Dermazen Calming Seborrheic Serum
A serum with 12 ingredients, including niacinamide, exfoliants, and hyaluronic acid.
Overview
What it is
Serum with 12 ingredients that contains exfoliants, hyaluronic acid, niacinamide and urea
Cool Features
It is cruelty-free, fungal acne (malassezia) safe, and reef safe
Suited For
It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture
Free From
It doesn't contain any harsh alcohols, common allergens, parabens, silicones or sulfates
Fun facts
Dermazen is from United States. This product is used in 100 routines created by our community.
We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.
What's inside
Ingredients List
Urea 5%
BufferingNiacinamide 3%
SmoothingWater
Skin ConditioningAloe Barbadensis Leaf Juice
Skin ConditioningColloidal Silver
Antimicrobial
Active Ingredients:
Urea 5%, Niacinamide 3%
Inactive Ingredients:
Water, Aloe Barbadensis Leaf Juice, Colloidal Silver, Xylitol, Sea Salt, Dimethyl Sulfone, Hyaluronic Acid, Citrus Grandis Seed Extract, Melaleuca Alternifolia Leaf Oil, Rosmarinus Officinalis Leaf Oil
Key Ingredients
Benefits
Concerns
Ingredients Explained
Urea is also called carbamide and is the diamide of carbonic acid. In cosmetics, urea is used to hydrate the skin. It also provides exfoliation in higher concentrations.
As a humectant, urea helps draw moisture from the air and from deep within the skin. This helps hydrate your skin. Studies show urea is an effective moisturizer for dry skin conditions. 40% urea is typical in medications for treating eczema and other skin conditions.
Urea has the strongest exfoliation effect in concentrations higher than 10%. It is a keratolytic agent, meaning it breaks down the keratin protein in the top layer of skin. This helps remove dead skin cells and flaking skin.
In medicine, urea has been shown to help increase the potency of other ingredients, such as fungal treatments.
Humans and animals use urea to metabolize nitrogen-containing compounds. Urea is highly soluble in water. Once dissolved, it is neither acidic nor alkaline.
Urea is actually one of the more well-studied and well-supported ingredients out there if you have eczema.
Clinical trials have shown that urea creams in the 5 - 10% range can:
Higher concentrations (20 -30%) can also help with thickened, scaly patches but is also more likely to sting on active flares.
Skip urea if you have rosacea. The AAD (American Academy of Dermatology) lists it alongside alcohol, menthol, and fragrance as a potential irritant for rosacea-prone skin. Urea's keratolytic and penetration-enhancing properties can trigger stinging, burning, and redness.
As always, your skin is unique, so definitely check in with your dermatologist.
Learn more about UreaNiacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.
And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.
You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.
In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.
If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.
When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.
When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.
In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).
Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.
Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.
The type of niacinamide used in skincare is synthetically created.
Learn more about NiacinamideWater. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Learn more about WaterAloe Barbadensis Leaf Juice comes from leaves of the aloe plant. Aloe Barbadensis Leaf Juice is best known for helping to soothe sunburns. It is also anti-inflammatory, moisturizing, antiseptic, and can help heal wounds.
Aloe is packed with good stuff including Vitamins A, C, and E. These vitamins are antioxidants, which help fight free-radicals and the damage they may cause. Free-radicals are molecules that may damage your skin cells, such as pollution.
Aloe Barbadensis Leaf Juice also contains sugars. These sugars come in the form of monosaccharides and polysaccharides, folic acid, and choline. These sugars are able to help bind moisture to skin.
It also contains minerals such as calcium, 12 anthraquinones, fatty acids, amino acids, and Vitamin B12.
Learn more about Aloe Barbadensis Leaf JuiceColloidal Silver is mixture of tiny silver particles in a liquid base. It has antimicrobial properties.
Silver ions work by disrupting the cell membranes of bacteria that ultimately leads to cell death; this is why you'll see it appear in wound dressings, acne treatments, and products for acne-prone skin.
Silver nanoparticle gel performed comparably to the antiobiotic clindamcyin in a double-blinded, randomized study for treating moderate acne (both were combined with benzoyl peroxide).
It should be noted the overall body of clinical evidence is still pretty thin, and some in-vitro studies have found that commercially available colloidal silver solutions didn't actually show antimicrobial activity against tested organisms.
The most well-known risk of using this ingredient is argyria. Argyria is the condition where silver builds up in the body's tissues and causes a permanent bluish-gray skin discoloration (and this is mostly associated with oral ingestion rather than topical use).
The FDA ruled in 1999 that over-the-counter colloidal silver products are not generally recognized as safe and effective and the NCCIH notes that silver has no known beneficial function in the body and is not an essential mineral.
It's a good idea to talk to a dermatologist first and stick to well-formulated topical products if you're considering a colloidal silver skincare product.
Learn more about Colloidal SilverXylitol is a humectant and prebiotic. It can help with dry skin.
In studies, xylitol has been shown to improve dry skin. It decreased transepidermal water loss, or when water passes through the skin and evaporates. Xylitol also showed to help improve the biomechanical properties of the skin barrier.
The prebiotic property of xylitol may also help reinforce our skin's natural microbiome. Having a healthy microbiome prevents infection by bad bacteria and helps with hydration.
As a humectant, Xylitol helps draw moisture from both the air and from deeper skin layers. This helps keep skin hydrated.
Xylitol is a sugar alcohol and commonly used as a sugar substitute. It is naturally occurring in plants such as strawberries and pumpkin.
Learn more about XylitolSea salt has abrasive or exfoliation properties. It can sensitize and dry out the skin.
Dimethyl Sulfone is an organic compound that naturally contains sulfur. It is used as a solvent due to its stability. Solvents help mix and stabilize other ingredients.
Studies show taking Dimethyl Sulfone (also known as methylsulfonylmethane or MSM) orally may help reduce the depth of wrinkles. We recommend speaking with a professional if you have any questions or concerns about this ingredient.
Hyaluronic acid (HA) is a glycosaminoglycan (basically a long sugar chain) that your skin already makes on its own. In your skin, HA lives in the extracellular matrix and acts as the body's moisture reservoir.
Topically, HA is a humectant that binds water and helps skin look more plump, smooth, and hydrated.
The only catch is that HA isn't a single thing; it actually comes in a wide range of molecular weights (~50 - 2,000+ kDA) and size matters.
Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.
This is why the best HA serums blend the two sizes together so you get the best of both worlds.
The majority of cosmetic HA is produced by bacterial fermentation, typically using Streptococcus or Bacillus strains. Typical use levels in skincare sit around 0.1-2%.
A clinical study using a 0.2% low-molecular weight HA gel showed improvement in facial seborrheic dermatitis with excellent tolerance.
These are some other common types of Hyaluronic Acid:
Learn more about Hyaluronic AcidCitrus Grandis Seed Extract is a fragrance.
This ingredient is also known as tea tree oil. It has antioxidant, anti-inflammatory, and antimicrobial properties.
Tea tree oil is a complex lipophilic (fat-loving) oil that contains around 100 compounds with terpinen-4-ol being the most abundant (~40%).
Terpinen-4-ol is responsible for tea tree oil's broad-spectrum antimicrobial activity and makes it a well-researched option for acne.
Clinical studies support 5% tea tree oil as an effective topical treatment for mild to moderate acne. A study with 124 patients compared 5% tea tree oil gel to 5% benzoyl peroxide and both reduced acne (though tea tree oil worked more slowly).
Besides acne, it is also seen in anti-dandruff shampoos and scalp treatments for it's antimicrobial and anti-seborrheic properties.
Safety-wise, the allergic potential of low concentrations on healthy skin is considered low. However, oxidized (old or improperly stored) tea tree oil is a stronger sensitizer.
Irritation can also occur if using the undiluted oil on skin; it's best to use this ingredient as part of a carefully crafted cosmetic formula. This is because regulations require tea tree oil in cosmetics to be stabilized to prevent degradation.
This ingredient has been deemed safe up to 2% in shampoo, 1% in cleansers, and 0.1% in face cream by the EU's Scientific Committee on Consumer Safety (SCCS).
There is some lab evidence that tea tree oil is antifungal against Malassezia, but it is a supportive option at best and not a replacement for proven antifungal treatments.
Learn more about Melaleuca Alternifolia Leaf OilRosmarinus Officinalis Leaf Oil is an essential oil also known as rosemary essential oil. In skincare, it is a skin conditioning agent and also acts as a natural fragrance that gives products a fresh/herby smell.
The oil is a mix of over 100 volatile compounds with 1,8-cineole, α-pinene, camphor, and verbenone usually leading the pack.
Lab studies credit this oil with antioxidant, anti-inflammatory, and antimicrobial activity. Some research even show rosemary compounds calming acne-related inflammation.
The Cosmetic Ingredient Review (CIR) has concluded rosemary-derived ingredients to be safe when formulated to be nonsensitizing.
Since this is a fragrant essential oil, the main concern is for fragrance-sensitive folks.
Learn more about Rosmarinus Officinalis Leaf OilReviews
No written reviews yet. Be the first to review this product.
Recent searches
Search reviews by skin type, ingredient, or keyword.
Where it's from
Dermazen is a American brand
Often compared with
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated November 26, 2023 • Added by KatharineYoung_830