Benev GF-DNA Serum
A serum with 15 ingredients.
Serum with 15 ingredients
Worth noting
Contains Mentha Piperita Oil, an EU-listed fragrance allergen.
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What's inside
Key Ingredients
Benefits
Concerns
Ingredients Explained
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterThis is a growth factor ingredient.
So what are growth factors? They're tiny messenger proteins your skin already makes on its own. Their job is to tell skin cells what to do: grow, repair, make more collagen, calm down after damage.
Our skin makes fewer of them as we age. This is a big part of why older skin heals slower and looks less bouncy.
The idea behind putting them in skincare is to "top up" the supply from the outside.
"Conditioned media" sounds mysterious but it's basically just leftover broth.
They're made in a lab where scientists grow human skin cells (fibroblasts) in a nutrient liquid. These cells release a cocktail of helpful proteins into that liquid as they live and grow.
Then, these cells are filtered out and the ingredient is the "conditioned" liquid now full of secreted goodies.
So what does neonatal mean here? It just means the original cells came from newborn tissue (usually donated foreskin), which tend to be younger, more active, and better at pumping out growth factors than adult cells.
Technically, this isn't one single ingredient, it's a mix of dozens of active molecules working together, including:
Studies find growth factor conditioned media can help with:
The evidence behind this ingredient is pretty solid too (and not just marketing).
A 24 week study of a fibroblast conditinoed media serum showed measurable improvements in the look of photodamaged skin, and these results were backed by actual skin biopsies rather than just before/after photoshoots.
And a broader review that pulled together many growth factor studies came to a similar conclusion: they generally help with fine lines, texture, firmness, and are well-tolerated.
It's also worth knowing the caveat that the review pointed out most of these serums also contained peptides, antioxidants, and exosomes.
The honest answer is there isn't a tidy "use at 1-2%" number the way there is for something like niacinamide.
This is because conditioned media isn't a single molecule. Brands add it as a percentage of a finished formula so that number is all over the map.
The serums built around it usually advertise very high levels (~50%) while others just use a splash. And the individual growth factors floating inside are actually present in very tiny amounts (think nano/micrograms per gram).
Here's one regulatory anchor point: the FDA has approved a wound healing gel that uses a pure growth factor at 0.01% (100 micrograms per gram). This shows the active growth factors themselves work at very low concentrations.
So the "50%" numbers you see on labels refer to the diluted broth and not the pure proteins.
The single most important thing to understand growth factors is that they are very fragile.
Dr. Zoe Draelos wrote this about them for Dermatology Times:
Independent lab work backs up the fragility.
Many growth factors lose a big chunk of their activity within a day or two sitting in water at room temperature and this is why smart formulating matters so much. Airless pumps, water-free formulas, and cool storage all help the ingredient survive long enough to do something. It's also a green flag if a brand can show real stability testing.
None of this means growth factor serums don't work; plenty of people get lovely results. It just means the formulation and packaging are doing a lot of the heavy lifting.
You may have heard a worry that growth factors "feed" skin cancer because their whole job is to encourage cells to multiply (this is called mitogenic activity).
It's a fair question to ask so here's the actual picture.
The theoretical concern is real enough that dermatologists take it seriously. There IS a hypothetical worry that they can encourage the wrong cells to grow in skin that already has sun damage or pre-cancerous spots.
Due to this, the cautious advice is to check with your dermatologist before using growth factor products if you have psoriasis, a history of skin cancer, or a lot of pre-cancerous sun damage.
Now the reassuring side:
There has been no documented pattern of growth factor products causing skin cancers despite millions of units sold over many years.
A large safety review of pure PDGF (one of the growth factors in these blends) found it to be non-toxic, non-mutagenic, and non-carcinogenic across decades of medical use. This is including repeated daily application to open wounds.
And a dermatology review specifically looking at topical EGF found no evidence that it stimulates cancer cells to grow (partly because these proteins are large and mostly stay near the surface).
The bottom line for a healthy person with no specific risk factor:
Growth factor conditioned media has a strong track record and is generally considered safe and well tolerated.
But be sure to loop in your dermatologist first if you have psoriasis, active or past skin cancer, or heavy sun damage. This is not because it's proven dangerous but because it's a sensible precaution while the long-term research keeps building.
The US allows human-derived growth factors so Human Neonatal Fibroblast Conditioned Media appears on labels.
In the EU, human-cell-derived ingredients are banned in cosmetics. EU products use plant-derived alternatives (barley is a common one) to get a similar effect.
Learn more about Human Neonatal Fibroblast Conditioned MediaGlycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Learn more about GlycerinCitrullus Lanatus Fruit Extract comes from the watermelon. Watermelon has antioxidant and anti-inflammatory properties.
Watermelons are rich in antioxidants such as Vitamin A, Vitamin C and lycopene. It also contains sugars and amino acids, such as arginine and glutathione.
Lycopene is a potent antioxidant. Besides helping to protect your skin against free-radical molecules, it also helps soothe the skin. Lycopene gives watermelon the distinct red color.
Learn more about Citrullus Lanatus Fruit ExtractWe don't have a description for Gossypium Hirsutum Extract yet.
Polysorbate 20 is a gentle, water-soluble emulsifier and mild surfactant. It stops oil and water from separating to keep your formulas blended and stable.
It also acts as a mild penetration enhancer by helping active ingredients absorb slightly better.
The common safety discussion around this ingredient involves a manufacturing byproduct called 1,4-dioxane.
Trace amounts can form during production but the EU's Scientific Committee on Consumer Safety has concluded that levels at/below 10 ppm in finished products are safe (commercial products consistently fall within acceptable margins).
True allergic reactions are uncommon and the CIR Expert Panel has confirmed this ingredient to be safe as used in cosmetics.
Because it is derived from lauric acid, it may not be fungal acne safe.
Learn more about Polysorbate 20Arabidopsis Thaliana Extract is an antioxidant.
Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.
Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:
It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.
Learn more about LecithinXanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.
Learn more about Xanthan GumLactic Acid is another well-loved alpha hydroxy acid (AHA). It is gentler than glycolic acid but still highly effective.
Its main role is to exfoliate the surface of the skin by loosening the “glue” that holds dead skin cells together. Shedding those old cells leads to smoother, softer, and more even-toned skin.
Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.
Like glycolic acid, it can:
Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.
Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.
To get results, choose products with a pH between 3-4.
Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.
Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.
When lactic acid shows up near the end of an ingredient list, it usually means the brand added just a tiny amount to adjust the product’s pH.
Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.
Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.
Read more about some other popular AHA's here:
Learn more about Lactic AcidCitrus Grandis Peel Oil is an essential oil that is derived from the peel of a Grapefruit. It is composed largely of limonene, which is a fragrance that can cause irritation for sensitive skin.
This essential oil is steam-distilled from peppermint leaves, also known as peppermint oil. It's mainly used for scent in skincare but also provides that signature "cooling" sensation.
Peppermint oil is a "feels amazing" ingredient until it doesn't.
At higher doses or for those with sensitive skin, methol-type cooling can quickly turn into burning/irritation. It can also trigger irritant dermatitis or even allergic contact dermatitis. In a large patch-test dataset, peppermint oil had a low but positive rate for this.
In cosmetics, Cosmetic Safety Reviews (CIR) concludes that peppermint oil is safe to use when formulated to be non-sensitizing with some restrictions; for instance, pulegone, a naturally occurring component of peppermint oil, should not exceed 1%.
Since peppermint oil contains fragrance allergens such as limonene, linalool, and menthol, it can be sensitizing for those with rosacea, eczema, a broken skin barrier, or just sensitive skin in general.
In Japan, this ingredient is known as Hakka Yu.
Learn more about Mentha Piperita OilPhenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Learn more about Phenoxyethanol1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.
It is a:
- Humectant, drawing moisture into the skin
- Emollient, helping to soften skin
- Solvent, dispersing and stabilizing formulas
- Preservative booster, enhancing the antimicrobial activity of other preservatives
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Learn more about Caprylyl GlycolReviews
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Where it's from
Benev is a American brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated May 7, 2026 • Added by reginasheynblat
