Curology DayPrime Rx Custom 3

Dupes for DayPrime Rx by Curology

Last updated on February 10, 2026

Welcome to our breakdown of the 14 best Curology DayPrime Rx Custom 3 dupes and alternatives.

Looking for dupes for a different product? You can use our Dupe Finder to search for them!

If you'd like to see the all of the Curology dupes that we've found, check out our best Curology dupes guide.

We use hundreds of science-backed factors to find you the best dupes.
Learn more about our dupe methodology

Our Roundup

Here's a quick roundup of our findings. Continue reading for the full breakdown!

Honest Beauty In The Clear Acne Serum
Most Similar Ingredients

Honest Beauty's In The Clear Acne Serum is the dupe with the most similar ingredients. Our matching methodology puts it at an 42% ingredient match!

Elixir Cosmeceuticals Niactil 4%
Most Liked

Of all of the dupes for this product, Elixir Cosmeceuticals's Niactil 4% is the most liked by our community. Our matching algorithm puts it at an 55% overall match!

Overview

What it is

Prescription with 21 ingredients that contains azelaic acid, BHA and ceramides

Cool Features

It is vegan, cruelty-free, and reef safe

Suited For

It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

It doesn't contain any harsh alcohols, common allergens, fragrances, oils, parabens or sulfates

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Dupe #3

Curology DayPrime Rx

62% match

with the ingredients and function of Honest Beauty In The Clear Acne Serum

83% Attribute Match
42% Ingredient Match

Dupe Explained

These products are both cruelty-free facial treatments that contain azelaic acid and BHA. They've got a total of 9 ingredients in common.

They both do not contain any harsh alcohols, common allergens, fragrances, oils, parabens or sulfates.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #4

Curology DayPrime Rx

61% match

with the ingredients and function of Isomers Skincare Laboratories 14% Azelaic Acid Booster Complex

74% Attribute Match
42% Ingredient Match

Dupe Explained

These products are both cruelty-free facial treatments that contain azelaic acid and BHA. They've got a total of 8 ingredients in common.

They both do not contain any harsh alcohols, common allergens, fragrances, oils or parabens. They both contain silicones.

They're both likely to be good for fighting acne, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #1

COLLISTAR Milano Salicylic Acid + Niacinamide Lotion

58% match

with the ingredients and function of Curology DayPrime Rx

70% Attribute Match
42% Ingredient Match

Dupe Explained

These products are both vegan and cruelty-free facial treatments that contain BHA. They've got a total of 6 ingredients in common.

They both do not contain any harsh alcohols, common allergens, fragrances, oils, parabens or sulfates.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #2

Genabelle Laser Vita-K Rescue Gel

57% match

with the ingredients and function of Curology DayPrime Rx

59% Attribute Match
44% Ingredient Match

Dupe Explained

These products are both facial treatments that contain ceramides. They've got a total of 7 ingredients in common.

They both do not contain any harsh alcohols, common allergens, oils, parabens or sulfates. They both contain silicones.

They're both likely to be good for anti aging, dry skin, brightening skin, sensitive skin, scar healing and dark spots.

Both products are also reef safe.

Price Comparison

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Don't miss the latest dupes
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Dupe #3

FOREO Espada BHA+PHA Blemish Solution

56% match

with the ingredients and function of Curology DayPrime Rx

68% Attribute Match
40% Ingredient Match

Dupe Explained

These products are both vegan and cruelty-free facial treatments that contain BHA. They've got a total of 7 ingredients in common.

They both do not contain any harsh alcohols, common allergens, parabens or sulfates.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #4

Elixir Cosmeceuticals Niactil 4%

55% match

with the ingredients and function of Curology DayPrime Rx

68% Attribute Match
36% Ingredient Match

Dupe Explained

These products are both cruelty-free facial treatments that contain BHA. They've got a total of 3 ingredients in common.

They both do not contain any harsh alcohols, common allergens, fragrances, oils, parabens or sulfates.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #5

Curology DayPrime Rx

54% match

with the ingredients and function of Séfralls 10% Azelaic Acid Acne Cream

64% Attribute Match
36% Ingredient Match

Dupe Explained

These products are both cruelty-free facial treatments that contain azelaic acid. They've got a total of 7 ingredients in common.

They both do not contain any harsh alcohols, parabens or sulfates. They both contain silicones.

They're both likely to be good for fighting acne, anti aging, dry skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #5

Barenbliss Pimple Warrior! Salicylic Acid Acne Drying Lotion

54% match

with the ingredients and function of Curology DayPrime Rx

68% Attribute Match
37% Ingredient Match

Dupe Explained

These products are both cruelty-free facial treatments that contain BHA. They've got a total of 6 ingredients in common.

They both do not contain any harsh alcohols, common allergens, fragrances, parabens or sulfates.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #6

Séfralls 14% Azelaic Acid Acne Cream

54% match

with the ingredients and function of Curology DayPrime Rx

64% Attribute Match
36% Ingredient Match

Dupe Explained

These products are both cruelty-free facial treatments that contain azelaic acid. They've got a total of 7 ingredients in common.

They both do not contain any harsh alcohols, parabens or sulfates. They both contain silicones.

They're both likely to be good for fighting acne, anti aging, dry skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #14

Curology DayPrime Rx

53% match

with the ingredients and function of John Jeff 20% Azelaic Acid Acne Treatment Gel

52% Attribute Match
39% Ingredient Match

Dupe Explained

These products are both facial treatments that contain azelaic acid. They've got a total of 7 ingredients in common.

They both do not contain any harsh alcohols, fragrances, oils, parabens or sulfates.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #7

Celavi Microdots Treatment Patch + Salicylic Acid

53% match

with the ingredients and function of Curology DayPrime Rx

56% Attribute Match
35% Ingredient Match

Dupe Explained

These products are both cruelty-free facial treatments that contain BHA. They've got a total of 7 ingredients in common.

They both do not contain any harsh alcohols, fragrances, parabens or sulfates.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #8

Millford AC On-Spot Cream

52% match

with the ingredients and function of Curology DayPrime Rx

55% Attribute Match
37% Ingredient Match

Dupe Explained

These products are both vegan and cruelty-free facial treatments that contain. They've got a total of 7 ingredients in common.

They both do not contain any harsh alcohols, common allergens, parabens or sulfates. They both contain silicones.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots.

Price Comparison

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #9

Carbon Theory Hypa Dart Microdart Spot Patches

51% match

with the ingredients and function of Curology DayPrime Rx

48% Attribute Match
36% Ingredient Match

Dupe Explained

These products are both vegan and cruelty-free facial treatments that contain BHA. They've got a total of 5 ingredients in common.

They both do not contain any harsh alcohols, common allergens, fragrances, oils, parabens or sulfates.

They're both likely to be good for fighting acne, dry skin, brightening skin, oily skin, reducing pores and scar healing.

Both products are also reef safe.

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

Dupe #10

Tia’m AC Fighting Spot RX Cream

49% match

with the ingredients and function of Curology DayPrime Rx

42% Attribute Match
37% Ingredient Match

Dupe Explained

These products are both cruelty-free facial treatments that contain. They've got a total of 7 ingredients in common.

They both do not contain any harsh alcohols, parabens or sulfates. They both contain silicones.

They're both likely to be good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing and dark spots.

Price Comparison

Learn more about this dupe

Looking for a full breakdown of the similarities and differences between these two products?

Check out our full comparison of these two products for all the details!

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