Meko Waterproof Liquid Eyeliner

The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.

True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).

It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.

Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.

Like other types of silica, this ingredient can be used to thicken a product. As an absorbent, it may be used to absorb extra water or help prevent clumping.

Although “aluminum” in an ingredient name can raise red flags for some consumers, the form and usage context matter significantly. For typical topical applications, there is no substantial evidence of health risks - such as cancer, neurotoxicity, or systemic “aluminum overload.”

It is less effective in high-humidity. It tends to draw moisture, but this moisture dismantles the structure and "hold".

PVP is generally well tolerated on skin and toxicity studies are negative for dermal irritation.

PH adjusters are common in cosmetic products. The pH of a product can affect the effectiveness of other ingredients. A product with a high pH may also irritate the skin.

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In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Because it is not a free-fatty acid or alcohol, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

It is typically used at very low levels in cosmetics, with most formulations using 0.0125% or less (well below its approved maximum).

In the EU, IPBC concentration limits are set at 0.02% in rinse-off products and 0.01% in leave-on products.

Though IPBC is a relatively uncommon contact allergen, patch testing studies show positive reaction rates ranging from 0.3%-0.9% of patients tested. This is still quite low compared to preservatives like methylisothiazolinone which sits at around 4-5%.

Researchers note that existing iodine sensitives or rubber allergies may be the cause of this as IPBC shares a structure with both thiuram (used in rubber) and iodine.

Be sure to patch test if you are unsure and speak with a medical professional about using this ingredient.

Synthetically created Ci 77491 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

In the US, this ingredient can only be used if it meets strict FDA specifications. Certain versions even require batch-by-batch certification after extensive safety evaluation.

In the European Union, this ingredient is permitted as a colorant and classified as a "nanomaterial" based on its particle size (meaning it requires deeper assessment).

The EU Scientific Committee on Consumer Safety (SCCS) has reviewed nano-sized carbon black specifically and concluded that it does not pose a risk to human health when used in cosmetic products applied to healthy, intact skin and formulated to avoid inhalation.

Studies support this regulatory stance. Laboratory studies on nano-carbon black show potential for cytotoxicity and inflammatory effects in immune cells; it is important to highlight these findings are based on in vitro (not done on a living organism) testing or inhalation scenarios rather than normal topical cosmetic use.

Occupational studies involving industrial workers exposed to airborne carbon black have not shown a clear link between cumulative exposure and cancer risk. These findings are not directly applicable to cosmetics; cosmetic formulations bind pigments within creams, gels, and liquids that are not inhaled.

Overall, evidence shows that this ingredient is safe under regulatory guidelines and purity standards, especially when formulated to avoid airborne exposure.

Even with regulatory approval and a long history of use, some consumers might prefer to avoid ingredients that are petroleum-derived or that fall under the “nanomaterial” category.

Choosing whether to use CI 77266 isn’t necessarily about safety alone; it can also be about personal philosophy, comfort level with synthetic versus natural ingredients, and how much weight you place on ongoing research and regulatory oversight.

Makeup is highly individual, and personal preference plays an important role in deciding what feels right for you.