Galderma Epiduo Gel 0.1%/2.5%
A highly rated prescription with 15 ingredients, including retinoid and benzoyl peroxide.
Overview
What it is
Prescription with 15 ingredients that contains benzoyl peroxide and retinoid
Cool Features
It is reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, oily skin, reducing pores, scar healing and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, oils, parabens, silicones or sulfates
Fun facts
Galderma is from Switzerland. This product is used in 659 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Adapalene 0.1%
Benzoyl Peroxide 2.5%
Hydrogen Peroxide
AntimicrobialDiethylhexyl Sodium Sulfosuccinate
CleansingDisodium EDTA
Glycerin
Humectant
Poloxamer 407
EmulsifyingPropylene Glycol
Humectant
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer
Emulsion StabilisingIsohexadecane
EmollientPolysorbate 80
Emulsifying
Acrylamides Copolymer
Sodium Acryloyldimethyltaurate Crosspolymer
Emulsion StabilisingSorbitan Oleate
Emulsifying
Water
Skin Conditioning
Active Ingredients:
Adapalene 0.1%, Benzoyl Peroxide 2.5%
Inactive Ingredients:
Hydrogen Peroxide, Diethylhexyl Sodium Sulfosuccinate, Disodium EDTA, Glycerin, Poloxamer 407, Propylene Glycol, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Isohexadecane, Polysorbate 80, Acrylamides Copolymer, Sodium Acryloyldimethyltaurate Crosspolymer, Sorbitan Oleate, Water
Key Ingredients
Benefits
Concerns
Ingredients Explained
Adapalene is a third-generation topical retinoid and is best known for treating mild to moderate acne. It’s also commonly as for its brand name, Differin.
Adapalene has some great benefits:
You can buy over-the-counter adapalene at 0.1% gel strength. Higher concentrations require a prescription.
Oleyl adapalenate is a cosmetic-grade derivative of adapalene that does not require a prescription since it is considered a cosmetic ingredient.
Learn more about AdapaleneBenzoyl Peroxide (BPO) is one of the most studied and widely used acne-fighting ingredients on the market for over five decades.
It works by releasing oxygen into your pores to kill Cutibacterium acne, or the bacteria closely linked to acne breakouts. This bacteria has a hard time surviving in an oxygen-rich environment.
On top of that, BPO has keratolytic properties to help shed dead skin cells and keep pores from getting clogged.
One of the coolest things about BPO is that bacteria do not develop resistance to it the way they can with antibiotics. That's why dermatologists recommend pairing it with topical antibiotics to keep resistance at bay.
BPO is usually available in 2.5%, 5%, and 10% concentrations. Research has shown that 2.5% tends to be just as effective as the higher strengths while being more gentle on the skin.
The FDA has classified BPO as a safe and effective acne treatment. You'll be able to find this ingredient in over-the-counter products in many countries.
Just so you know, BPO is a known mild irritant. It's common to see dryness, peeling, and some redness when you first start using it. This usually goes away as your skin adjusts.
A very small number of people might develop allergic contact dermatitis from it as patch test studies show positive reactions in about 1-5% of patients.
Once BPO is absorbed into the skin, our bodies turn it into benzoic acid and quickly exits in urine. It's also worth noting that BPO will bleach fabrics and hair, so watch your towels and pillowcases!
Learn more about Benzoyl PeroxideWe don't have a description for Hydrogen Peroxide yet.
This ingredient is also known as docusate sodium.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Learn more about Disodium EDTAGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinWe don't have a description for Poloxamer 407 yet.
Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.
As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.
The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.
True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).
It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.
Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.
Learn more about Propylene GlycolThis ingredient is a synthetic polymer used to stabilize formulas and give products a "gel-cream" feel.
When applied, this ingredient mostly stays on the surface of skin. Safety reviews have found these polymers safe in cosmetics when made to proper quality standards. Testing also shows they’re unlikely to cause irritation or sensitization at normal use levels.
Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.
Due to its large size, Isohexadecane is not absorbed by the skin. Instead, it sits on top and acts as an emollient. Emollients help keep your skin soft and smooth by trapping moisture within.
Isohexadecane is often used in products designed to help oily skin. It is lightweight and non-greasy while helping to moisturize. When mixed with silicones, it gives a product a silky feel.
Learn more about IsohexadecanePolysorbate 80 is a surfactant and emulsifier. It is used to keep ingredients together, and prevent oils and waters from separating.
It is made from polyethoxylated sorbitan and oleic acid. This ingredient can be found in cosmetics, foods, and medicine. It is water-soluble.
Polysorbate 80 may not be fungal acne safe.
Learn more about Polysorbate 80We don't have a description for Acrylamides Copolymer yet.
We don't have a description for Sodium Acryloyldimethyltaurate Crosspolymer yet.
Sorbitan Oleate is created from compounds in oleic acid and sorbitol.
It is used to stabilize a product by preventing ingredients from separating. Emulsifiers help keep ingredients together, such as oils and water.
According to a manufacturer, the ingredient Sorbitan Monooleate shares an INCI name with this one.
Sorbitan Oleate may not be fungal acne safe. It can also worsen oily skin.
Learn more about Sorbitan OleateWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterReviews
Where it's from
Galderma is a Swiss brand
Often compared with
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated January 12, 2026 • Added by lingoflamingo
