Overview
What it is
Serum with 11 ingredients that contains bakuchiol and Vitamin E
Cool Features
It is vegan, cruelty-free, and reef safe
Suited For
It has ingredients that are good for anti aging, dry skin, brightening skin, sensitive skin, oily skin, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, parabens, silicones or sulfates
Fun facts
4.5.6 is from France.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Explained
We don't have a description for Heptyl Undecylenate yet.
This ingredient is a solvent, texture enhancer, and emollient.
Solvents help other ingredients dissolve in a product. It adds a 'silky' texture to products and is thus considered a silicone alternative.
This ingredient feeds fungal-acne due to its 13-16 carbon chain.
Learn more about C13-16 IsoparaffinCannabis Sativa Seed Oil is the fixed oil expressed from the seeds of the Cannabis sativa plant. This is also known as hemp oil.
Hemp oil is an emollient and nourishes the skin. It contains many fatty acids such as linoleic acid, amino acids, phospholipids, and vitamin E.
The difference between hemp and cannabis is their psychoactive component. Hemp has low amounts of THC.
Learn more about Cannabis Sativa Seed OilThis ingredient is also known as olive oil. It has been used in skincare for centuries and science largely backs up its reputation as a nourishing emollient.
The main components of olive oil are oleic acid (55-83%), linoleic acid (3.5-20%), and palmitic acid (7-20%). Oleic acid promotes skin regeneration and helps regulate inflammatory responses.
Squalene is also naturally present in olive oil and exhibits moisturizing and antioxidant properties.
The polyphenols in olive oil also show anti-aging promise; one clinical study found a measurable improvement in skin appearance after 30 days of topical serum use.
Just be aware that applying olive oil directly to skin can weaken the barrier and cause redness. One study with volunteers found even people without sensitive skin experienced a significant reduction in stratum corneum integrity and induced mild erythema.
It's best to use this ingredient as part of a carefully crafted formula (instead of putting it on skin directly from the bottle).
Because it has a 2-3 on the comedogenic scale, it is a moderate risk for acne-prone skin. However, the overall formulation of a product matters more than a few ingredients with comedogenic ratings.
This ingredient may not be fungal acne safe because of the oleic and palmitic acid content. These fall within the C11-24 fatty acid range that the Malassezia yeast can metabolize to grow.
Overall, olive oil is a well-studied and nourishing skincare ingredient.
Learn more about Olea Europaea Fruit OilThis ingredient is also known as black seed oil or black cumin. It has emollient, skin conditioning, and perfuming properties.
It is rich in linoleic and oleic acids, making it a great skin hydrator or emollient. Other compounds found in black seed oil include thymoquinone, sterols, and various terpenes; these compounds give it antioxidant, anti-inflammatory, and antimicrobial properties.
Studies show thymoquinone helps reduce oxidative stress and dampens the inflammatory pathways. Combining this with the oils makes this ingredient great for barrier repair and moisturization.
Other studies have found this ingredient to have antimicrobial activity against several acne-causing bacteria.
Learn more about Nigella Sativa Seed OilAnother popular name for this ingredient is Synovea HR. This ingredient is a skin lightener and antioxidant.
Like other skin lighteners, it blocks the process of skin darkening. Specifically, this ingredient blocks tyrosinase, the enzyme responsible for darkening skin when exposed to UV.
Hexylresorcinol works well with other ingredients. Studies show this ingredient boosts the effect of niacinamide, various forms of vitamin C, and retinoids.
Many consider this to be a safer alternative to hydroquinone. In fact, this ingredient produces the same results as hydroquinone in lower amounts.
Fun fact: This ingredient can also be found food and medicine for treating skin infections.
Gentle reminder from SkinSort: all skin tones are beautiful!
Learn more about HexylresorcinolBakuchiol is a plant-derived antioxidant from the seeds of the Psoralea corylifolia plant. It has antimicrobial, emollient, skin conditioning, and antioxidant properties.
You'll likely see it called a "retinol replacement" but the two are technically not related. This is because bakuchiol is able to flip many of the same switches in your skin cells to tell them to:
1) produce more collagen (type I, III, and IV)
2) activate the same genes retinoids do
Unlike retinoids, this ingredient will not increase photosensitivity and is safe to use during pregnancy (but please still check in with your doctor!).
The flagship clinical trial from Dhaliwal et al. 2019 found 0.5% bakuchiol (twice daily) and 0.5% retinol (once daily) reduced wrinkles and hyperpigmentation equally, but bakuchiol had significantly less irritation.
Systematic reviews also back this up:
Bakuchiol is comparable to retinol for photoaging but with better tolerability. It also has mild antibacterial properties against Cutibacterium acnes and antifungal activity in vitro against Candida and dermatophytes.
The reason bakuchiol works well is due to its structure; it is a meroterpene phenol, or a hybrid molecule. The phenol half acts as an antioxidant while the terpene half is fat-loving. This helps the molecule slip through the skin barrier.
This ingredient is usually used between 0.5-2%. Only one case of contact dermatitis has ever been reported for this ingredient.
Learn more about BakuchiolTocopherol (also known as Vitamin E) is a common antioxidant used to help protect the skin from free-radicals and strengthen the skin barrier. It's also fat soluble - this means our skin is great at absorbing it.
Vitamin E also helps keep your natural skin lipids healthy. Your lipid skin barrier naturally consists of lipids, ceramides, and fatty acids. Vitamin E offers extra protection for your skin’s lipid barrier, keeping your skin healthy and nourished.
Another benefit is a bit of UV protection. Vitamin E helps reduce the damage caused by UVB rays. (It should not replace your sunscreen). Combining it with Vitamin C can decrease sunburned cells and hyperpigmentation after UV exposure.
You might have noticed Vitamin E + C often paired together. This is because it is great at stabilizing Vitamin C. Using the two together helps increase the effectiveness of both ingredients.
There are often claims that Vitamin E can reduce/prevent scarring, but these claims haven't been confirmed by scientific research.
Learn more about TocopherolUbiquinone (Coenzyme Q10) is a molecule already found in our bodies. It is a potent antioxidant and skin-soothing ingredient.
Aging and environmental exposure diminishes our skin's natural ubiquinone levels. This is much like our natural collagen and elastin.
The good news is: studies show applying this ingredient topically replenishes ubiquinone levels in our skin. This also comes with a ton of skin benefits. These benefits include:
Ubiquinone is considered a large molecule and cannot be absorbed into the lower layers of skin. This is why it is believed to be such an effective antioxidant: it protects our skin in the upper layers and prevents damage in the deeper layers.
When used in sunscreen, ubiquinone is shown to increase ingredient stability, increase SPF factor, and add to infrared protection.
Fun fact: ubiquinone is fat-soluble.
Learn more about UbiquinoneMelia Azadirachta Seed Oil is an oil and isn't fungal acne safe.
Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.
Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.
For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.
The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.
For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.
One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.
Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.
Parfum can also be used to mask or cover an unpleasant scent.
The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.
Learn more about ParfumReviews
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Where it's from
4.5.6 is a French brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated February 4, 2025 • Added by jnm