Obagi Rx C-Clarifying Serum - Normal to Dry
A highly rated prescription with 6 ingredients, including vitamin C.
Overview
What it is
Prescription with 6 ingredients that contains Vitamin C
Cool Features
It is fungal acne (malassezia) safe and reef safe
Suited For
It has ingredients that are good for anti aging, dry skin, brightening skin, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, fragrances, oils, parabens or silicones
Fun facts
Obagi is from United States. This product is used in 25 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Explained
Hydroquinone is a classic ingredient dermatologists use to fade dark spots (things like melasma, acne marks, sun spots, and freckles).
It works in two ways:
1. By blocking an enzyme called tyrosinase; your skin uses this to make melanin, or the pigment that causes dark spots.
2. By interfering with the pigment making cells themselves so less pigment shows up over time
Just know this ingredient fades spots near the surface of skin and not the deeper ones. It's usually used at 2-4% / twice a day for 3 months, and ALWAYS with sunscreen.
This ingredient is usually well tolerated with short-term use under medical guidance. But possible reactions include irritation, contact dermatitis, and lightening of the skin around the spot you're treating.
You might hear hydroquinone called "cancer-causing". That concern comes from studies where rats were fed high oral doses; no skin cancer cases have been linked to it after more than 50 years of people putting it on their skin.
Long-term, high-strength, and unsupervised use can lead to a condition called ochronosis. This is where the skin turns blue-grey color and sometimes causes nails to turn dark as well.
The rules around it vary by country.
The EU bans it in regular cosmetics and it is prescription only in the US, EU, Japan, Canada, and Australia. Anything you see on the shelf without a prescription is technically not allowed.
Check out the European alternative to hydroquinone here.
SkinSort would like to remind friends from around the world that all skin tones are beautiful!
Learn more about HydroquinonePropylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.
As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.
The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.
True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).
It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.
Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.
Learn more about Propylene GlycolWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterAscorbic Acid is is pure Vitamin C and is the biologically active form used directly by skin.
Not only is vitamin C great for your overall health and immune system, but it also has plenty of benefits for your skin. It is best supported by academic literature for:
Topical vitamin C has been shown to help neutralize oxidative stress from UV and pollution, helping to improve photoaging and hyperpigmentation when used consistently.
One clinical study found that using 5% topical vitamin C for six months improved signs of photodamaged skin, both on the surface and in the deeper structural layers of the skin.
While vitamin C doesn’t replace sunscreen, studies show it can boost photoprotection when combined with Vitamin E and ferulic acid. These two ingredients help improve stability and protective effects.
The big downside of this ingredient is formulation difficulty. Vitamin C is prone to oxidation and doesn't penetrate the skin unless formulated correctly. Research found that vitamin C absorbs into the skin best at a low pH (< 3.5) with about 20% being the upper limit for effective absorption.
Skin levels can saturate after repeated application; this means your skin won’t keep absorbing more once it’s full of vitamin C. This is why more isn’t always better with vitamin C and why very high concentrations don’t necessarily give extra benefits.
Ascorbic acid generally works well with many skincare ingredients but can be irritating when combined with other active ingredients. Strong oxidizing acne treatments like benzoyl peroxide can reduce the effectiveness of vitamin C if they are used at the same time; they are often recommended for use at different times of day.
Read more about other types of Vitamin C:
Foods rich with vitamin C include oranges, strawberries, broccoli, bell peppers, and more. When consuming Vitamin C, your skin receives a portion of the nutrients.
Learn more about Ascorbic AcidThis ingredient is a solvent. It helps dissolve active ingredients and alter the texture of products.
Propylene Carbonate is commonly used in makeup and with clay, such as montmorillonite or bentonite.
Studies show this ingredient to be safe for cosmetics. When it is undiluted, it can cause skin irritation. (It is always diluted in skincare and makeup). This ingredient is water-soluble.
Propylene Carbonate is created from propylene glycol and carbonic acid.
Learn more about Propylene CarbonateSodium Lauryl Sulfate (SLS) is a surfactant, cleansing agent, and foaming agent. You'll find it in a wide range of products from shampoos to face cleansers.
It:
The Cosmetic Ingredient Review Panel has assessed it in 1983, 2002, and 2005 and found it to be safe in formulations at low concentrations.
SLS is a well-documented skin irritant at higher concentrations or with prolonged exposure. It's actually the gold standard positive control used in dermatological patch testing, meaning doctors use it because they know it will cause a reaction in people.
In one large study of 43,000 patiences tested with 0.25% SLS, about 22% showed some level of reactivity. It increases transepidermal water loss that disrupts your outermost layer of skin.
Face cleansers often pair this ingredient with mild co-surfactants like Cocamidopropyl Betaine to buffer its harshness.
Just so you know, SLS does not trigger true allergic contact dermatitis. This just means it can irritate your skin but doesn't cause your immune system to develop a lasting allergy to it.
Despite internet rumors, SLS is not considered a carcinogen by any major regulatory body.
Learn more about Sodium Lauryl SulfateReviews
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Where it's from
Obagi is a American brand
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We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated May 31, 2025 • Added by Aries
