ORLY No Bite Nail Bite Deterrent

This ingredient gets a bad rep because it is irritating and drying due to its astringent property. Astringents draw out natural oils in tissue to constrict pores and dry out your skin.

However, alcohol denat. is not all that bad.

Due to its low molecular weight, alcohol denat. tends to evaporate quickly. One study on pig skin found half of applied alcohol evaporated in 10 seconds and less than 3% stayed on skin.

This also helps other ingredients become better absorbed upon application.

Studies are conflicted about whether this ingredient causes skin dehydration. One study from 2005 found adding emollients to propanol-based sanitizer decreased skin dryness and irritation. Another study found irritation only occurs if your skin is already damaged.

Small amounts of alcohol are generally tolerated by oily skin or people who live in humid environments.

The rule of thumb is this ingredient will probably not affect your skin much if it is near the end of an ingredients list.

One thing to note:
People with ALDH2 (aldehyde dehydrogenase 2) deficiency may experience skin irritation from continued alcohol use. About 8% of the world's population have this deficiency.

The Cosmetic Ingredient Review Expert Panel has determined denatured alcohols to be safe for use in concentrations between 0.05% and 12% (depending on which denaturant is used).

Also...

This ingredient has antimicrobial and solvent properties.

The antimicrobial property helps preserve products and increase their shelf life. As a solvent, it helps dissolve other ingredients.

Look for formulas that contain glycerin, hyaluronic acid, or panthenol if you want to offset any drying effect.

This ingredient will trip away your skin's natural oils/lipids that help it lock in moisture. This can worsen dryness, trigger eczema flare-ups, and aggravate rosacea.

Be sure to patch test any product with this ingredient if you have dry or sensitive skin, eczema, or rosacea.

It is also used to make a product more thick.

Fun fact: This ingredient is the most bitter known compound. The bitter flavor is often used to deter consumption.

On concentrations, neither the EU nor the FDA sets a hard number. The EU allows it with purity limits on leftover manufacturing residues and the FDA allows it in externally applied cosmetics at levels consistent with batch-certified good manufacturing practice.

Industry reports around 0.5% concentration usage in leave-on products, but most products use far less because it's a pretty strong dye.

The one rule that both regions share is that it isn't allowed anywhere it would touch mucous membranes (so no lipstick or eye products).

That restriction comes from an unresolved 2005 EU data request on how much of the dye penetrates skin and breaks down there, and not from any reported consumer harm.

Allergy risk is low and a guinea pig study ranked it a much weaker sensitizer than common hair-dye chemicals. But the same study found animals sensitized to paraphenylenediamine sometimes cross-reacted to it, so it's worth flagging for a patch test if you have a known permanant-hair-dye allergy.