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Overview

What they are

These products are both cruelty-free and reef safe prescription. They have a total of 12 ingredients in common

Cool Features

They both contain retinoid and Vitamin E

Suited For

They're both likely to be good for fighting acne, anti aging, brightening skin, sensitive skin, reducing pores, scar healing and dark spots

Free From

They both do not contain any harsh alcohols, common allergens, oils, parabens, silicones or sulfates

What's Inside

They both contain fragrances

We independently verify ingredients, and our claims are backed by peer-reviewed research. Spot a product that needs an update? Let us know.

Ingredient Info

Click any item below to learn more and see relevant ingredients

At a glance

Click on any of the items below to learn more

Notable Ingredients

Benefits

Concerns

Notable Ingredients

Benefits

Concerns

Ingredients Side-by-side

found in both products
Custom Formula (Tretinoin 0.01% Azelaic acid 2% Niacinamide 4%)
Tretinoin
Retinoid  •  3 Benefits  •  2 Concerns

Tretinoin is the best retinoid due to its proven skin benefits. It only available with a prescription in many countries.

Azelaic Acid Buffering, Masking
5 Benefits

Azelaic acid is a naturally occurring acid derived from grains. This ingredient is effective in treating acne, rosacea, and other skin conditions.

Niacinamide Smoothing
Niacinamide  •  6 Benefits

Niacinamide has emerged as an all-star ingredient due to its many benefits.

Aloe Barbadensis Leaf Juice Skin Conditioning
2 Benefits

Aloe Barbadensis Leaf Juice comes from leaves of the aloe plant. Aloe Barbadensis Leaf Juice is best known for helping to soothe sunburns. It is also anti-inflammatory, moisturizing, antiseptic, and can help heal wounds.

C13-14 Isoparaffin Emollient, Solvent
2 Concerns

C13-14 Isoparaffin is created from petroleum-based mineral oils. It is an emollient and helps thicken a product.

Very Disliked Full details ->
Caprylic/Capric Triglyceride Masking, Skin Conditioning

Caprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Laureth-7 Emulsifying

Laureth-7 is created by the ethoxylation of lauryl alcohol using ethylene oxide. Lauryl alcohol is a fatty alcohol with hydrating properties.

Disliked Full details ->
Phenoxyethanol Preservative
Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Polyacrylamide

Polyacrylamide is a synthetic polymer. It is used to stabilize products and bind ingredients. When hydrated, Polyacrylamide forms a soft gel.

Disliked Full details ->
Tocopheryl Acetate Antioxidant, Skin Conditioning
0 / 0
Vitamin E  •  Antioxidant  •  Helps brighten skin

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

0 Com. / 0 Irr.
Triethylene Glycol Masking, Perfuming
Fragrance

Triethylene Glycol is a fragrance.

Unknown Full details ->
BHT Antioxidant, Masking
Antioxidant

BHT is a synthetic antioxidant. As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

Very Disliked Full details ->
Propylene Glycol Humectant, Skin Conditioning, Solvent
0 / 0
May worsen Eczema

Propylene Glycol is an odorless, colorless liquid. As a humectant, it helps skin retain moisture. It also aids in delivering active ingredients.

0 Com. / 0 Irr.
Very Disliked Full details ->
Custom Formula Tretinoin 0.01% Clindamycin 1% Azelaic Acid 4%
Tretinoin
Retinoid  •  3 Benefits  •  2 Concerns

Tretinoin is the best retinoid due to its proven skin benefits. It only available with a prescription in many countries.

Clindamycin Phosphate

Clindamycin Phosphate is a perscription ingredient used to treat acne.

Azelaic Acid Buffering, Masking
5 Benefits

Azelaic acid is a naturally occurring acid derived from grains. This ingredient is effective in treating acne, rosacea, and other skin conditions.

Aloe Barbadensis Leaf Juice Skin Conditioning
2 Benefits

Aloe Barbadensis Leaf Juice comes from leaves of the aloe plant. Aloe Barbadensis Leaf Juice is best known for helping to soothe sunburns. It is also anti-inflammatory, moisturizing, antiseptic, and can help heal wounds.

C13-14 Isoparaffin Emollient, Solvent
2 Concerns

C13-14 Isoparaffin is created from petroleum-based mineral oils. It is an emollient and helps thicken a product.

Very Disliked Full details ->
Caprylic/Capric Triglyceride Masking, Skin Conditioning

Caprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

Water Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

Laureth-7 Emulsifying

Laureth-7 is created by the ethoxylation of lauryl alcohol using ethylene oxide. Lauryl alcohol is a fatty alcohol with hydrating properties.

Disliked Full details ->
Phenoxyethanol Preservative
Preservative

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.

Very Disliked Full details ->
Polyacrylamide

Polyacrylamide is a synthetic polymer. It is used to stabilize products and bind ingredients. When hydrated, Polyacrylamide forms a soft gel.

Disliked Full details ->
Tocopheryl Acetate Antioxidant, Skin Conditioning
0 / 0
Vitamin E  •  Antioxidant  •  Helps brighten skin

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

0 Com. / 0 Irr.
Triethylene Glycol Masking, Perfuming
Fragrance

Triethylene Glycol is a fragrance.

Unknown Full details ->
BHT Antioxidant, Masking
Antioxidant

BHT is a synthetic antioxidant. As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

Very Disliked Full details ->

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Loved

Tretinoin is the best retinoid due to its proven skin benefits. It only available with a prescription in many countries.

All forms of OTC retinoids goes through a conversion line until it can become effective. The final step of conversion is retinoic acid; retinoic acid IS Tretinoin.

This is why tretinoin is so effective; it gets to work immediately on the skin.

Research on tretinoin has found it to be incredibly effective for reducing the signs of aging. It helps improve damage from the sun, even the skin tone, and smooth out wrinkles. It is also an effective acne treatment by reducing and balancing out sebum production in pores.

Tretinoin, like other forms of Vitamin A, increases the turnover cycle of skin cells. This helps the skin create newer and healthier skin cells faster.

It can cause irritation, redness, and dry skin because it is considered a "strong" ingredient. Those with sensitive skin should consult a professional about using tretinoin.

Using retinoids will increase sun-sensitivity in the first few weeks of use. Though studies show retinoids increase your skin's natural SPF with continuous use, it is best to always wear sunscreen and sun-protection.

Read about a form of retinoid you can purchase at the store, retinol.

Learn more about Tretinoin
Buffering, Masking
Loved

Azelaic acid is a naturally occurring acid derived from grains. This ingredient is effective in treating acne, rosacea, and other skin conditions.

It has been shown to reduce the growth of acne-causing bacteria and helps reduce inflammation. On top of that, it helps reduce the production of sebum and unclog pores.

Azelaic Acid also has antioxidant properties. Antioxidants protect our skin cells from free-radical damage.

One of the main benefits of azelaic acid is that it is gentle and well-tolerated by most people. It is also non-comedogenic, meaning that it will not clog pores.

Fun fact: The lab-created form of azelaic acid is typically used within cosmetic products for its shelf-stability.

Learn more about Azelaic Acid
Skin Conditioning
Liked

Aloe Barbadensis Leaf Juice comes from leaves of the aloe plant. Aloe Barbadensis Leaf Juice is best known for helping to soothe sunburns. It is also anti-inflammatory, moisturizing, antiseptic, and can help heal wounds.

Aloe is packed with good stuff including Vitamins A, C, and E. These vitamins are antioxidants, which help fight free-radicals and the damage they may cause. Free-radicals are molecules that may damage your skin cells, such as pollution.

Aloe Barbadensis Leaf Juice also contains sugars. These sugars come in the form of monosaccharides and polysaccharides, folic acid, and choline. These sugars are able to help bind moisture to skin.

It also contains minerals such as calcium, 12 anthraquinones, fatty acids, amino acids, and Vitamin B12.

Learn more about Aloe Barbadensis Leaf Juice
Emollient, Solvent
Very Disliked

C13-14 Isoparaffin is created from petroleum-based mineral oils. It is an emollient and helps thicken a product.

As an emollient, it helps keep the skin soft and smooth by creating a barrier on top. This barrier traps moisture in, keeping the skin hydrated.

C13-14 Isoparaffin may not be fungal-acne safe.

Learn more about C13-14 Isoparaffin
Masking, Skin Conditioning
Mixed

Caprylic/Capric Triglyceride is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

Within a product, Caprylic Triglyceride can thicken the product and make spreadability easier by dissolving clumping compounds. An added benefit of Caprylic Triglyceride is its antioxidant properties.

Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid. Caprylic Triglyceride has not been found to be toxic for human use in concentrations under 50%.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.

Learn more about Caprylic/Capric Triglyceride
Skin Conditioning, Solvent
Loved

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. Talk about multi-purpose! If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Emulsifying
Disliked

Laureth-7 is created by the ethoxylation of lauryl alcohol using ethylene oxide. Lauryl alcohol is a fatty alcohol with hydrating properties.

Laureth-7 is an emulsifier and cleansing ingredient. As an emulsifier, it is used to prevent ingredients from separating. It also helps cleanse the skin by gathering dirt, oil, and pollutants to be rinsed away.

Preservative
Very Disliked

Phenoxyethanol is a preservative that has germicide, antimicrobial, and aromatic properties. Studies show that phenoxyethanol can prevent germ and microbial growth. By itself, it has a scent that is similar to that of a rose.

It's often used in formulations along with Caprylyl Glycol to preserve the shelf life of products.

Disliked

Polyacrylamide is a synthetic polymer. It is used to stabilize products and bind ingredients. When hydrated, Polyacrylamide forms a soft gel.

Polyacrylamide is low-toxicity. If source properly, it is deemed safe to use in cosmetics.

It should be noted the precursor to Polyacrylamide is acrylamide. Acrylamide is a carcinogen. Most reputable sources of Polyacrylamide will screen for residual acrylamide to make sure the count is in a safe range. Acrylamide is not able to be absorbed through the skin.

We recommend speaking with a professional if you have concerns.

Learn more about Polyacrylamide
Antioxidant, Skin Conditioning
Liked

Tocopheryl Acetate is AKA Vitamin E. It is an antioxidant and protects your skin from free radicals. Free radicals damage the skin by breaking down collagen.

One study found using Tocopheryl Acetate with Vitamin C decreased the number of sunburned cells.

Tocopheryl Acetate is commonly found in both skincare and dietary supplements.

Learn more about Tocopheryl Acetate
Masking, Perfuming

Triethylene Glycol is a fragrance.

BHT
Antioxidant, Masking
Very Disliked

BHT is a synthetic antioxidant. As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

BHT also helps stabilize products and prevent them from degrading. Many products are sensitive to air and light. BHT prevents them from breaking down when exposed.

Ingredient Ratings

Here's what our community thinks of the ingredients in these two products.

Custom Formula (Tretinoin 0.01% Azelaic acid 2% Niacinamide 4%)
6
1
6
1
liked
mixed
disliked
not rated
Custom Formula Tretinoin 0.01% Clindamycin 1% Azelaic Acid 4%
6
1
5
1
liked
mixed
disliked
not rated

When to use

13 Routines
0% use in am
100% use in pm
77% use every day
43 Routines
7% use in am
93% use in pm
86% use every day
When to use See routines that use it ->

Reviews

Here's what our community thinks

Curology Custom Formula (Tretinoin 0.01% Azelaic acid 2% Niacinamide 4%) 14 ingredients

Custom Formula (Tretinoin 0.01% Azelaic acid 2% Niacinamide 4%) hasn't been rated yet.
Rate it now

Curology Custom Formula Tretinoin 0.01% Clindamycin 1% Azelaic Acid 4% 13 ingredients

5.0 /5
from 1 rating
sandraGarcia_117's avatar

sandraGarcia_117

8 months ago · Combination Skin
Review

I’ve tried this product and I loved it but is too expensive