Orion Pharma Avitcid 0.05 % Emulsion Cream
A prescription with 10 ingredients, including retinoid and vitamin E.
Prescription with 10 ingredients that contains retinoid and Vitamin E
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Key Ingredients
Benefits
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Ingredients Explained
Tretinoin (aka retinoic acid) is the gold standard retinoid in dermatology because it's the form of vitamin A that your skin can use right away. It's a prescription drug and regulated as medication in most countries.
Unlike retinol, it skips the conversion steps and goes straight to work.
Inside your skin cells, it binds to receptors called retinoic acid receptors and switches on the genes that control how skin cells behave.
For acne, it helps your skin shed dead cells properly instead of letting them build up and clog your pores (this is what turns into blackheads and pimples). It also calms redness/swelling, which is why it's a FDA-approved acne treatment.
Tretinoin also tells your skin to make more collagen and slows down the stuff that breaks collagen apart too. Over time, your skin looks smoother, softer, and more even, with fewer lines lines and sun spots.
The evidence for this ingredient is strong:
A systematic review of randomized controlled trials found that topical tretinoin consistently improved wrinkles, pigmentation, sallowness, and dark spots. Results typically showed up as early as one month and lasted out to 24 months.
All studies also found this ingredient to be safe and well-tolerated.
Typical concentrations run from about 0.01-0.1%, with 0.025%-0.1% being the usual range studied for photoaging and a 0.05% cream producing measurable wrinkle/roughness improvements in large six-month trials.
The main trade-off is irritation; dryness, peeling, redness, and sun sensitivity are common in the first few weeks so be sure to pair it well with a good moisturizer and daily sunscreen.
Learn about a form of retinoid you can purchase at the store, retinol.
Learn more about TretinoinTocopheryl Acetate is a stable, shelf-friendly form of vitamin E.
Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.
It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.
One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.
Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.
Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.
This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.
The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.
Most leave-on skincare keeps it at the lower end, often between 0.5-1%.
Learn more about Tocopheryl AcetateCetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.
Its main roles are:
Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Learn more about Cetyl AlcoholStearyl Alcohol is a type of fatty alcohol from stearic acid. It is a white, waxy compound used to emulsify ingredients used as an emollient or to thicken a product.
Emollients help soothe and hydrate the skin by trapping moisture.
Fatty alcohols are usually derived from natural fats and oils and therefore do not have the same drying or irritating effect as solvent (ethanol) alcohols.
The FDA allows products labeled "alcohol-free" to have fatty alcohols.
This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.
Learn more about Stearyl AlcoholCetyl Palmitate is a wax-ester that pulls triple duty as an emollient, thickener, and emulsion enhancer.
It helps enhance the texture of products by giving a smooth, silky feel while helping to stabilize the formula. The emollient action softens skin and reduces moisture loss.
This ingredient is considered safe and human testing of concentrations between 2.5-2.7% were found minimal irritation. Just know, there have been very rare cases of the palmitate family causing contact dermatitis.
This ingredient may not be fungal acne safe because it contains a C16 ester (palmitic acid) that falls into the C11-24 range that Malassezia can feed on.
Learn more about Cetyl PalmitatePropylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.
As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.
The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.
True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).
It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.
Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.
Learn more about Propylene GlycolSodium Lauryl Sulfate (SLS) is a surfactant, cleansing agent, and foaming agent. You'll find it in a wide range of products from shampoos to face cleansers.
It:
The Cosmetic Ingredient Review Panel has assessed it in 1983, 2002, and 2005 and found it to be safe in formulations at low concentrations.
SLS is a well-documented skin irritant at higher concentrations or with prolonged exposure. It's actually the gold standard positive control used in dermatological patch testing, meaning doctors use it because they know it will cause a reaction in people.
In one large study of 43,000 patiences tested with 0.25% SLS, about 22% showed some level of reactivity. It increases transepidermal water loss that disrupts your outermost layer of skin.
Face cleansers often pair this ingredient with mild co-surfactants like Cocamidopropyl Betaine to buffer its harshness.
Just so you know, SLS does not trigger true allergic contact dermatitis. This just means it can irritate your skin but doesn't cause your immune system to develop a lasting allergy to it.
Despite internet rumors, SLS is not considered a carcinogen by any major regulatory body.
Learn more about Sodium Lauryl SulfateMethylparaben is a synthetic preservative and one of the most widely used in the world. It has a simple, but important job: prevent your products from going bad by stopping bacteria, yeast, and mold from growing.
Typical use levels are low, often 0.1-0.3%.
This is also one of the most heavily studied preservatives out there and major regulatory bodies have repeatedly given it the green light.
In 2023, the EU's Scientific Committee on Consumer Safety (SCCS) confirmed that this ingredient is safe up to 0.4% on its own, of up to 0.8% when mixed with other paraben esters.
Here's the science behind the noise behind parabens/hormones as well:
Methylparaben shows very weak estrogen-like activity in vitro tests (more than 1,000x weaker than your body's own estradiol). In vivo (live-organism) studies don't support a meaningful endocrine-disrupting effect either.
You get a stronger estrogenic effect from eating tofu, actually.
It's also a low sensitizer and allergic reactions are uncommon; they usually happen on damage or broken skin.
There is a caveat: France has proposed to formally re-examine its endocrine classification in 2025 so the regulatory conversation isn't fully closed as of yet.
But as it stands today, this ingredient is considered safe at permitted levels.
Learn more about MethylparabenPropylparaben is a preservative and one of the most widely used members of the paraben family (it's been used in cosmetics for over a century now).
It works by disrupting microbial cell membranes and enzymes, and is a broad-spectrum protector that works exceptionally well against molds, yeasts, and gram-positive bacteria.
You'll likely see it paired with methylparaben to cover the full range (including gram-negative bacteria).
This ingredient is effective at low concentrations (~0.2-0.5%) and stable across a wide pH range (4.5-7.5 pH). It's effectiveness drops off above pH 8 and it can lose potency when combined with non-ionic surfactants like polysorbate 80 due to micellization.
The regulatory bodies have concluded this ingredient to be safe as used in cosmetics. The EU has capped it at 0.14% and combined parabens are not to exceed 0.8%.
While parabens do cross the stratum corneum, only about 1% remains for absorption into the body. This is because most of it is metabolized within living skin.
Learn more about PropylparabenWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterReviews
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Where it's from
Orion Pharma is a Finnish brand
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