Versus

Differin Adapalene Gel 0.1% Acne Treatment Versus Galderma Epiduo

Facial Treatment
Prescription
American Brand United States
Swiss Brand Switzerland

Updated on July 05, 2025

Overview

Cool Features

They both contain retinoid

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, oily skin, reducing pores, scar healing and better texture

Free From

They both do not contain any harsh alcohols, common allergens, fragrances, oils, silicones or sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

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What's inside

What's inside

At a glance

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Key Ingredients

Benefits

Concerns

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA
Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water

Adapalene is a third-generation topical retinoid and is best known for treating mild to moderate acne. It’s also commonly as for its brand name, Differin.

Adapalene has some great benefits:

You can buy over-the-counter adapalene at 0.1% gel strength. Higher concentrations require a prescription.

Oleyl adapalenate is a cosmetic-grade derivative of adapalene that does not require a prescription since it is considered a cosmetic ingredient.

Learn more about Adapalene

When to use

4,184 Routines
8% use in am
92% use in pm
68% use every day
When to use See routines that use it ->
420 Routines
4% use in am
95% use in pm
75% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

4.51
Overall rating
5
4
3
2
1
What people say
Works Well 54% Absorbs Well 51% No Scent 51%

Galderma Epiduo 12 ingredients

3.75
Overall rating
5
4
3
2
1
What people say
Works Well 67% Absorbs Well 50% Irritating 33%