Is Clinical Poly-Vitamin Serum
A serum with 15 ingredients, including retinoid, niacinamide, and vitamin E.
Overview
What it is
Serum with 15 ingredients that contains hyaluronic acid, niacinamide, retinoid and Vitamin E
Cool Features
It is reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, parabens, silicones or sulfates
Fun facts
Is Clinical is from United States.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Water
Skin ConditioningSodium Hyaluronate
HumectantNiacinamide
SmoothingSaccharum Officinarum Extract
MoisturisingZinc Sulfate
AntimicrobialPantothenic Acid
Skin ConditioningVaccinium Myrtillus Fruit/Leaf Extract
AstringentLysine
Skin ConditioningGlutamine
Skin ConditioningPEG-60 Hydrogenated Castor Oil
EmulsifyingPolysorbate 20
EmulsifyingCamellia Sinensis Leaf Extract
AntimicrobialTocopherol
AntioxidantRetinol
Skin ConditioningPhenoxyethanol
PreservativeKey Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterSodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.
Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.
Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.
These are some other common types of Hyaluronic Acid:
Learn more about Sodium HyaluronateNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideThis ingredient is also called sugarcane extract. It is a moisturizing humectant and has skin soothing properties.
Similar to hyaluronic acid, sugarcane can attract moisture to your skin.
Glycolic acid is a derivative of sugarcane. While glycolic acid is an AHA with exfoliating properties, sugarcane is not an AHA.
A study from 2021 found the compounds in sugarcane extract to have antioxidant, antimicrobial, and anti-inflammatory activity. The study also suggests these compounds can inhibit skin ageing enzymes and promote collagen synthesis.
Learn more about Saccharum Officinarum ExtractZinc Sulfate has antimicrobial and astringent properties. It is created synthetically from zinc and sulfuric acid.
Despite having ‘sulfate’ in the name, it isn’t a surfactant or cleansing agent like sodium lauryl sulfate. Unlike those sulfates, zinc sulfate doesn’t have the same cleansing or foaming properties.
Pantothenic Acid is an essential vitamin. Our bodies use it for metabolizing fatty acids, proteins, carbohydrates, and fats.
We don't have a description for Vaccinium Myrtillus Fruit/Leaf Extract yet.
Lysine is an essential amino acid. Your body is unable to produce it naturally and we mainly get lysine from food sources.
Our bodies use lysine for growth and tissue repair. The skin uses amino acids as a precursor for building protein, and therefore keratins, collagen and elastin.
We don't have a description for Glutamine yet.
Peg-60 Hydrogenated Castor Oil comes from hydrogenated castor oil. It is a solubilizer and emulsifier.
As a solubilizer, it helps dissolve ingredients into a water-based version. It is also an emulsifer. Emulsifier help prevent oils and water from separating. Both these properties help create evenly-spread and uniform products.
Basically, Peg-60 Hydrogenated Castor Oil helps hold ingredients together.
Learn more about PEG-60 Hydrogenated Castor OilPolysorbate 20 is made by combining ethoxylation of sorbitan, ethylene oxide, and lauric acid. It is a mild cleansing agent, surfactant, and emulsifier.
As a surfactant, it helps collect dirt and oils for washing. Emulsifiers prevent oils and water from separating.
Polysorbate 20 also adds scent to a product. Since it is made using sorbitol, it has a sweet scent. Sorbitol can also be found in fruits such as apples and peaches.
The lauric acid used to create Polysorbate 20 is often derived from coconuts.
Polysorbate 20 may not be fungal acne safe.
Learn more about Polysorbate 20Camellia Sinensis Leaf Extract is derived from the leaves of the tea plant. Black tea, green tea, and oolong tea are all harvested from this plant.
This ingredient has many skin benefits:
This ingredient contains polyphenols, a strong antioxidant. Antioxidants help fight off molecules that damage skin cells.
On top of that, the antioxidants in green tea neutralize free-radicals from the sun. This gives the skin some extra UV protection, but should not replace sunscreen.
Many components of tea have anti-inflammatory properties.
Polyphenols and L-theanine help soothe the skin and reduce irritation. The caffeine in Camellia Sinensis Leaf Extract helps calm inflamed blood vessels.
Other compounds found in tea include: Vitamin Bs, linoleic acid, magnesium, calcium, iron, and zinc.
Research has shown both drinking Camellia Sinensis Leaf Tea and applying it to the skin can help boost skin elasticity and hydration. Studies also show using tea extract may reduce sebum, or oil, production.
Learn more about Camellia Sinensis Leaf ExtractTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolRetinol is a gold-standard ingredient for anti-aging. It is a form of Vitamin A and belongs to the class of retinoids that also includes tretinoin.
Why is retinol famous?
It has the most scientific studies backing up its skin benefits out of all the non-prescription ingredients.
Retinol is proven to:
This is why retinol is effective at removing wrinkles, fading dark spots, treating acne, and reducing the appearance of pores.
Studies show retinol is less effective when exposed to UV. Be sure to look for appropriate packaging to keep your retinol potent (similar to Vitamin C).
Using retinol or any retinoids will increase sun-sensitivity in the first few months. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.
We recommend speaking with a medical professional about using this ingredient during pregnancy.
Retinol may cause irritation in some people, so be sure to patch test. Experts recommend 'ramping up' retinol use: start using this ingredient once a week and work up to using it daily.
Read about Tretinoin
Learn more about RetinolPhenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent microbial growth. By itself, it has a scent that is similar to that of a rose.
It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.
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Where it's from
Is Clinical is a American brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated October 21, 2025 • Added by Suzamazen