Complete Skin Solutions Copper Peptide Serum Versus Derma Clinicals Copper Peptide + Matrixyl 3000, Collagen, Hyaluronic Acid Serum
Updated on October 08, 2025
Overview
What they are
These products are both reef safe serums. They have a total of 7 ingredients in common
Cool Features
They both contain hyaluronic acid and peptides
Suited For
They're both likely to be good for anti aging, dry skin, brightening skin, sensitive skin, scar healing and better texture
Free From
They both do not contain any harsh alcohols, common allergens, fragrances, oils, parabens, silicones or sulfates
We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.
Ingredient Info
Complete Skin Solutions Copper Peptide Serum 11 ingredients
Derma Clinicals Copper Peptide + Matrixyl 3000, Collagen, Hyaluronic Acid Serum 15 ingredients
What's inside
What's inside
At a glance
Click on any of the items below to learn more
Complete Skin Solutions Copper Peptide Serum 11 ingredients
Derma Clinicals Copper Peptide + Matrixyl 3000, Collagen, Hyaluronic Acid Serum 15 ingredients
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Skin ConditioningSodium Hyaluronate
Humectant
Hyaluronic Acid
Humectant
Butylene Glycol
Humectant
Carbomer
Emulsion StabilisingPolysorbate 20
Emulsifying
Copper Tripeptide-1
Skin Conditioning
Palmitoyl Oligopeptide
Cleansing
Palmitoyl Tetrapeptide-7
Skin Conditioning
Collagen
Moisturising
Arthrospira Platensis Culture Conditioned Media
Antimicrobial
Panthenol
Skin Conditioning
Propylene Glycol
Humectant
Urea
Buffering
Iodopropynyl Butylcarbamate
Preservative
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Learn more about Butylene GlycolCollagen is the most abundant type of structural protein found in your body. It is an effective skin moisturizer.
There is no conclusive proof that collagen is used by skin when applied topically. However, it is a great humectant that hydrates skin. Hydrated skin is associated with increased elasticity and a decrease in the appearance of wrinkles. It is also essential for maintaining a healthy skin barrier.
Biologically, collagen is responsible for keeping skin firm and youthful. Collagen is comprised mostly of glycine, proline, and hydroxypoline. These are amino acids.
Collagen will not increase sun sensitivity, but you should always wear sunscreen during the day.
Learn more about hydrolyzed collagen here.
Learn more about CollagenCopper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.
It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.
While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.
Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.
Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.
Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.
For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.
After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.
While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.
Read more about other common types of peptides here:
Learn more about Copper Tripeptide-1Hyaluronic acid is naturally found in healthy skin. It is a humectant, meaning it draws moisture to your skin.
This ingredient helps hydrate, soothe, and protect the skin.
What makes hyaluronic acid so hydrating? It has the capacity to bind or hold large amounts of water.
Fun fact: It is already naturally found in our bodies, such as the fluids of our eyes and our joints.
Studies find this ingredient to have anti-inflammatory and anti-microbial properties. This can help speed up wound-healing.
Hyaluronic acid can be irritating if the molecule has a low-molecular weight, or if the molecules are small.
One study found low-molecular weight hyaluronic acid to be pro-inflammatory, meaning some people may experience irritation. This is because our bodies use hyaluronic acid in the wound-healing process to signal to our bodies, via irritation, that something needs healing.
The same study found high-molecular weight hyaluronic acid to be anti-inflammatory.
These are some other common types of Hyaluronic Acid:
Learn more about Hyaluronic AcidPalmitoyl Oligopeptide is a form of peptide. It is created by blending peptides with palmitic acid. Peptides are building blocks for protein.
Due to the palmitic acid base, it may not be malassezia folliculitis safe.
This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.
Read more about other common types of peptides here:
Learn more about Palmitoyl OligopeptidePalmitoyl Tetrapeptide-7 (formerly Palmitoyl Tetrapeptide-3) is a lab-made peptide with anti-inflammatory and skin-repairing benefits. It's made up of four amino acids (glycine, glutamine, proline, and arginine) and palmitic acid (which helps it penetrate skin more effectively).
This ingredient helps reduce inflammation by limiting the production of interleukin-6 (IL-6), a chemical that triggers inflammatory responses, particularly after UV exposure.
Less inflammation = slower collagen breakdown and a longer-lasting, youthful appearance.
Palmitoyl Tetrapeptide-7 also stimulates collagen production and supports a healthier skin barrier.
Over time, this can improve skin firmness, hydration, and reduce the appearance of fine lines. It’s commonly paired with Palmitoyl Tripeptide-1 in the well-known Matrixyl 3000 complex for enhanced anti-aging effects.
This ingredient has been shown to be effective and safe in cosmetic use and you'll typically find it in small amounts (less than 0.01%).
Due to its palmitic acid base, it may not be safe for Malassezia folliculitis.
Read more about other common types of peptides here:
Learn more about Palmitoyl Tetrapeptide-7Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterIngredient Ratings
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