Matsuyama M-mark Amino Acid Infusion Gel
A moisturizer with 22 ingredients, including hyaluronic acid.
This barrier-repair moisturizer is formulated around Serine and Sodium PCA to strengthen the skin barrier and hydrate skin.
Worth noting
Contains drying alcohol, which absorbs quickly but can be dehydrating.
We independently verify ingredients, backed by peer-reviewed research. Suggest an update.
What's inside
Ingredients List
Water
Skin ConditioningButylene Glycol
HumectantBetaine
Humectant1,2-Hexanediol
Skin ConditioningSerine
MaskingAlanine
MaskingGlycine
BufferingThreonine
Lysine Hcl
Skin ConditioningArginine
MaskingGlutamic Acid
HumectantProline
Skin ConditioningPCA
HumectantSodium PCA
HumectantSodium Lactate
BufferingSodium Hyaluronate
HumectantPolyglutamic Acid
Skin ConditioningSorbitol
HumectantGlycosyl Trehalose
Emulsion StabilisingHydrogenated Starch Hydrolysate
HumectantAmmonium Acryloyldimethyltaurate/Vp Copolymer
T-Butyl Alcohol
PerfumingWater, Butylene Glycol, Betaine, 1,2-Hexanediol, Serine, Alanine, Glycine, Threonine, Lysine Hcl, Arginine, Glutamic Acid, Proline, PCA, Sodium PCA, Sodium Lactate, Sodium Hyaluronate, Polyglutamic Acid, Sorbitol, Glycosyl Trehalose, Hydrogenated Starch Hydrolysate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, T-Butyl Alcohol
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterButylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolBetaine is a humectant. Like hyaluronic acid, it helps attract and retain moisture in the skin. It’s known for being gentle and for helping the skin maintain balanced hydration.
Betaine is mainly used to improve hydration and support calmer skin. It helps skin cells regulate water balance because it functions as an osmolyte.
Some studies suggest betaine may support making skin tone more even.
Fun fact: Betaine naturally exists in the skin and the body. In cosmetic products, it can be either plant-derived (most commonly from sugar beets) or synthetically produced for consistency and stability.
Betaine is also known as trimethylglycine.
Learn more about Betaine1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Serine is a non-essential amino acid (your body makes it on its own!). It is a major player in your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Serine is one of your NMF's most abundant components that works as a skin-identical humectant. Its hydroxyl group grabs onto water molecules to boost hydration without any heaviness or occlusion.
Research on a hydrogel with serine confirmed this serine got delivered to your stratum corneum and demonstrated enhanced skin moisturization.
Interestingly serine also helps your skin produce filaggrin, a protein that keeps your skin barrier strong and used to create collagen.
Learn more about SerineAlanine is an amino acid and is already found in the human body. Our skin uses alanine to build collagen, elastin, and keratin.
Glycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.
Threonine is an amino-acid. It helps hydrate the skin and has antioxidant benefits.
Our skin uses threonine for creating collagen and elastin. Humans are not able to create threonine and must get it through eating foods such as fish, lentils, poultry, sesame seeds, and more.
Lysine HCl is an alpha amino acid salt.
Our skin uses amino acids as a precursor for building protein, and therefore keratins, collagen and elastin.
Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.
It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.
Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.
A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.
Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.
One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.
Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.
Learn more about ArginineGlutamic Acid is an amino acid that is found in all living organisms. Our bodies use this to help nerve cells in the brain communicate with other cells.
In cosmetics, glutamic acid is a famous humectant. It draws water from the air to your skin, keeping your skin hydrated (like hyaluronic acid).
An in-vitro study from 2024 found glutamic acid to play a role in inhibiting inflammation and thus a potential skin-soothing ingredient.
Other studies show it to be have potential wound healing, skin barrier repair, and hair growth properties.
Glutamic acid has poor solubility in water and other solvents.
Learn more about Glutamic AcidProline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.
It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.
Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.
Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.
Learn more about ProlinePCA is an amino acid derivative and one of the star players in your skin's own Natural Moisturizing Factor (NMF).
The NMF is the built-in cocktail of small molecules that keeps your outer layer of skin hydrated and your body makes it naturally.
This is why it works so well topically; PCA is a humectant that holds water in the stratum corneum and studies link higher skin PCA levels to better hydration + lower water loss. Interestingly, people show more PCA in summer and in normal vs dry skin.
Most of the benefits of this ingredient are related to hydration, softness, and barrier support.
A long-running review found that formulas with at least 2% PCA or its salts improved dry skin over both the short and long term. And the zinc salt is also used for its mild antimicrobial and astringent properties.
The salt forms are more common in cosmetics (like sodium PCA).
This ingredient is compatible with basically everything and pairs well with other humectants like glycerin or hyaluronic acid.
Usage-wise, it's typically used at low percentages (~0.2-2%).
The Cosmetic Ingredient Review Expert Panel has concluded PCA and its salts are safe as used and is non-irritating on skin even at high concentrations.
Learn more about PCASodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.
Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.
As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.
There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.
Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.
It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.
Learn more about Sodium PCASodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and sometimes used to adjust the pH of a product.
This ingredient is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin. NMF also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.
High percentages of Sodium Lactate can have an exfoliating effect.
Fun fact: Sodium Lactate is produced from fermented sugar.
Learn more about Sodium LactateSodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.
In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.
Interestingly, the size of the molecule affects its behavior:
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.
You'll typically see concentrations between 0.1-2% for this ingredient.
Learn more about Sodium HyaluronatePolyglutamic Acid is made up many glutamic acids chained together. It is created from bacterial fermentation.
This ingredient is an effective skin hydrator and may help speed up wound healing. As a humectant, it draws and holds water to the skin. This ingredient is often compared to hyaluronic acid or glycerin. Similarly to hyaluronic acid, it can vary in molecular weights. This means polyglutamic acid is capable of bringing hydration to lower levels of the skin.
Fun fact: Polyglutamic Acid is found in the Japanese food, natto. It is also being used in cancer treatment studies.
Learn more about Polyglutamic AcidSorbitol is a sugar alcohol. It is a hydrating and moisturizing agent created from the reduction process of glucose.
Most sorbitol is usually made from potato starch. It is also found in fruits such as apples and pears.
As a humectant, Sorbitol helps draw water to the skin. This helps keep the skin hydrated. Sorbitol also helps create a thicker texture in products. You might find sorbitol in your toothpaste and other gels.
It is a non-irritating ingredient that is great for those with dry skin.
Sorbitol is a prebiotic. It helps promote the growth of healthy bacteria on your skin. The bacteria on your skin form a microbiome. This microbiome helps protect your skin from infection and harmful bacteria.
Learn more about SorbitolWe don't have a description for Glycosyl Trehalose yet.
Hydrogenated Starch Hydrolysate is a made up of a mixture of sugar alcohols (like sorbitol) and is created by hydrogenating corn, wheat, or potato starch.
It acts as a humectant and draws water to the skin to keep it hydrated. Generally, this is a well-tolerated and non-irritating ingredient.
Ammonium Acryloyldimethyltaurate/Vp Copolymer is a synthetically created polymer. It's used as a film-forming agent and used to thicken the consistency of products.
Think of it as a supportive ingredient that helps your gel-creams feel silky, "cloud cream-like", and spread evenly without being greasy.
The Cosmetic Ingredient Review (CIR) Expert Panel evaluated it (along with 22 other acryloyldimethyltaurate polymers) and concluded it's:
Due to its large molecular size, it sits on the surface of skin rather than penetrating it.
Learn more about Ammonium Acryloyldimethyltaurate/Vp CopolymerT-Butyl Alcohol (aka tert-butanol) is a small, clear, camphor-smelling alcohol.
It has two main jobs:
On the safety side, it's well-studied and has a solid track record. Human repeat-insult patch testing showed no skin irritation or sensitization even at 100%.
Typical use levels are pretty tiny, usually less than 1%.
You might see some fear-mongering around this ingredient:
Studies in male rats showed kidney effects but that's because of a rat-specific protein that humans don't make. So this study isn't really relevant to humans.
Though it's not a typical fragrance like parfum, it does have a natural scent. That's why the official COSIng database lists it as 'perfuming' ingredient. It can be used to modify the scent of a formula.
Learn more about T-Butyl AlcoholReviews
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Where it's from
Matsuyama is a Japanese brand
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The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Published March 28, 2023