Dua Bright+ Radiance Renewal Serum

Unlike most brighteners that target tyrosinase (the enzyme that synthesizes melanin), TXA works further upstream. It basically blocks your cells from receiving the signal to produce pigment.

This makes it one of the rare actives that works on three pathways at once:

This makes it effective for treating melasma, post-inflammatory hyperpigmentation (PIH), and sun-induced dark spots.

The most effective cosmetic concentration sits between 2-5% and going higher doesn't boost results.

Side effects are generally mild; occasional irritation, flaking, or dryness have been reported at the start of use. Overall, this ingredient is pretty well tolerated, even by sensitive skin types.

Another perk of this ingredient is that it does not cause photosensitivity, so it's safe to use in the AM and PM.

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Kojic Acid is a similar ingredient.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

This ingredient may help soothe your skin by reducing inflammation. Emerging studies show it inhibits nitrous oxide production safely, therefore reducing inflammation.

Marigolds have been used in traditional medicine throughout Asia and Europe.

On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin

The more interesting story is underneath:

Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.

A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.

It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.

This ingredient gets along with pretty much everything and is typically used around 0.1-1%.

Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Ceramides are the lipids that hold your skin barrier together so they play a role in moisture retention and contribute to a stronger barrier.

The cream also improved scaling and itchiness for the group with atopic dermatitis.

How does Streptococcus Thermophilus Ferment work? Your skin naturally contains a fatty substance called sphingomyelin. S. thermophilus comes packed with enzymes that snip the sphingomyelin apart and turn it into ceramides.

So it's not adding ceramides from the outside but helping your skin make more of its own.

On top of that, a 2022 lab study found that S. thermophilus extract could calm down the overactive scarring process in skin cells. It tells cells to chill out instead of producing excess scar tissue. There's also some early stage research that hints at possible wound healing perks as well.

Last but not least, the type of ceramides that S. thermophilus creates (phytosphingosine), also happens to fight the bacteria that causes breakouts.

This ingredient may not be fungal acne safe, but not everyone will react to it.

This is because your skin contains ceramidases that break ceramides down into their components (free sphingosines and fatty acids) which can theoretically be used by Malassezia.

If this ferment can drive ceramide synthesis via sphingomyelin hydrolysis, it could generate the substrate that ceramidases could convert to Malassezia-available fatty acids.