Cetyl-Pg Hydroxyethyl Palmitamide

This ingredient is a synthetic mimic for ceramide NS and is often called a "pseudo-ceramide". It was developed by Kao Corporation in Japan (the same corporation that owns Biore and Curel).

Ceramides play a big role in your stratum corneum, or the outermost layer of skin. Your stratum corneum is structured like a brick wall where skin cells are bricks and ceramides are a big part of the mortar holding everything together.

Aging, harsh cleansers, environmental damage, or skin conditions can cause ceramide levels to drop. This leads to moisture loss, irritation, and dryness.

How it works

This is where this ingredient steps in: it's structurally designed with the same key features as natural ceramides. Because of this, it can slot into the lipid layers of your stratum corneum and behave just like real ceramides.

Research on patients with atopic dermatitis, seborrheic dermatitis, and sensitive skin has shown that topical application of this ingredient enhances stratum corneum function.

Another four-week randomized study on lip care found formulas containing 0.5% or 2% of this ingredient improved lip dryness and roughness.

A study on hairdressers with occupational hand dermatitis found that a barrier cream containing this ingredient reduced dryness, scaling, cracking, redness, and itching.

And a more recent study confirmed that this ingredient is absorbed into the stratum corneum and reduces transepidermal water loss (TEWL), just like a real ceramide.

This ingredient is more stable, free from contaminants, and significantly cheaper to produce. This makes it more practical for everyday skincare formulations.