Methyl Estradiolpropanoate

Methyl Estradiolpropanoate, or MEP, is a man-made derivative of estradiol designed as a "soft estrogen" for skin. It’s commonly used in formulas for estrogen-deficient or mature skin.

It binds to estrogen receptors in the skin to help improve firmness, elasticity, and hydration.

Unlike traditional estrogen, MEP is active only in the skin. Once it's absorbed and reaches the bloodsteam, it is broken down into an inactive form. This feature allows it to mimic some of estrogen’s skin benefits without systemic hormone activity.

Clinical studies in postmenopausal women have shown that topical MEP improves dryness, dullness, laxity, and atrophy after 14-20 weeks of use with no measurable systemic estrogen effects.

Safety notes:
MEP is considered non-hormonal at the systemic level but mimics estrogen locally. It is not recommended for people with a history of estrogen-sensitive cancers unless cleared by a doctor. Please consult a medical professional about using this ingredient.