Nurx Dark Spots Formula
A prescription with 5 ingredients, including retinoid, azelaic acid, and kojic acid.
Prescription with 5 ingredients that contains azelaic acid, kojic acid and retinoid
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Ingredients List
Azelaic Acid 6%
BufferingKojic Acid 6%
AntioxidantHydroquinone 4%
StabilisingHydrocortisone 1%
Tretinoin 0.05%
Skin Conditioning
Active Ingredients:
Azelaic Acid 6%, Kojic Acid 6%, Hydroquinone 4%, Hydrocortisone 1%, Tretinoin 0.05%
Inactive Ingredients:
Key Ingredients
Benefits
Concerns
Ingredients Explained
Azelaic acid is a multitasker ingredient that helps treat acne, pigmentation, and irritation. It is a great option for sensitive skin.
What makes it special?
OTC Azelaic acid is usually available in concentrations from 10-15% and anything over requires a prescription.
Here's what each tier does best:
Unlike other acids, azelaic acid will not make your skin more photosensitive/sun sensitive.
Though this ingredient is naturally occurring in grains like wheat, rye, and barley, it is usually synthetically created for cosmetics to ensure stability and effectiveness.
Learn more about Azelaic AcidKojic Acid is a naturally occurring organic acid that is produced during the fermentation of certain fungi. It is one of the most well-studied brightening ingredients (tyrosinase inhibitors) out there.
That's why you'll see Kojic Acid in products that target dark spots, hyperpigmentation, and general uneven skin tone. It also pairs well with other brightening actives like Alpha Arbutin, Glycolic Acid, and Vitamin C derivatives.
By latching onto the copper that the enzyme tyrosinase needs to function, Kojic Acid prevents less pigment from being made. It's so well-established that researchers regularly use it as the go-to benchmark when testing new brightening ingredients.
Some other perks include documented antioxidant and antimicrobial properties. The The CIR (Cosmetic Ingredient Review) Expert Panel concluded Kojic Acid is safe for use in cosmetic products at concentrations up to 1% and the EU's SCCS (Scientific Committee on Consumer Safety) considers it safe as a skin lightening agent at concentrations up to 0.7%.
One thing to know about Kojic Acid is that stability is its weak spot; it is sensitive to light, heat, and air exposure and will oxidize/turn brown in formulations. Its derivative, Kojic Dipalmitate, was developed as a stable alternative.
Some individuals have reported contact sensitization so be sure to patch test if you have reactive or sensitive skin.
Fun fact: It was first discovered in 1907 and naturally occurs in the production of sake, soy sauce, and miso.
Learn more about Kojic AcidHydroquinone is a classic ingredient dermatologists use to fade dark spots (things like melasma, acne marks, sun spots, and freckles).
It works in two ways:
1. By blocking an enzyme called tyrosinase; your skin uses this to make melanin, or the pigment that causes dark spots.
2. By interfering with the pigment making cells themselves so less pigment shows up over time
Just know this ingredient fades spots near the surface of skin and not the deeper ones. It's usually used at 2-4% / twice a day for 3 months, and ALWAYS with sunscreen.
This ingredient is usually well tolerated with short-term use under medical guidance. But possible reactions include irritation, contact dermatitis, and lightening of the skin around the spot you're treating.
You might hear hydroquinone called "cancer-causing". That concern comes from studies where rats were fed high oral doses; no skin cancer cases have been linked to it after more than 50 years of people putting it on their skin.
Long-term, high-strength, and unsupervised use can lead to a condition called ochronosis. This is where the skin turns blue-grey color and sometimes causes nails to turn dark as well.
The rules around it vary by country.
The EU bans it in regular cosmetics and it is prescription only in the US, EU, Japan, Canada, and Australia. Anything you see on the shelf without a prescription is technically not allowed.
Check out the European alternative to hydroquinone here.
SkinSort would like to remind friends from around the world that all skin tones are beautiful!
Learn more about HydroquinoneHydrocortisone is the name for the hormone cortisol when used in medication.
It is medication and not technically a cosmetic ingredient. Most countries allow topical creams to contain up between 0.05 - 2.5% (depending on the country) of hydrocortisone without a prescription. Higher amounts usually require a prescription from a professional.
Hydrocortisone can help relieve rashes, eczema, itching, and other inflammation induced skin conditions.
We recommend speaking with a professional about using this ingredient.
Learn more about HydrocortisoneTretinoin (aka retinoic acid) is the gold standard retinoid in dermatology because it's the form of vitamin A that your skin can use right away. It's a prescription drug and regulated as medication in most countries.
Unlike retinol, it skips the conversion steps and goes straight to work.
Inside your skin cells, it binds to receptors called retinoic acid receptors and switches on the genes that control how skin cells behave.
For acne, it helps your skin shed dead cells properly instead of letting them build up and clog your pores (this is what turns into blackheads and pimples). It also calms redness/swelling, which is why it's a FDA-approved acne treatment.
Tretinoin also tells your skin to make more collagen and slows down the stuff that breaks collagen apart too. Over time, your skin looks smoother, softer, and more even, with fewer lines lines and sun spots.
The evidence for this ingredient is strong:
A systematic review of randomized controlled trials found that topical tretinoin consistently improved wrinkles, pigmentation, sallowness, and dark spots. Results typically showed up as early as one month and lasted out to 24 months.
All studies also found this ingredient to be safe and well-tolerated.
Typical concentrations run from about 0.01-0.1%, with 0.025%-0.1% being the usual range studied for photoaging and a 0.05% cream producing measurable wrinkle/roughness improvements in large six-month trials.
The main trade-off is irritation; dryness, peeling, redness, and sun sensitivity are common in the first few weeks so be sure to pair it well with a good moisturizer and daily sunscreen.
Learn about a form of retinoid you can purchase at the store, retinol.
Learn more about TretinoinReviews
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Where it's from
Nurx is a American brand
We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.
The data we've presented on this page has been verified by a member of the SkinSort Team.
Read more about us· Updated May 29, 2026 • Added by leeannec