Kosumosu Organics Chinsei Seb Derm Serum

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Terpinen-4-ol is responsible for tea tree oil's broad-spectrum antimicrobial activity and makes it a well-researched option for acne.

Clinical studies support 5% tea tree oil as an effective topical treatment for mild to moderate acne. A study with 124 patients compared 5% tea tree oil gel to 5% benzoyl peroxide and both reduced acne (though tea tree oil worked more slowly).

Besides acne, it is also seen in anti-dandruff shampoos and scalp treatments for it's antimicrobial and anti-seborrheic properties.

Safety-wise, the allergic potential of low concentrations on healthy skin is considered low. However, oxidized (old or improperly stored) tea tree oil is a stronger sensitizer.

Irritation can also occur if using the undiluted oil on skin; it's best to use this ingredient as part of a carefully crafted cosmetic formula. This is because regulations require tea tree oil in cosmetics to be stabilized to prevent degradation.

This ingredient has been deemed safe up to 2% in shampoo, 1% in cleansers, and 0.1% in face cream by the EU's Scientific Committee on Consumer Safety (SCCS).

There is some lab evidence that tea tree oil is antifungal against Malassezia, but it is a supportive option at best and not a replacement for proven antifungal treatments.

When exposed to air, these two compounds become strong allergens. This ingredient exhibits cytotoxicity at low concentrations; amounts of 0.25% have been shown to damage skin cells.

A study from Japan found this ingredient caused lavender sensitivity after widespread exposure.

Lavender essential oil has some antimicrobial, antibacterial, and anti-inflammatory properties. However, the cons of this ingredient may outweight the pros.

More research is needed to confirm lavender essential oil's effects when used in aromatherapy.

Lavandula Angustifolia is known as the English Lavender and famous for creating purple fields in Provence, France.

Lab studies credit this oil with antioxidant, anti-inflammatory, and antimicrobial activity. Some research even show rosemary compounds calming acne-related inflammation.

The Cosmetic Ingredient Review (CIR) has concluded rosemary-derived ingredients to be safe when formulated to be nonsensitizing.

Since this is a fragrant essential oil, the main concern is for fragrance-sensitive folks.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

The EU requires it to be named on the label above 0.001% in leave-on and 0.01% in rinse-off products.

Fresh linalool is a weak sensitizer but air exposure turns some of it into hydroperoxides, which are strong sensitizers. Those oxidation products are the actual allergy concern.

Patch-test clinics see positive reactions to linalool hydroperoxides in about 4% to 12% of dermatitis patients depending on country and test concentration.

Resassuringly, one analytical study found hydroperoxide levels in real fragranced products to be orders of magnitude below what induced sensitization in animal studies with no evidence of oxidation building up during normal storage.

The practical takeaway is that linalool is fine for most people but worth avoiding if you have a confirmed fragrance contact allergy or a badly compromised barrier.

Products stored a long time after opening are also the high-risk scenario since that is when oxidation happens.

The scent of linalool is described as floral, spicy tropical, and citrus-like.

You'll typically see this ingredient used in very small amounts; anything above 0.001% in a leave-on product or 0.01% in a rinse-off has to be named on the label in the EU. The citrus oils that carry it sit around 0.5-1% in a finished formula.

Fresh limonene is a weak allergen; the real issue is that it slowly reacts with air and then breaks down from oxidation to create hydroperoxides (which are strong sensitizers). This is why suppliers are required to keep the peroxide value below 20 mmol.

Positive reactions in people being investigated for eczema vary:

It's worth skipping if you have a known fragrance allergy or a compromised barrier, but the risk is low for most people.

Older or long-opened products are also more likely to bother you than fresh ones due to oxidation.