Soluble Proteoglycan

Soluble Proteoglycan is the name used for water-soluble proteoglycans, or large “gel-like” skin matrix molecules. These molecules help skin hold onto water and support the structure around cells.

In a small 4-week clinical study, people with mild atopic dermatitis, dry, and eczema-prone skin found using a daily emollient (soluble proteoglycan + hyaluronic acid + hydrolyzed collagen) significantly improved skin hydration, transepidermal water loss (TEWL), and itch.

Research also suggests that proteoglycans from sources like salmon nasal cartilage can "talk" to skin cells and encourage them to stay healthy by supporting the cells that maintain the skin's structure.

Other studies show proteoglycans may help skin recover from damage from things like UV exposure.