The Agency Eye Formula
A prescription with 11 ingredients, including retinoid and vitamin E.
Prescription with 11 ingredients that contains retinoid and Vitamin E
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What's inside
Ingredients List
Tretinoin 0.002%
Skin ConditioningPanthenol 1%
Skin ConditioningEpigallocatechin Gallate 2%
AntioxidantCaffeine 1%
Skin ConditioningCamellia Sinensis Leaf Extract
Antimicrobial
Active Ingredients:
Tretinoin 0.002%, Panthenol 1%, Epigallocatechin Gallate 2%, Caffeine 1%
Inactive Ingredients:
Camellia Sinensis Leaf Extract, Olus Oil, C30-45 Alkyl Methicone, C30-45 Olefin, Cetearyl Olivate, Cera Alba, Tocopheryl Acetate
Key Ingredients
Benefits
Concerns
Ingredients Explained
Tretinoin (aka retinoic acid) is the gold standard retinoid in dermatology because it's the form of vitamin A that your skin can use right away. It's a prescription drug and regulated as medication in most countries.
Unlike retinol, it skips the conversion steps and goes straight to work.
Inside your skin cells, it binds to receptors called retinoic acid receptors and switches on the genes that control how skin cells behave.
For acne, it helps your skin shed dead cells properly instead of letting them build up and clog your pores (this is what turns into blackheads and pimples). It also calms redness/swelling, which is why it's a FDA-approved acne treatment.
Tretinoin also tells your skin to make more collagen and slows down the stuff that breaks collagen apart too. Over time, your skin looks smoother, softer, and more even, with fewer lines lines and sun spots.
The evidence for this ingredient is strong:
A systematic review of randomized controlled trials found that topical tretinoin consistently improved wrinkles, pigmentation, sallowness, and dark spots. Results typically showed up as early as one month and lasted out to 24 months.
All studies also found this ingredient to be safe and well-tolerated.
Typical concentrations run from about 0.01-0.1%, with 0.025%-0.1% being the usual range studied for photoaging and a 0.05% cream producing measurable wrinkle/roughness improvements in large six-month trials.
The main trade-off is irritation; dryness, peeling, redness, and sun sensitivity are common in the first few weeks so be sure to pair it well with a good moisturizer and daily sunscreen.
Learn about a form of retinoid you can purchase at the store, retinol.
Learn more about TretinoinPanthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.
There are two forms of panthenol: D and L.
D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.
Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):
Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.
This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.
Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.
This ingredient is also referred to as pro-vitamin B5.
Learn more about PanthenolEpigallocatechin Gallate (EGCG) is the most abundant catechin in green tea. It is a heavyweight antioxidant in the green tea family.
In skincare, it helps protect skin from photoaging damage by scavenging UV-induced reactive oxygen species and tampering down inflammatory pathways.
UV-exposed skin cells treated with EGCG showed less of the enzyme that chews up collagen, lower inflammatory signaling, and better preserved barrier function.
EGCG nudges skin cells to make more of your skin's built in moisturizing molecules, filaggrin and hyaluronic acid, for better skin hydration.
Because it inhibits melanogenesis, it also provides a mild brightening effect.
Clinically, topical EGCG has helped calm radiation-related skin irritation and scalp seborrheic dermatitis with no major side effects.
In an 8-week split-face study, topical EGCG at 1% and 5% significantly reduced inflammatory and non-inflammatory acne.
A study from 2023 on patients with Seborrhea (a chronic skin condition caused by overactive sebaceous glands) found that using a 5% EGCG cream (alone and combined with 2% L-carnitine) and found meaningful sebum reduction plus better hydration.
Just one caveat here: Most clinical trials used 1-5% concentrations and most cosmetics contain only 0.1-1%.
The only headache related to this ingredient is stability. EGCG degrades quickly with heat, light, oxygen, and higher pH.
That's why you'll usually see it in low-pH formulas (4.5-6.5) or paired with vitamin C + vitamin E to slow its degradation. Hyaluronic acid also stabilizes it and boosts its antioxidant activity.
Learn more about Epigallocatechin GallateCamellia Sinensis Leaf Extract (tea extract) is one of the most well-researched plant extracts in skincare with an impressive resume.
Black tea, green tea, and oolong tea are all harvested from the Camellia Sinensis plant.
Studies show green tea extract and its catechins (like epigallocatechin gallate (EGCG)) help your skin cells product energy more efficiently and reducing the number of free-radicals that can damage your skin from the inside.
In lab-grown skin models, this translated to younger, healthier, and stronger skin.
There's also good sun protection data; researchers saw less DNA damage and redness on human skin when green tea was applied before UVB exposure. And the more they applied, the better the protection.
Needless to say, this ingredient shouldn't replace your sunscreen. But it is a great supportive ingredient that you can already find in many sunscreens and antioxidant serums.
A 2009 study found a 2% green tea lotion was effective for mild-to-moderate acne thanks to its anti-inflammatory and mild antimicrobial activity.
The quality of the extract matters a lot here:
Good extracts contain 50-90% catechins while lower quality ones are mostly there for marketing. We recommend reaching out to the brand if you have questions about the quality or source of their ingredients.
Human Repeated Insult Patch Testing showed no irritation or sensitization at use concentrations (0.86% in leave-on products and up to 30% as leaf water).
Learn more about Camellia Sinensis Leaf ExtractCaffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
Learn more about CaffeineOlus Oil is the INCI umbrella name for vegetable oil; this is an oil of plant origin made up mostly of fatty acid triglycerides.
The key thing to know is that it's a generic term rather than one specific oil: it refers to a vegetable oil or a blend of vegetable oils so its effect may vary depending on the sources used.
Functionally, it's an emollient that helps soften skin and works as a hydrator to prevent water loss.
This ingredient works well across a wide pH range and has a long shelf life.
Fungal acne:
Because olus oil is an undefined blend, its fungal acne safety depends entirely which oils are used. A Caprylic/Capric Triglyceride-based version would be fungal acne safe while a rapeseed blend will contain longer-chain fatty acids that Malassezia can feed on.
C30-45 Alkyl Methicone is a type of silicone.
We don't have a description for C30-45 Olefin yet.
Cetearyl Olivate is a plant-derived emulsifier and texture enhancer. It helps keep the oil and water phases from separating so your formulas stay stable.
You'll likely see it combined with Sorbitan Olivate (together sold as the trade name Olivem 1000). This combination generates a liquid crystal structure that closely resemble the lipid organization of the stratum corneum.
These "skin-like" liquid crystals improve skin barrier integrity and promote the delivery of actives into the skin.
This ingredient is well-tolerated and has no significant sensitization data.
Because it is derived from the fatty acids in olive oil, this ingredient may not be fungal acne safe.
Learn more about Cetearyl OlivateCera alba is beeswax, or the wax used by bees to make honeycombs. It is a texture-enhancer and emollient. A study from 2003 found beeswax to be a stronger emollient than ingredients such as petroleum jelly.
As an emollient, beeswax helps hydrate the skin by creating a barrier on top. This barrier traps moisture in.
Emulsifiers help prevent ingredients from separating. This helps create consistent texture.
The structure of beeswax is mainly long-chain alcohols and the esters of fatty acids.
There are three types of beeswax: yellow, white, and absolute. Yellow is pure beeswax taken from the honeycomb. White beeswax is created by filtering or bleaching yellow beeswax. Absolute beeswax is created by treating beeswax with alcohol. Beeswax used in cosmetics are purified.
Beeswax has been used throughout history and even in prehistoric times. Some common uses for beeswax still used today are making candles, as a waterproofing agent, and polish for leather.
Beeswax's wax esters are derived primarily from palmitic and oleic acid (C16 and C18:1). Both of these fall within the C11-C24 feeding window.
The Malassezia yeast can potentially cleave these esters and release usable fatty acids, so this ingredient may not be fungal acne safe. However, not everyone will react to this ingredient.
Learn more about Cera AlbaTocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Learn more about Tocopheryl AcetateReviews
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The Agency is a American brand
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Read more about us· Updated September 16, 2025 • Added by aliboo