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Updated on February 15, 2024

Overview

What they are

These products are both vegan, cruelty-free, and reef safe ampoules. They have a total of 8 ingredients in common

Cool Features

They both contain hyaluronic acid, niacinamide and peptides

Suited For

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, oily skin, reducing pores and dark spots

Free From

They both do not contain any harsh alcohols, common allergens, oils, parabens, silicones or sulfates

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Isntree TW-Real Bifida Ampoule
Isntree TW-Real Bifida Ampoule
Ampoule
South Korean Brand South Korea
ma:nyo Bifida Complex Ampoule
ma:nyo Bifida Complex Ampoule
Ampoule
South Korean Brand South Korea

Ingredient Info

Click any item below to learn more and see relevant ingredients

At a glance

Click on any of the items below to learn more

Notable Ingredients

Benefits

Notable Ingredients

Benefits

Ingredients Side-by-side

found in both products
TW-Real Bifida Ampoule
Bifida Ferment Lysate Skin Conditioning
Helps hydrate Dry Skin

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Dipropylene Glycol Masking, Solvent

Dipropylene Glycol is a synthetically created stabilizer and solvent. It is a part of the glycol class in the alcohol family.

Disliked Full details ->
Niacinamide Smoothing
Niacinamide  •  6 Benefits

Niacinamide has emerged as an all-star ingredient due to its many benefits.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Lactobacillus/Pumpkin Ferment Extract Skin Conditioning

We don't have a description for Lactobacillus/Pumpkin Ferment Extract.

Lactobacillus/Soybean Ferment Extract Skin Conditioning

This ingredient is created by fermenting soybean extract with the bacteria, lactobacillus.

Rice Ferment Filtrate Skin Conditioning
2 Benefits

Rice Ferment Filtrate is created by fermenting rice, or oryza sativa. A common name for this ingredient is sake, the traditional Japanese fermented rice alcoholic beverage.

Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0
Hyaluronic Acid

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Hydrolyzed Collagen Emollient, Humectant, Skin Conditioning
Helps with Anti-Aging

Collagen is the most abundant type of structural protein found in your body. In your skin, it is responsible for keeping it firm and youthful.

Salix Alba Bark Extract Astringent, Skin Conditioning, Soothing
Good for Oily Skin

Salix Alba Bark Extract comes from the white willow tree, which is native to Europe and Central Asia.

Origanum Vulgare Leaf Extract Skin Conditioning

We don't have a description for Origanum Vulgare Leaf Extract.

Unknown Full details ->
Cinnamomum Zeylanicum Bark Extract Antimicrobial, Antioxidant, Astringent
Antioxidant  •  Fragrance

Cinnamomum Zeylanicum Bark Extract is an antioxidant and is a fragrance.

Unknown Full details ->
Portulaca Oleracea Extract Skin Conditioning

Portulaca Oleracea Extract is an extract of the whole plant of the Purslane, Portulaca oleracea L., Portulacaceae. It has anti-inflammatory, antioxidant, and hydrating properties.

Chamaecyparis Obtusa Leaf Extract Skin Conditioning

We don't have a description for Chamaecyparis Obtusa Leaf Extract.

Beta-Glucan Skin Conditioning
Helps reduce Skin Redness

Beta-Glucan is a polysaccharide. It can be derived from the cell walls of seaweed, oats, yeast, and fungi.

Palmitoyl Oligopeptide Cleansing, Skin Conditioning
Peptide  •  Not safe for Fungal Acne

Palmitoyl Oligopeptide is a form of peptide. It is created by blending peptides with palmitic acid. Peptides are building blocks for protein.

Copper Tripeptide-1 Skin Conditioning
Peptide  •  Helps with Anti-Aging

Copper Tripeptide-1 is a peptide naturally found in body fluids. Peptides are building blocks for protein.

Acetyl Hexapeptide-8 Humectant, Skin Conditioning
Peptide

Acetyl Hexapeptide-8 is a peptide. A common name for this peptide is Argireline.

Allantoin Skin Conditioning, Skin Protecting, Soothing
0 / 0
3 Benefits

Allantoin plays a role in soothing and moisturizing the skin. Because of this, it is often added to products with strong active ingredients.

0 Com. / 0 Irr.
Hydroxyethylcellulose Emulsion Stabilising, Stabilising

Hydroxyethylcellulose is used to improve the texture of products. It is created from a chemical reaction involving ethylene oxide and alkali-cellulose. Cellulose is a sugar found in plant cell walls and help give plants structure.

Panthenol Skin Conditioning
0 / 0
Helps reduce irritation

Panthenol (also referred to as pro-vitamin B5) is a common ingredient that helps hydrate and soothe the skin.

0 Com. / 0 Irr.
Carbomer Emulsion Stabilising, Gel Forming
1 / 0

Carbomer is a polymer of acrylic acid. Its main role is to create gel consistency within products.

1 Com. / 0 Irr.
Disliked Full details ->
Arginine Masking, Skin Conditioning
Not safe for Fungal Acne

Arginine is an amino acid that is important for human development. Your body uses is it to produce hair keratin and skin collagen.

Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Scutellaria Baicalensis Root Extract Astringent, Humectant, Soothing
Good for Scar Healing

Scutellaria Baicalensis Root Extract comes from the Baikal skullcap or Chinese skullcap plant. This plant is native to Northeast Asia and can be found in China, Mongolia, Korea, and Siberia.

Illicium Verum Fruit Extract Perfuming, Skin Conditioning
Fragrance

Illicium Verum Fruit Extract is a fragrance.

Adenosine Skin Conditioning
2 Benefits

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

1,2-Hexanediol Skin Conditioning, Solvent

1,2-Hexanediol is a multi-tasker ingredient. It acts as a preservative to increase shelf-life and can aid other preservatives in preventing microbe growth. 1,2-Hexanediol also helps the skin retain moisture as a humectant.

Disodium EDTA

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

Disliked Full details ->
Bifida Complex Ampoule
Bifida Ferment Lysate Skin Conditioning
Helps hydrate Dry Skin

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Lactobacillus/Pumpkin Fruit Ferment Filtrate Skin Conditioning

We don't have a description for Lactobacillus/Pumpkin Fruit Ferment Filtrate.

Niacinamide Smoothing
Niacinamide  •  6 Benefits

Niacinamide has emerged as an all-star ingredient due to its many benefits.

Butylene Glycol Humectant, Masking, Skin Conditioning
1 / 0

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

1 Com. / 0 Irr.
Acetyl Hexapeptide-8 Humectant, Skin Conditioning
Peptide

Acetyl Hexapeptide-8 is a peptide. A common name for this peptide is Argireline.

Aureobasidium Pullulans Ferment Skin Conditioning

We don't have a description for Aureobasidium Pullulans Ferment.

Hydrolyzed Algin

We don't have a description for Hydrolyzed Algin.

Caffeine Skin Conditioning

Caffeine is most associated with coffee, tea, and cacao. In skincare, it helps with calming inflammation and anti-aging.

Panax Ginseng Root Extract Emollient, Skin Protecting, Tonic
2 Benefits

Panax Ginseng Root is a popular herb from Asia. This root contains antioxidants, favonoids, and vitamins B12 and D.

Panax Ginseng Callus Culture Extract Skin Conditioning

This ingredient comes from the callus cells of ginseng.

Glycerin Humectant, Skin Conditioning, Skin Protecting
0 / 0
2 Benefits

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

0 Com. / 0 Irr.
Epigallocatechin Gallate Antioxidant
Antioxidant

EGCG is most famous for being found in green tea. It is a type of catechin, a potent antioxidant.

Zanthoxylum Piperitum Fruit Extract Skin Conditioning

Zanthoxylum Piperitum Fruit Extract comes from the Japanese Pepper, also known as the Prickly Ash. This plant is native to the Korean peninsula and Japan.

Pulsatilla Koreana Extract Skin Conditioning

Pulsatilla Koreana Extract comes from the Korean pasque flower. This flower is used in traditional Korean medicine.

Unknown Full details ->
Usnea Barbata Extract

We don't have a description for Usnea Barbata Extract.

Unknown Full details ->
Copper Tripeptide-1 Skin Conditioning
Peptide  •  Helps with Anti-Aging

Copper Tripeptide-1 is a peptide naturally found in body fluids. Peptides are building blocks for protein.

Physalis Alkekengi Fruit Extract Skin Conditioning

We don't have a description for Physalis Alkekengi Fruit Extract.

Unknown Full details ->
Methyl Gluceth-20 Humectant, Moisturising

Methyl Gluceth-20 is a humectant. Humectants help draw moisture from the air to your skin.

Sodium Hyaluronate Humectant, Skin Conditioning
0 / 0
Hyaluronic Acid

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

0 Com. / 0 Irr.
Adenosine Skin Conditioning
2 Benefits

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Skin Conditioning
Liked

Bifida Ferment Lysate is derived from the fermentation of Bifida bacteria (often with dairy). It is a probiotic and helps to strengthen our skin's microbiome.

Having a healthy microbiome helps protect our skin against infection. It also helps our skin stay hydrated and healthy.

Studies also show this ingredient to be a promising soothing ingredient for sensitive skin.

Learn more about Bifida Ferment Lysate
Smoothing
Loved

Niacinamide has emerged as an all-star ingredient due to its many benefits.

It is known to treat acne by reducing inflammation. It also helps fade dark-spots and strengthen the skin by promoting the growth of the ceramide barrier.

Other benefits include smoothing wrinkles and minimizing redness.

The cherry on top? Niacinamide can also help build keratin, a protein that keeps skin firm.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

Niacinamide can be mixed with other ingredients to boost benefits. For instance, it has shown to be effective when used with copper, folic acid, and zinc to treat acne.

Learn more about Niacinamide
Humectant, Skin Conditioning, Skin Protecting
Loved

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Humectant, Skin Conditioning
Loved

Sodium Hyaluronate is hyaluronic acid's salt form. It is commonly derived from the sodium salt of hyaluronic acid.

Like hyaluronic acid, it is great at holding water and acts as a humectant. This makes it a great skin hydrating ingredient.

Sodium Hyaluronate is naturally occurring in our bodies and is mostly found in eye fluid and joints.

These are some other common types of Hyaluronic Acid:

Learn more about Sodium Hyaluronate
Skin Conditioning
Loved

Copper Tripeptide-1 is a peptide naturally found in body fluids. Peptides are building blocks for protein.

Studies show this ingredient tells our body to create more collagen and elastin. Collagen is a protein that makes connective tissue. Elastin is the protein responsible for giving our skin elasticity. Our bodies start to slow down collagen and elastin production with age.

Boosting collagen and elastin production can help create a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin. It's a win-win situation!

Studies show this ingredient can help with scar healing. This is because it breaks down damaged collagen, the main component of scar tissue. It may also help with reducing sunspots, acne scars, and uneven skin tone.

This ingredient is also an antioxidant. Antioxidants help the body fight off free-radicals. Free radicals are molecules that damage our cells, such as pollution and tobacco smoke.

More benefits: Copper Tripeptide-1 helps maintain tissues in blood vessels and promote natural hyaluronic acid in skin.

Read more about other common types of peptides here:

Learn more about Copper Tripeptide-1
Humectant, Skin Conditioning
Loved

Acetyl Hexapeptide-8 is a peptide. A common name for this peptide is Argireline.

Argireline has a similar function to botox. It prevents muscle movement and contractions. By preventing muscles from moving, Argireline also prohibits the formation of fine lines and wrinkles. However, research is lacking in proving this ingredient to be as effective as botox.

Argireline tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Read more about other common types of peptides here:

Learn more about Acetyl Hexapeptide-8
Humectant, Masking, Skin Conditioning
Mixed

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

  • It is a solvent, meaning that it helps to dissolve other ingredients. This also enhances the absorption of the product into one's skin.
  • It is a humectant, which means that it helps attract moisture into the skin.
  • It helps improve product application.

Overall, Butylene Glycol is a safe and well-rounded ingredient. It is unlikely to irritate skin, and works well with pretty much all other ingredients.

Skin Conditioning
Loved

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Learn more about Adenosine

Ingredient Ratings

Here's what our community thinks of the ingredients in these two products.

TW-Real Bifida Ampoule
20
4
3
2
liked
mixed
disliked
not rated
Bifida Complex Ampoule
14
3
3
liked
mixed
disliked
not rated

When to use

86 Routines
38% use in am
62% use in pm
90% use every day
When to use See routines that use it ->
100 Routines
39% use in am
61% use in pm
94% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Isntree TW-Real Bifida Ampoule 29 ingredients

5.0 /5
from 1 rating
Marifsts's avatar

Marifsts

8 months ago · Combination Skin
Review

Worthy a lot
I'm using as a dupe to Lancome Gentifique serum and I love it, my skin is soft and feels healthier, I can describe, but is a perfect dupe

ma:nyo Bifida Complex Ampoule 20 ingredients

5.0 /5
from 1 rating
Expensive (1) Hydrating (1) No Scent (1) Oily (1) Works Well (1)
nja's avatar

nja

4 months ago · Sensitive Skin
Review

This is some pretty amazing stuff, it's what makes my skin glow! Bifida is great for the skin barrier and pumpkin fruit ferment filtrate has...

This is some pretty amazing stuff, it's what makes my skin glow! Bifida is great for the skin barrier and pumpkin fruit ferment filtrate has exfoliation properties. It also has peptides and niacinamide. Basically te entire INCI is amazing and it's also FA safe. The other version - Bifida BIOME Complex Ampoule - is *not* FA safe but it's very easy to get them mixed up because they look identical.
This ampoule exfoliates the skin and quite effectively, at least in my experience! So if you have very sensitive skin or are using any actives, keep that in mind. My skin gets a little flushed with this but I am using tretinoin. For now I use it once a week but when my skin gets totally used to tret, I plan on using it more because I love it!! It is kind of oily on the skin but it doesn't bother me when it works so well. The glow it gives is unmached!!