Avène Cicalfate+ Restorative Protective Cream - US Versus Avène Cicalfate+ Absorbing Soothing Spray
Updated on September 30, 2025
Overview
Suited For
They're both likely to be good for fighting acne, dry skin and scar healing
Free From
They both do not contain any harsh alcohols, common allergens, fragrances, parabens or silicones
What's Inside
They both contain sulfates
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Ingredient Info
Avène Cicalfate+ Restorative Protective Cream 18 ingredients
Avène Cicalfate+ Absorbing Soothing Spray 12 ingredients
What's inside
What's inside
At a glance
Click on any of the items below to learn more
Avène Cicalfate+ Restorative Protective Cream 18 ingredients
Avène Cicalfate+ Absorbing Soothing Spray 12 ingredients
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
We don't have a description for Aquaphilus Dolomiae Ferment Filtrate yet.
Arginine is an amino acid that is important for human development. Your body uses is it to produce hair keratin and skin collagen.
As a cosmetic ingredient, Arginine has antioxidant properties and can also help repair damaged skin. This ingredient is derived either synthetically or from animals.
Arginine isn't fungal acne safe when used in the presence of other lipids (fats, fatty acids, oils, esters, etc). Oils and fats occur naturally within the skin, so take caution when using Arginine if you're prone to fungal acne.
Learn more about ArginineCopper Sulfate is a type of sulfate.
Tromethamine helps balance the pH and improve the texture of a product. It is synthetically created.
As an emulsifier, Tromethamine prevents oil and water ingredients from separating. This helps stabilize the product and elongate a product's shelf life. Tromethamine also makes a product thicker.
Tromethamine helps balance the pH level of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.
Oral Tromethanmine is an anti-inflammatory drug but plays the role of masking, adding fragrance, and/or balancing pH in skincare.
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
Learn more about TromethamineWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!
Learn more about WaterZinc Oxide is a mineral broad-spectrum UV filter; it is the broadest UVA and UVB reflector approved by the FDA. It also has skin protectant and skin soothing properties.
Zinc oxide is one of the most effective broad-spectrum UV filters. It protects against UVB, UVAII, and UVAI. In comparison to its counterpart titanium dioxide, zinc oxide provides uniform and extended UVA protection.
Another great benefit? This ingredient is highly photostable so it won't degrade easily under sunlight.
A common myth is that mineral UV filters are widely believed to primarily reflect UV light.
However, modern research shows titanium dioxide absorbs UV radiation like chemical filters (~95% absorption & 5% reflection).
Zinc oxide has great skin soothing properties so you'll likely find this in sunscreens formulated for sensitive skin or babies/children. It is unlikely to cause "eye sting" like other sunscreen ingredients.
Regulatory agencies consider zinc oxide to be non-toxic and safe. It has also been shown to not penetrate the skin.
Unfortunately, this ingredient does leave a visible white cast. This is why mineral sunscreens are often less cosmetically elegant than chemical or hybrid ones.
In cosmetics, zinc oxide can be found in both non-nano and nano-sized forms. The nano version is used to reduce white cast and improve the texture of sunscreen formulas.
There are ongoing concerns surrounding nano-zinc oxide's impact on marine ecosystems and whether it can be absorbed into skin.
Regarding marine ecosystems and coral reefs, there is no conclusive evidence that any form of zinc oxide (or any other sunscreen ingredients) will cause harm. The science is still developing but many consumers are keeping a close eye on this issue.
Please note, many destinations have reef-safety sunscreen rules. For instance, the U.S. Virgin Islands advises all visitors to use non-nano mineral sunscreens.
There has also been some stir about whether micronized or nano zinc oxide has potential photoxicity and absorption through the skin/lungs.
An in-vitro (done in a test tube or petri dish) study demonstrated micronized zinc oxide to have potential phototoxicity. There's no need to fret; the EU Commission's Scientific Committee on Consumer Safety has stated, "The relevance of these findings needs to be clarified by appropriate investigations in vivo." Or in other words, further studies done on living organisms are needed to prove this.
Current research shows zinc oxide nanoparticles do not penetrate intact or sunburned skin. They either remain on the surface or in the outermost layer of dead skin (stratum corneum).
Zinc oxide is one of only two classified mineral UV filters with titanium dioxide being the other one.
Fun fact: Zinc has been used throughout history as an ingredient in paint and medicine. An Indian text from 500BC is believed to list zinc oxide as a salve for open wound. The Ancient Greek physician Dioscorides has also mentioned the use of zinc as an ointment in 1AD.
Learn more about Zinc OxideZinc Sulfate has antimicrobial and astringent properties. It is created synthetically from zinc and sulfuric acid.
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Avène Cicalfate+ Restorative Protective Cream 18 ingredients
Avène Cicalfate+ Absorbing Soothing Spray 12 ingredients

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