OPI Nature Strong Natural Origin Lacquer

Is it bad for your skin?

The answer comes down to concentration. Patch and wash studies have found highly concentrated alcohol-based hand rubs (60-100%) cause less barrier disruption than washing with a basic detergent like SLS. The only measurable effect in these studies was a temporary dip in skin hydration.

Concentrations below 12-15% in leave-on cosmetics is generally well-tolerated. Concentrations above start to see increased transepidermal water loss (TEWL) and reduced hydration.

In concentrations about 58%, it creates temporary channels in your skin's lipid layers to become more permeable and allow other ingredients to slip through easily.

This ingredient can be up to 80% of the formula in alcohol-based perfumes.

Overall, this ingredient is probably harmless if found lower down an ingredients list but worth side-eyeing if it's high up (especially if your barrier is already struggling).

Alcohol can worsen dry skin, eczema, and oily skin, especially at higher concentrations. This is because it can increase transepidermal water loss and decrease hydration to disrupt the skin barrier.

According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.

True allergic contact dermatitis to ethanol is uncommon, but be sure to patch test if you have dry or sensitive skin.

Other types of astringent alcohols include:

According to the National Rosacea Society based in the US, you should be mindful of products with these alcohols in the top half of ingredients.

Any type of sanitizing product will have high amounts of alcohol to help kill bacteria and viruses.

Fun fact: Mannitol can be found in foods as a sweetener. It can be naturally found in mushrooms, algae, fruits, and veggies.

This ingredient is also pretty picky about pH; it performs best at pH 6.5 or below.

At the right pH level, sorbic acid is "active" and can slip through the outer wall of a microbe. Once inside, it turns the cell's interior more acidic to shut down the microbe from the inside.

The EU caps this ingredient at 0.6% while the CIR has concluded it's safe at concentrations up to 1%. It's most often used around 0.05-0.2% in cosmetics.

Though this ingredient is considered low-sensitizing and well-tolerated, a very small number of people may have a contact allergy to it. Be sure to patch test if you have a history of allergies towards preservatives.

The unique structure of silica enhances the spreadability and adds smoothness, making it a great texture enhancer.

It is also used as an active carrier, emulsifier, and mattifier due to its ability to absorb excess oil.

In some products, tiny microneedles called spicules are made from silica or hydrolyzed sponge. When you rub them in, they lightly polish away dead skin layers and enhance the penetration of active ingredients.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Ci 77891 is commonly found in sunscreens due to its ability to block UV rays.

Some people may experience allergies from this dye, especially asthmatics and those with an aspirin intolerance.

This ingredient is common in foundations, lipsticks, and blushes. This color is described as brown/orangey red.

It has many secondary names such as Red 6 and Red 7. According to a manufacturer, Red 6 usually contains aluminum.

In the EU, both of these colors must be labeled as 'CI 77510'.

In the US, this ingredient can only be used if it meets strict FDA specifications. Certain versions even require batch-by-batch certification after extensive safety evaluation.

In the European Union, this ingredient is permitted as a colorant and classified as a "nanomaterial" based on its particle size (meaning it requires deeper assessment).

The EU Scientific Committee on Consumer Safety (SCCS) has reviewed nano-sized carbon black specifically and concluded that it does not pose a risk to human health when used in cosmetic products applied to healthy, intact skin and formulated to avoid inhalation.

Studies support this regulatory stance. Laboratory studies on nano-carbon black show potential for cytotoxicity and inflammatory effects in immune cells; it is important to highlight these findings are based on in vitro (not done on a living organism) testing or inhalation scenarios rather than normal topical cosmetic use.

Occupational studies involving industrial workers exposed to airborne carbon black have not shown a clear link between cumulative exposure and cancer risk. These findings are not directly applicable to cosmetics; cosmetic formulations bind pigments within creams, gels, and liquids that are not inhaled.

Overall, evidence shows that this ingredient is safe under regulatory guidelines and purity standards, especially when formulated to avoid airborne exposure.

Even with regulatory approval and a long history of use, some consumers might prefer to avoid ingredients that are petroleum-derived or that fall under the “nanomaterial” category.

Choosing whether to use CI 77266 isn’t necessarily about safety alone; it can also be about personal philosophy, comfort level with synthetic versus natural ingredients, and how much weight you place on ongoing research and regulatory oversight.

Makeup is highly individual, and personal preference plays an important role in deciding what feels right for you.