MediCube One Day Zero Exosome Shot Zero Exosome Shot 25,000
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MediCube One Day Zero Exosome Shot

Type: Zero Exosome Shot 25,000
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Overview

What it is

Ampoule with 42 ingredients that contains BHA, ceramides, niacinamide, peptides and PHA

Cool Features

It is cruelty-free and reef safe

Suited For

It has ingredients that are good for fighting acne, anti aging, dry skin, brightening skin, sensitive skin, oily skin, reducing pores, scar healing, dark spots and better texture

Free From

It doesn't contain any harsh alcohols, common allergens, fragrances, oils, parabens, silicones or sulfates

Fun facts

MediCube is from South Korea.

We independently verify ingredients and our claims are backed by peer-reviewed research. Does this product need an update? Let us know.

What's inside

Ingredients List

19
12
11

Water

Skin Conditioning

Glycereth-26

Humectant
0 / 0 Helps hydrate Dry Skin Icon

Dipropylene Glycol

Humectant

Butylene Glycol

Humectant
1 / 0 Helps hydrate Dry Skin Icon

Caprylic/Capric Triglyceride

Masking
Helps hydrate Dry Skin Icon

Key Ingredients

Benefits

Concerns

Ingredients Explained

Skin Conditioning, Solvent

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Stay hydrated!

Learn more about Water
Humectant

Glycereth-26 is a synthetic ingredient and polyethylene glycol ether of Glycerin. Glycerin is already naturally found in your skin and helps keep your skin moisturized.

It is a humectant and helps add texture to products. It can make your product thicker.

As a humectant, it helps draw moisture from the air to your skin. This helps your skin stay hydrated.

Learn more about Glycereth-26
Humectant, Masking, Solvent

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the โ€˜goodโ€™ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Learn more about Dipropylene Glycol
Humectant, Masking, Skin Conditioning

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Learn more about Butylene Glycol
Masking, Skin Conditioning

This ingredient is an emollient, solvent, and texture enhancer. It is considered a skin-softener by helping the skin prevent moisture loss.

It helps thicken a product's formula and makes it easier to spread by dissolving clumping compounds.

Caprylic Triglyceride is made by combining glycerin with coconut oil, forming a clear liquid.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this.

Learn more about Caprylic/Capric Triglyceride
Smoothing

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Learn more about Niacinamide

Calcium Aluminum Borosilicate is made up of calcium, aluminum, and silicates. It is a glass-like material. In cosmetics, it comes in the form of flakes or microspheres.

Calcium aluminum borosilicate is a bulking agent, meaning it helps thicken a product.

This ingredient is created by slowly mixing several minerals, including kaolin clay.

Although โ€œaluminumโ€ in an ingredient name can raise red flags for some consumers, the form and usage context matter significantly. For typical topical applications, there is no substantial evidence of health risks - such as cancer, neurotoxicity, or systemic โ€œaluminum overload.โ€

Learn more about Calcium Aluminum Borosilicate
Skin Conditioning

We don't have a description for Hydrolyzed Sponge yet.

This long ingredient is a copolymer of sodium acrylate and sodium acryloyldimethyl taurate monomers.

It is used to help stabilize other ingredients and create a thicker gel-like texture.

Emulsifiers prevent oils and waters from separating.

Learn more about Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Skin Conditioning, Solvent

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.ย 

It is a:

  • Humectant, drawing moisture into the skin
  • Emollient, helping to soften skin
  • Solvent, dispersing and stabilizing formulas
  • Preservative booster, enhancing the antimicrobial activity of other preservativesย 
Emollient, Humectant, Skin Conditioning

Caprylyl Glycol is a humectant and emollient, meaning it attracts and preserves moisture.

It is a common ingredient in many products, especially those designed to hydrate skin. The primary benefits are retaining moisture, skin softening, and promoting a healthy skin barrier.

Though Caprylyl Glycol is an alcohol derived from fatty acids, it is not the kind that can dry out skin.

This ingredient is also used as a preservative to extend the life of products. It has slight antimicrobial properties.

Learn more about Caprylyl Glycol
Emollient, Skin Conditioning, Solvent

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

Due to its large size, Isohexadecane is not absorbed by the skin. Instead, it sits on top and acts as an emollient. Emollients help keep your skin soft and smooth by trapping moisture within.

Isohexadecane is often used in products designed to help oily skin. It is lightweight and non-greasy while helping to moisturize. When mixed with silicones, it gives a product a silky feel.

Learn more about Isohexadecane
Humectant, Skin Conditioning, Skin Protecting

Glycerin is already naturally found in your skin. It helps moisturize and protect your skin.

A study from 2016 found glycerin to be more effective as a humectant than AHAs and hyaluronic acid.

As a humectant, it helps the skin stay hydrated by pulling moisture to your skin. The low molecular weight of glycerin allows it to pull moisture into the deeper layers of your skin.

Hydrated skin improves your skin barrier; Your skin barrier helps protect against irritants and bacteria.

Glycerin has also been found to have antimicrobial and antiviral properties. Due to these properties, glycerin is often used in wound and burn treatments.

In cosmetics, glycerin is usually derived from plants such as soybean or palm. However, it can also be sourced from animals, such as tallow or animal fat.

This ingredient is organic, colorless, odorless, and non-toxic.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Learn more about Glycerin
Emulsifying

Polysorbate 80 is a surfactant and emulsifier. It is used to keep ingredients together, and prevent oils and waters from separating.

It is made from polyethoxylated sorbitan and oleic acid. This ingredient can be found in cosmetics, foods, and medicine. It is water-soluble.

Polysorbate 80 may not be fungal acne safe.

Learn more about Polysorbate 80
Emulsion Stabilising, Gel Forming

Carbomer is a polymer of acrylic acid. Its main role is to create a gel consistency.

A high amount of carbomer can cause pilling or balling up of products. Don't worry, most products contain 1% or less of carbomer.

Buffering, Masking

Tromethamine helps balance the pH and improve the texture of a product. It is synthetically created.

As an emulsifier, Tromethamine prevents oil and water ingredients from separating. This helps stabilize the product and elongate a product's shelf life. Tromethamine also makes a product thicker.

Tromethamine helps balance the pH level of a product. Normal pH level of skin is slightly acidic (~4.75-5.5). The acidity of our skin is maintained by our glands and skin biome. Being slightly acidic allows our skin to create an "acid mantle". This acid mantle is a thin barrier that protects our skin from bacteria and contaminants.

Oral Tromethanmine is an anti-inflammatory drug but plays the role of masking, adding fragrance, and/or balancing pH in skincare.

1,3-Propanediol, 2-amino-2-(hydroxymethyl)-

Learn more about Tromethamine
Skin Conditioning

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Learn more about Panthenol
Skin Conditioning

Ethylhexylglycerin (we can't pronounce this either) is commonly used as a preservative and skin softener. It is derived from glyceryl.

You might see Ethylhexylglycerin often paired with other preservatives such as phenoxyethanol. Ethylhexylglycerin has been found to increase the effectiveness of these other preservatives.

Skin Conditioning

Adenosine is in every living organism. It is one of four components in nucleic acids that helps store our DNA.

Adenosine has many benefits when used. These benefits include hydrating the skin, smoothing skin, and reducing wrinkles. Once applied, adenosine increases collagen production. It also helps with improving firmness and tissue repair.

Studies have found adenosine may also help with wound healing.

In skincare products, Adenosine is usually derived from yeast.

Learn more about Adenosine
Emulsifying

Sorbitan Oleate is created from compounds in oleic acid and sorbitol.

It is used to stabilize a product by preventing ingredients from separating. Emulsifiers help keep ingredients together, such as oils and water.

According to a manufacturer, the ingredient Sorbitan Monooleate shares an INCI name with this one.

Sorbitan Oleate may not be fungal acne safe. It can also worsen oily skin.

Learn more about Sorbitan Oleate
Emulsifying

Sorbitan Isostearate is an emulsifer and cleaning agent. It is created from isostearic acid and sorbitol.

As an emulsifier, Sorbitan Isostearate prevents oils and water from separating.

Due to its isostearic acid base, it may not be safe for Malassezia or fungal acne.

Learn more about Sorbitan Isostearate
Emulsifying

Polysorbate 60 is used to help stabilize products. It is a surfactant and emulsifier. These properties help keep ingredients together in a product. Surfactants help reduce surface tension between ingredients with different states, such as liquids and solids. Emulsifiers help prevent oils and waters from separating.

Polysorbate 60 is sorbitol-based and created from the ethoxylation of sorbitan. Ethoxylation is a chemical reaction used to add ethylene oxide. Sorbitan is a the dehydrated version of sorbitol, a sugar found in fruits.

In this case, the 60 comes from reacting 60 units of ethylene oxide with sorbitan.

Polysorbates are commonly used in medicine and foods.

Learn more about Polysorbate 60

Disodium EDTA plays a role in making products more stable by aiding other preservatives.

It is a chelating agent, meaning it neutralizes metal ions that may be found in a product.

Disodium EDTA is a salt of edetic acid and is found to be safe in cosmetic ingredients.

Learn more about Disodium EDTA

We don't have a description for Rosa Damascena Callus Extracellular Vesicles yet.

Skin Conditioning

We don't have a description for Kummerowia Striata Extract yet.

We don't have a description for Oenothera Biennis Flower Extract yet.

Skin Conditioning

This tree is also known as the David Elm. It contains the ingredient bakuchiol.

Other great compounds found in this ingredient include galactose, glucose, and phenolics. The sugar content gives it great skin hydrating properties. Phenolics are potent antioxidants commonly found in fruits and veggies.

A 2020 study found the phenolics of this root to have an anti-inflammatory effect.

Fun fact: This ingredient is used in traditional Asian medicine.

Learn more about Ulmus Davidiana Root Extract

We don't have a description for Pinus Palustris Leaf Extract yet.

We don't have a description for Pueraria Lobata Root Extract yet.

We don't have a description for Cinchona Pubescens Bark Extract yet.

Skin Conditioning

Gluconolactone is a PHA. PHAs are a great gentle alternative to traditional AHAs.

When applied, Gluconolactone has the same affect on skin as AHAs such as lactic acid. It helps dissolve the dead skin cells in the top layer of your skin. This improves texture and brightens the skin.

PHAs are more gentle than AHAs due to their larger structure. They do not penetrate as deeply as AHAs and take a longer time to dissolve dead cells. Studies show PHAs do not cause as much irritation.

Gluconolactone has some interesting properties:

In a 2004 study, Gluconolactone was found to prevent UV damage in mouse skin cells and has not been found to increase sun sensitivity. However, we still recommend wearing SPF daily.

This ingredient is is an created by reacting gluconic acid with an alcohol.

Learn more about Gluconolactone
Antimicrobial

Betaine Salicylate is considered a salicylic acid alternative.

Limited studies exist proving this ingredient to be a complete alternative to salicylic acid. Based on existing research, this ingredient does not penetrate as deeply and is not shown to be as effective.

However, this makes it a great choice for those with sensitive skin or need gentle BHA action.

This ingredient is created using betaine and salicylic acid.

This ingredient is oil-soluble and is most effective at a pH range of 3.8-4.2.

Learn more about Betaine Salicylate
Buffering, Masking

Citric Acid is an AHA derived from citrus fruits (think oranges, lemons, and limes!).

As an AHA, Citric Acid removes the top layer of skin cells from the newer layer of skin underneath. This helps skin to remove dark spots and even out skin tone.

If you spot Citric Acid near the end of an ingredient list, it's likely there as a pH adjuster rather than an active ingredient.

Read more about some other popular AHA's here:

Learn more about Citric Acid
Emollient, Skin Conditioning

We don't have a description for Milk Exosomes yet.

We don't have a description for Leptospermum Scoparium Leaf Extract yet.

Emulsifying, Skin Conditioning

Hydrogenated Lecithin is created from the hydrogenation of lecithin (a group of phospholipids). Hydrogenation is a chemical reaction between hydrogen and another element.

This ingredient is an emollient and emulsifier. As an emollient, it helps soften skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Skin Conditioning

Polyglyceryl-10 Laurate is an ester of lauric acid and Polyglycerin-10.

Polyglyceryl-10 Laurate is a cleansing agent and emulsifier. It helps gather dirt, oil, and other pollutants to be rinsed away. As an emulsifier, it helps prevent ingredients from separating, such as oil and water.

Polyglyceryl-10 Laurate may not be fungal acne safe.

Learn more about Polyglyceryl-10 Laurate
Skin Conditioning

Ceramide NP is a type of ceramide.

Ceramides are intercellular lipids naturally found in our skin that bonds dead skin cells together to create a barrier. They are known for their ability to hold water and thus are a great ingredient for dry skin.

Ceramides are an important building block for our skin barrier. A stronger barrier helps the skin look more firm and hydrated. By bolstering the skin ceramides act as a barrier against irritating ingredients. This can help with inflammation as well.

If you would like to eat ceramides, sweet potatoes contain a small amount.

Read more about other common types of ceramides here:
Ceramide AP
Ceramide EOP

Learn more about Ceramide NP

Acetyl Tetrapeptide-5 is a peptide that goes by another name, eyeseryl, due to claims that it can help reduce eye puffiness.

The manufacturer claims this ingredient reduces eye puffiness by:

An in-vivo study from the manufacturer found 95% of volunteers saw eye bag improvement by the end of the study.

Eye puffiness is caused by two major factors: fluid retention and fat.

Those with fluid retention may see improvement from using this ingredient. However, those with eye fat will need surgical intervention in order to get rid of puffiness.

Learn more about Acetyl Tetrapeptide-5
Skin Conditioning

You might know this ingredients as Matrixyl, a famous peptide.

Peptides are building blocks for protein. Palmitoyl Pentapeptide-4 consists of five amino acids. These amino acids include: 2 lysines, 2 threonines, and serine

This ingredients tells our body to create more collagen. Collagen is a protein that makes connective tissue. Boosting collagen production leads to a healthier skin barrier. Having a healthy skin barrier means having firm and hydrated skin.

Thus, Matrixyl may help improve the look of wrinkles.

Read more about other common types of peptides here:

Learn more about Palmitoyl Pentapeptide-4
Skin Conditioning

This synthetic peptide is created from lysine, valine, and palmitic acid.

According to the manufacturer, in-vitro studies show tissue growth and collagen synthesis. Another in-vivo study found 60 volunteers saw a significant reduction in wrinkles after 84 days.

Due to its palmitic acid base, this peptide may not be fungal-acne safe.

Learn more about Palmitoyl Tripeptide-5

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Light 75% Absorbs Well 75% Expensive 50%
4 reviews

Where it's from

MediCube is a Korean brand

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Verified by SkinSort

We're dedicated to providing you with the most up-to-date and science-backed ingredient info out there.

The data we've presented on this page has been verified by a member of the SkinSort Team.

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ยท Published August 5, 2025 Added by matthewalexander