredients
Benefits
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterAzelaic acid is a multitasker ingredient that helps treat acne, pigmentation, and irritation. It is a great option for sensitive skin.
What makes it special?
OTC Azelaic acid is usually available in concentrations from 10-15% and anything over requires a prescription.
Here's what each tier does best:
Unlike other acids, azelaic acid will not make your skin more photosensitive/sun sensitive.
Though this ingredient is naturally occurring in grains like wheat, rye, and barley, it is usually synthetically created for cosmetics to ensure stability and effectiveness.
Learn more about Azelaic AcidEthoxydiglycol is a synthetic solvent.
Solvents are used to keep ingredients together in a product. They can help dissolve ingredients to stable bases or help evenly distribute ingredients throughout the product.
Ethoxydiglycol also helps deliver other key ingredients into the skin.
Learn more about EthoxydiglycolPotassium Azeloyl Diglycinate (PAD) comes from the condensation of azelaic acid mixed with glycine.
This ingredient has similar properties to azelaic acid; it can help reduce sebum production and soothe skin. PAD also inhibits tyrosinase activity to help brighten skin. Tyrosinase is an enzyme that controls melanin production.
A study from 2023 found 5% PAD combined with nicotinamide (a form of niacin) effectively reduced melanin production after 6 weeks.
Several studies from the 2010's also show PAD to be effective in alleviating symptoms of Rosacea.
Though this ingredient is considered a gentle active, higher amounts may result in irritation.
Unlike azelaic acid, this ingredient is water-soluble. This property makes it easier to formulate into skincare products.
Learn more about Potassium Azeloyl DiglycinateButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinPentylene glycol is typically used within a product to thicken it. It also adds a smooth, soft, and moisturizing feel to the product. It is naturally found in plants such as sugar beets.
The hydrophilic trait of Pentylene Glycol makes it a humectant. As a humectant, Pentylene Glycol helps draw moisture from the air to your skin. This can help keep your skin hydrated.
This property also makes Pentylene Glycol a great texture enhancer. It can also help thicken or stabilize a product.
Pentylene Glycol also acts as a mild preservative and helps to keep a product microbe-free.
Some people may experience mild eye and skin irritation from Pentylene Glycol. We always recommend speaking with a professional about using this ingredient in your routine.
Pentylene Glycol has a low molecular weight and is part of the 1,2-glycol family.
Learn more about Pentylene GlycolMethylpropanediol is a synthetic solvent and humectant.
As a solvent, it helps dissolve other ingredients, helping to evenly distribute ingredients throughout the product. This ingredient has also been shown to have antimicrobial properties which makes it a preservative booster.
Methylpropanediol is able to add a bit of moisture to the skin. It also helps other ingredients be better absorbed into the skin, such as salicylic acid.
Learn more about MethylpropanediolBetaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.
Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.
Some studies suggest betaine may support making skin tone more even.
Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.
Betaine is also known as trimethylglycine.
Learn more about BetaineWe don't have a description for Azelamidopropyl Dimethyl Amine yet.
Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.
It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.
Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.
Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.
Learn more about ProlineWe don't have a description for Sophora Japonica Root Extract yet.
We don't have a description for Aminoethylphosphinic Acid yet.
We don't have a description for Azelamide Mea yet.
We don't have a description for Naringenin yet.
Tetrasodium Glutamate Diacetate is a chelating agent. Chelating agents help prevent metal ions from binding to other ingredients. This helps prevent unwanted effects and reactions from a product. These metal ions may come from water and are found in miniscule amounts.
Tetrasodium Glutamate Diacetate can also help other preservatives be more effective.
Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.
It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.
A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.
In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.
You'll likely see use concentrations quite low, usually 0.1-0.2%.
Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.
Learn more about BisabololGlucosylrutin is a plant-derived antioxidant that helps neutralize reactive molecules created by UV exposure and environmental stress.
Clinical studies show its strongest benefits when used alongside broad-spectrum UVA protection. In these studies. blucosylrutin helped reduce sun-induced skin reactions such as polymorphus light eruption (sun induced rashes) and itching.
Compared to rutin, glucosylrutin is more stable and easier to formulate into water-based products (it's water soluble).
Learn more about GlucosylrutinHouttuynia Cordata Extract is more commonly known as Heart Leaf, Fish Mint, or Chameleon plant.
The components found in Heart Leaf give it antioxidant, hydrating, antimicrobial, and anti-inflammatory properties.
Heart Leaf is rich in flavonoids such as quercetin, apigenin, and more. It also contains polysaccharides, the most common type of carbs in food.
Flavonoids have been shown to be effective antioxidants. They help neutralize free-radical molecules. Free-radical molecules are unstable molecules that may damage our skin cells and DNA. The flavonoids in Heart Leaf also help soothe the skin.
Polysaccharides are naturally found in our skin. They play a role in hydrating and repairing the top layer of skin. The polysaccharides in Heart Leaf help moisturize our skin.
Studies show decanoyl acetaldehyde, a component of Heart Leaf oil, is effective at killing bacteria.
The name 'Fish Mint' comes from the herb's natural fishy smell. Is is native to southeast Asia and used throughout the continent for traditional cooking and medicine.
Learn more about Houttuynia Cordata ExtractRutin is a plant flavonoid with antioxidant and soothing properties. It helps protect skin from oxidative stress caused by UV exposure and pollution.
You'll see rutin show up in products formulated for redness prone or sensitive skin. This is because research has shown rutin to support capillaries and microcirculation.
Compared to newer derivaties like glucosylrutin, rutin is less water-soluble and stable.
Learn more about RutinTasmannia Lanceolata Fruit/Leaf Extract is an antioxidant.
We don't have a description for Tetrasodium Tetracarboxymethyl Naringeninchalcone yet.
Reviews
Average rating of all formulations of this product: 4.73
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Where it's from
Regimen Lab is a Canadian brand
Product acidity level
This product has a PH level of 4.5
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated November 21, 2025 • Added by 0xvnce